A direct interview family study of obsessive–compulsive disorder. I
Background. This and the companion paper present two sequential family studies of obsessive–compulsive disorder (OCD) conducted by the same research group, but with different sampling and best-estimate procedures. In addition to providing further data on familial transmission of OCD, we used compari...
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Veröffentlicht in: | Psychological medicine 2005-11, Vol.35 (11), p.1611-1621 |
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description | Background. This and the companion paper present two sequential family studies of obsessive–compulsive disorder (OCD) conducted by the same research group, but with different sampling and best-estimate procedures. In addition to providing further data on familial transmission of OCD, we used comparison of disparate findings (moderate, specific familial aggregation in this first study versus a stronger effect for other anxiety disorders than for OCD alone in the second) to examine possible effects of proband characteristics and informant data on outcome. Method. In this initial study we interviewed 179 first-degree relatives of 72 OCD probands and 112 relatives of 32 never mentally ill (NMI) controls. Informant data were obtained on an additional 126 relatives (total ‘combined’ samples of 263 and 154 respectively). Analyses used best-estimate diagnoses made by consensus of two ‘blinded’ senior clinicians who reviewed all diagnostic materials including proband informant data about relatives. Results. Significantly higher risk for OCD but not other anxiety disorders was found in relatives of OCD probands compared to relatives of controls in both the directly interviewed and combined samples. There was no relationship between proband age at onset of OCD and strength of familial aggregation. Conclusions. These data indicate moderate familial aggregation of OCD, but do not support increased transmission by early onset probands, or a familial relationship between OCD and other anxiety disorders with the possible exception of generalized anxiety disorder. |
doi_str_mv | 10.1017/S0033291705005441 |
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I</title><source>MEDLINE</source><source>Applied Social Sciences Index & Abstracts (ASSIA)</source><source>Cambridge Journals Online</source><creator>FYER, ABBY J. ; LIPSITZ, JOSHUA D. ; MANNUZZA, SALVATORE ; ARONOWITZ, BONNIE ; CHAPMAN, TIMOTHY F.</creator><creatorcontrib>FYER, ABBY J. ; LIPSITZ, JOSHUA D. ; MANNUZZA, SALVATORE ; ARONOWITZ, BONNIE ; CHAPMAN, TIMOTHY F.</creatorcontrib><description>Background. This and the companion paper present two sequential family studies of obsessive–compulsive disorder (OCD) conducted by the same research group, but with different sampling and best-estimate procedures. In addition to providing further data on familial transmission of OCD, we used comparison of disparate findings (moderate, specific familial aggregation in this first study versus a stronger effect for other anxiety disorders than for OCD alone in the second) to examine possible effects of proband characteristics and informant data on outcome. Method. In this initial study we interviewed 179 first-degree relatives of 72 OCD probands and 112 relatives of 32 never mentally ill (NMI) controls. Informant data were obtained on an additional 126 relatives (total ‘combined’ samples of 263 and 154 respectively). Analyses used best-estimate diagnoses made by consensus of two ‘blinded’ senior clinicians who reviewed all diagnostic materials including proband informant data about relatives. Results. Significantly higher risk for OCD but not other anxiety disorders was found in relatives of OCD probands compared to relatives of controls in both the directly interviewed and combined samples. There was no relationship between proband age at onset of OCD and strength of familial aggregation. Conclusions. These data indicate moderate familial aggregation of OCD, but do not support increased transmission by early onset probands, or a familial relationship between OCD and other anxiety disorders with the possible exception of generalized anxiety disorder.</description><identifier>ISSN: 0033-2917</identifier><identifier>EISSN: 1469-8978</identifier><identifier>DOI: 10.1017/S0033291705005441</identifier><identifier>PMID: 16219119</identifier><identifier>CODEN: PSMDCO</identifier><language>eng</language><publisher>Cambridge, UK: Cambridge University Press</publisher><subject>Adult ; Adult and adolescent clinical studies ; Age of Onset ; Anxiety ; Anxiety disorders ; Anxiety disorders. Neuroses ; Biological and medical sciences ; Families & family life ; Family ; Family Health ; Family studies ; Female ; Humans ; Male ; Medical sciences ; Mental disorders ; Neuroses ; Obsessive compulsive disorder ; Obsessive-Compulsive Disorder - epidemiology ; Obsessive-compulsive disorders ; Obsessive-Compulsive neuroses ; Original Article ; Psychology. Psychoanalysis. Psychiatry ; Psychopathology. Psychiatry ; United States - epidemiology</subject><ispartof>Psychological medicine, 2005-11, Vol.35 (11), p.1611-1621</ispartof><rights>2005 Cambridge University Press</rights><rights>2006 INIST-CNRS</rights><rights>Copyright Cambridge University Press, Publishing Division Nov 2005</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c469t-cd44b9b9501af6bf2c5a81117ce1e713a99f888fb5abe046037badc1f3dbcab03</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.cambridge.org/core/product/identifier/S0033291705005441/type/journal_article$$EHTML$$P50$$Gcambridge$$H</linktohtml><link.rule.ids>164,314,780,784,12846,27924,27925,30999,31000,55628</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=17273886$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/16219119$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>FYER, ABBY J.</creatorcontrib><creatorcontrib>LIPSITZ, JOSHUA D.</creatorcontrib><creatorcontrib>MANNUZZA, SALVATORE</creatorcontrib><creatorcontrib>ARONOWITZ, BONNIE</creatorcontrib><creatorcontrib>CHAPMAN, TIMOTHY F.</creatorcontrib><title>A direct interview family study of obsessive–compulsive disorder. I</title><title>Psychological medicine</title><addtitle>Psychol. Med</addtitle><description>Background. This and the companion paper present two sequential family studies of obsessive–compulsive disorder (OCD) conducted by the same research group, but with different sampling and best-estimate procedures. In addition to providing further data on familial transmission of OCD, we used comparison of disparate findings (moderate, specific familial aggregation in this first study versus a stronger effect for other anxiety disorders than for OCD alone in the second) to examine possible effects of proband characteristics and informant data on outcome. Method. In this initial study we interviewed 179 first-degree relatives of 72 OCD probands and 112 relatives of 32 never mentally ill (NMI) controls. Informant data were obtained on an additional 126 relatives (total ‘combined’ samples of 263 and 154 respectively). Analyses used best-estimate diagnoses made by consensus of two ‘blinded’ senior clinicians who reviewed all diagnostic materials including proband informant data about relatives. Results. Significantly higher risk for OCD but not other anxiety disorders was found in relatives of OCD probands compared to relatives of controls in both the directly interviewed and combined samples. There was no relationship between proband age at onset of OCD and strength of familial aggregation. Conclusions. These data indicate moderate familial aggregation of OCD, but do not support increased transmission by early onset probands, or a familial relationship between OCD and other anxiety disorders with the possible exception of generalized anxiety disorder.</description><subject>Adult</subject><subject>Adult and adolescent clinical studies</subject><subject>Age of Onset</subject><subject>Anxiety</subject><subject>Anxiety disorders</subject><subject>Anxiety disorders. Neuroses</subject><subject>Biological and medical sciences</subject><subject>Families & family life</subject><subject>Family</subject><subject>Family Health</subject><subject>Family studies</subject><subject>Female</subject><subject>Humans</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Mental disorders</subject><subject>Neuroses</subject><subject>Obsessive compulsive disorder</subject><subject>Obsessive-Compulsive Disorder - epidemiology</subject><subject>Obsessive-compulsive disorders</subject><subject>Obsessive-Compulsive neuroses</subject><subject>Original Article</subject><subject>Psychology. Psychoanalysis. Psychiatry</subject><subject>Psychopathology. 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I</title><author>FYER, ABBY J. ; LIPSITZ, JOSHUA D. ; MANNUZZA, SALVATORE ; ARONOWITZ, BONNIE ; CHAPMAN, TIMOTHY F.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c469t-cd44b9b9501af6bf2c5a81117ce1e713a99f888fb5abe046037badc1f3dbcab03</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2005</creationdate><topic>Adult</topic><topic>Adult and adolescent clinical studies</topic><topic>Age of Onset</topic><topic>Anxiety</topic><topic>Anxiety disorders</topic><topic>Anxiety disorders. Neuroses</topic><topic>Biological and medical sciences</topic><topic>Families & family life</topic><topic>Family</topic><topic>Family Health</topic><topic>Family studies</topic><topic>Female</topic><topic>Humans</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Mental disorders</topic><topic>Neuroses</topic><topic>Obsessive compulsive disorder</topic><topic>Obsessive-Compulsive Disorder - epidemiology</topic><topic>Obsessive-compulsive disorders</topic><topic>Obsessive-Compulsive neuroses</topic><topic>Original Article</topic><topic>Psychology. Psychoanalysis. Psychiatry</topic><topic>Psychopathology. Psychiatry</topic><topic>United States - epidemiology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>FYER, ABBY J.</creatorcontrib><creatorcontrib>LIPSITZ, JOSHUA D.</creatorcontrib><creatorcontrib>MANNUZZA, SALVATORE</creatorcontrib><creatorcontrib>ARONOWITZ, BONNIE</creatorcontrib><creatorcontrib>CHAPMAN, TIMOTHY F.</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Social Sciences Premium Collection【Remote access available】</collection><collection>ProQuest Central (Corporate)</collection><collection>Applied Social Sciences Index & Abstracts (ASSIA)</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Chemoreception Abstracts</collection><collection>ProQuest Nursing and Allied Health Journals</collection><collection>Neurosciences Abstracts</collection><collection>ProQuest Health and Medical</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Psychology Database (Alumni)</collection><collection>Technology Research Database</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Research Library (Alumni Edition)</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest Central</collection><collection>Social Science Premium Collection</collection><collection>ProQuest Central Essentials</collection><collection>AUTh Library subscriptions: ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>Sociology Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>PML(ProQuest Medical Library)</collection><collection>ProQuest Psychology Journals</collection><collection>ProQuest Research Library</collection><collection>Sociology Database (ProQuest)</collection><collection>Research Library (Corporate)</collection><collection>Nursing & Allied Health Premium</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest One Psychology</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><jtitle>Psychological medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>FYER, ABBY J.</au><au>LIPSITZ, JOSHUA D.</au><au>MANNUZZA, SALVATORE</au><au>ARONOWITZ, BONNIE</au><au>CHAPMAN, TIMOTHY F.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>A direct interview family study of obsessive–compulsive disorder. I</atitle><jtitle>Psychological medicine</jtitle><addtitle>Psychol. Med</addtitle><date>2005-11-01</date><risdate>2005</risdate><volume>35</volume><issue>11</issue><spage>1611</spage><epage>1621</epage><pages>1611-1621</pages><issn>0033-2917</issn><eissn>1469-8978</eissn><coden>PSMDCO</coden><abstract>Background. This and the companion paper present two sequential family studies of obsessive–compulsive disorder (OCD) conducted by the same research group, but with different sampling and best-estimate procedures. In addition to providing further data on familial transmission of OCD, we used comparison of disparate findings (moderate, specific familial aggregation in this first study versus a stronger effect for other anxiety disorders than for OCD alone in the second) to examine possible effects of proband characteristics and informant data on outcome. Method. In this initial study we interviewed 179 first-degree relatives of 72 OCD probands and 112 relatives of 32 never mentally ill (NMI) controls. Informant data were obtained on an additional 126 relatives (total ‘combined’ samples of 263 and 154 respectively). Analyses used best-estimate diagnoses made by consensus of two ‘blinded’ senior clinicians who reviewed all diagnostic materials including proband informant data about relatives. Results. Significantly higher risk for OCD but not other anxiety disorders was found in relatives of OCD probands compared to relatives of controls in both the directly interviewed and combined samples. There was no relationship between proband age at onset of OCD and strength of familial aggregation. Conclusions. These data indicate moderate familial aggregation of OCD, but do not support increased transmission by early onset probands, or a familial relationship between OCD and other anxiety disorders with the possible exception of generalized anxiety disorder.</abstract><cop>Cambridge, UK</cop><pub>Cambridge University Press</pub><pmid>16219119</pmid><doi>10.1017/S0033291705005441</doi><tpages>11</tpages></addata></record> |
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subjects | Adult Adult and adolescent clinical studies Age of Onset Anxiety Anxiety disorders Anxiety disorders. Neuroses Biological and medical sciences Families & family life Family Family Health Family studies Female Humans Male Medical sciences Mental disorders Neuroses Obsessive compulsive disorder Obsessive-Compulsive Disorder - epidemiology Obsessive-compulsive disorders Obsessive-Compulsive neuroses Original Article Psychology. Psychoanalysis. Psychiatry Psychopathology. Psychiatry United States - epidemiology |
title | A direct interview family study of obsessive–compulsive disorder. I |
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