Autologous Serum for the Treatment of Corneal Epithelial Abrasions in Diabetic Patients Undergoing Vitrectomy
To compare the effect of autologous serum versus hyaluronic acid for the treatment of epithelial corneal lesions in patients such as diabetics with reduced wound healing. Prospective, randomized, masked clinical trial. Diabetic patients undergoing pars plana vitrectomy mostly combined with cataract...
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| Veröffentlicht in: | American journal of ophthalmology 2006-08, Vol.142 (2), p.207-211 |
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| creator | Schulze, Stephan D. Sekundo, Walter Kroll, Peter |
| description | To compare the effect of autologous serum versus hyaluronic acid for the treatment of epithelial corneal lesions in patients such as diabetics with reduced wound healing.
Prospective, randomized, masked clinical trial.
Diabetic patients undergoing pars plana vitrectomy mostly combined with cataract extraction and intraocular lens (IOL) implantation who received corneal abrasion for better intraoperative visualization were included in this study. A standardized 8-mm diameter corneal abrasion was performed. Patients were randomized into one group treated with hourly application of autologous serum and another treated with hyaluronic acid drops (Vislube). Besides the time necessary for closure of the corneal epithelium other parameters such as patients’ age, gender, duration of surgery, history of diabetes, and current HbA1C were evaluated.
A total of 23 patients were enrolled (15 men, eight women); the autologous serum group consisted of 13 patients, the hyaluronic acid (Vislube) group consisted of 10 patients. Patients’ mean age was 64.8 years; mean duration of diabetes was 19.4 years. On average, the operation lasted 145 minutes. Mean epithelialization time was 7.1 days in the hyaluronic acid group. In the autologous serum group, epithelium healed after a mean of 4.3 days. Mann-Whitney
U test for statistical analysis showed a significant difference of epithelial closure time between both groups (
P < .05); therefore, the study was stopped after treatment of 23 patients.
It appears that autologous serum leads to a much faster closure of corneal epithelial wounds after abrasion compared with artificial tears. |
| doi_str_mv | 10.1016/j.ajo.2006.04.017 |
| format | Article |
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Prospective, randomized, masked clinical trial.
Diabetic patients undergoing pars plana vitrectomy mostly combined with cataract extraction and intraocular lens (IOL) implantation who received corneal abrasion for better intraoperative visualization were included in this study. A standardized 8-mm diameter corneal abrasion was performed. Patients were randomized into one group treated with hourly application of autologous serum and another treated with hyaluronic acid drops (Vislube). Besides the time necessary for closure of the corneal epithelium other parameters such as patients’ age, gender, duration of surgery, history of diabetes, and current HbA1C were evaluated.
A total of 23 patients were enrolled (15 men, eight women); the autologous serum group consisted of 13 patients, the hyaluronic acid (Vislube) group consisted of 10 patients. Patients’ mean age was 64.8 years; mean duration of diabetes was 19.4 years. On average, the operation lasted 145 minutes. Mean epithelialization time was 7.1 days in the hyaluronic acid group. In the autologous serum group, epithelium healed after a mean of 4.3 days. Mann-Whitney
U test for statistical analysis showed a significant difference of epithelial closure time between both groups (
P < .05); therefore, the study was stopped after treatment of 23 patients.
It appears that autologous serum leads to a much faster closure of corneal epithelial wounds after abrasion compared with artificial tears.</description><identifier>ISSN: 0002-9394</identifier><identifier>EISSN: 1879-1891</identifier><identifier>DOI: 10.1016/j.ajo.2006.04.017</identifier><identifier>PMID: 16876497</identifier><identifier>CODEN: AJOPAA</identifier><language>eng</language><publisher>New York, NY: Elsevier Inc</publisher><subject>Biological and medical sciences ; Cataract Extraction ; Defects ; Diabetes ; Diabetes. Impaired glucose tolerance ; Diabetic retinopathy ; Diabetic Retinopathy - surgery ; Double-Blind Method ; Endocrine pancreas. Apud cells (diseases) ; Endocrinopathies ; Epithelium, Corneal - injuries ; Etiopathogenesis. Screening. Investigations. Target tissue resistance ; Eye Injuries - etiology ; Eye Injuries - therapy ; Female ; Glycated Hemoglobin A - analysis ; Humans ; Hyaluronic Acid - administration & dosage ; Hypotheses ; Lens Implantation, Intraocular ; Male ; Medical sciences ; Middle Aged ; Miscellaneous ; Ophthalmic Solutions - administration & dosage ; Ophthalmology ; Prospective Studies ; Serum ; Standard deviation ; Surgery ; Vitrectomy - adverse effects ; Vitreoretinopathy, Proliferative - surgery ; Wound healing ; Wound Healing - drug effects</subject><ispartof>American journal of ophthalmology, 2006-08, Vol.142 (2), p.207-211</ispartof><rights>2006 Elsevier Inc.</rights><rights>2006 INIST-CNRS</rights><rights>Copyright Elsevier Limited Aug 2006</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c475t-ba7eeb0208f8eef878c5574120378b9e255fc5e3492833de4517530bede873283</citedby><cites>FETCH-LOGICAL-c475t-ba7eeb0208f8eef878c5574120378b9e255fc5e3492833de4517530bede873283</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0002939406004806$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=18020840$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/16876497$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Schulze, Stephan D.</creatorcontrib><creatorcontrib>Sekundo, Walter</creatorcontrib><creatorcontrib>Kroll, Peter</creatorcontrib><title>Autologous Serum for the Treatment of Corneal Epithelial Abrasions in Diabetic Patients Undergoing Vitrectomy</title><title>American journal of ophthalmology</title><addtitle>Am J Ophthalmol</addtitle><description>To compare the effect of autologous serum versus hyaluronic acid for the treatment of epithelial corneal lesions in patients such as diabetics with reduced wound healing.
Prospective, randomized, masked clinical trial.
Diabetic patients undergoing pars plana vitrectomy mostly combined with cataract extraction and intraocular lens (IOL) implantation who received corneal abrasion for better intraoperative visualization were included in this study. A standardized 8-mm diameter corneal abrasion was performed. Patients were randomized into one group treated with hourly application of autologous serum and another treated with hyaluronic acid drops (Vislube). Besides the time necessary for closure of the corneal epithelium other parameters such as patients’ age, gender, duration of surgery, history of diabetes, and current HbA1C were evaluated.
A total of 23 patients were enrolled (15 men, eight women); the autologous serum group consisted of 13 patients, the hyaluronic acid (Vislube) group consisted of 10 patients. Patients’ mean age was 64.8 years; mean duration of diabetes was 19.4 years. On average, the operation lasted 145 minutes. Mean epithelialization time was 7.1 days in the hyaluronic acid group. In the autologous serum group, epithelium healed after a mean of 4.3 days. Mann-Whitney
U test for statistical analysis showed a significant difference of epithelial closure time between both groups (
P < .05); therefore, the study was stopped after treatment of 23 patients.
It appears that autologous serum leads to a much faster closure of corneal epithelial wounds after abrasion compared with artificial tears.</description><subject>Biological and medical sciences</subject><subject>Cataract Extraction</subject><subject>Defects</subject><subject>Diabetes</subject><subject>Diabetes. Impaired glucose tolerance</subject><subject>Diabetic retinopathy</subject><subject>Diabetic Retinopathy - surgery</subject><subject>Double-Blind Method</subject><subject>Endocrine pancreas. Apud cells (diseases)</subject><subject>Endocrinopathies</subject><subject>Epithelium, Corneal - injuries</subject><subject>Etiopathogenesis. Screening. Investigations. Target tissue resistance</subject><subject>Eye Injuries - etiology</subject><subject>Eye Injuries - therapy</subject><subject>Female</subject><subject>Glycated Hemoglobin A - analysis</subject><subject>Humans</subject><subject>Hyaluronic Acid - administration & dosage</subject><subject>Hypotheses</subject><subject>Lens Implantation, Intraocular</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Miscellaneous</subject><subject>Ophthalmic Solutions - administration & dosage</subject><subject>Ophthalmology</subject><subject>Prospective Studies</subject><subject>Serum</subject><subject>Standard deviation</subject><subject>Surgery</subject><subject>Vitrectomy - adverse effects</subject><subject>Vitreoretinopathy, Proliferative - surgery</subject><subject>Wound healing</subject><subject>Wound Healing - drug effects</subject><issn>0002-9394</issn><issn>1879-1891</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2006</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kV-L1DAUxYMo7rj6AXyRgKxvrUmbf8WnYVxdYUHBXV9Dmt6OKW0yJqmw394MM7Dgwz4lufmdy73nIPSWkpoSKj5OtZlC3RAiasJqQuUztKFKdhVVHX2ONoSQpurajl2gVylN5Skkky_RBRVKCtbJDVq2aw5z2Ic14Z8Q1wWPIeL8G_BdBJMX8BmHEe9C9GBmfH1w5W925brto0ku-ISdx5-d6SE7i3-Y7Iom4Xs_QNwH5_f4l8sRbA7Lw2v0YjRzgjfn8xLdf7m-291Ut9-_ftttbyvLJM9VbyRATxqiRgUwKqks55LRhrRS9R00nI-WQ8u6RrXtAIxTyVvSwwBKtqV2iT6c-h5i-LNCynpxycI8Gw9lUy2UUB0jTQHf_wdOYY2-zKapYKwwQvFC0RNlY0gpwqgP0S0mPmhK9DEJPemShD4moQnTJYmieXfuvPYLDI-Ks_UFuDoDJlkzj9F469Ijp477M1K4TycOimF_HUSdbLHYwuCOruohuCfG-AeRWaYK</recordid><startdate>20060801</startdate><enddate>20060801</enddate><creator>Schulze, Stephan D.</creator><creator>Sekundo, Walter</creator><creator>Kroll, Peter</creator><general>Elsevier Inc</general><general>Elsevier</general><general>Elsevier Limited</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>K9.</scope><scope>NAPCQ</scope><scope>7X8</scope></search><sort><creationdate>20060801</creationdate><title>Autologous Serum for the Treatment of Corneal Epithelial Abrasions in Diabetic Patients Undergoing Vitrectomy</title><author>Schulze, Stephan D. ; Sekundo, Walter ; Kroll, Peter</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c475t-ba7eeb0208f8eef878c5574120378b9e255fc5e3492833de4517530bede873283</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2006</creationdate><topic>Biological and medical sciences</topic><topic>Cataract Extraction</topic><topic>Defects</topic><topic>Diabetes</topic><topic>Diabetes. Impaired glucose tolerance</topic><topic>Diabetic retinopathy</topic><topic>Diabetic Retinopathy - surgery</topic><topic>Double-Blind Method</topic><topic>Endocrine pancreas. Apud cells (diseases)</topic><topic>Endocrinopathies</topic><topic>Epithelium, Corneal - injuries</topic><topic>Etiopathogenesis. Screening. Investigations. Target tissue resistance</topic><topic>Eye Injuries - etiology</topic><topic>Eye Injuries - therapy</topic><topic>Female</topic><topic>Glycated Hemoglobin A - analysis</topic><topic>Humans</topic><topic>Hyaluronic Acid - administration & dosage</topic><topic>Hypotheses</topic><topic>Lens Implantation, Intraocular</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Miscellaneous</topic><topic>Ophthalmic Solutions - administration & dosage</topic><topic>Ophthalmology</topic><topic>Prospective Studies</topic><topic>Serum</topic><topic>Standard deviation</topic><topic>Surgery</topic><topic>Vitrectomy - adverse effects</topic><topic>Vitreoretinopathy, Proliferative - surgery</topic><topic>Wound healing</topic><topic>Wound Healing - drug effects</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Schulze, Stephan D.</creatorcontrib><creatorcontrib>Sekundo, Walter</creatorcontrib><creatorcontrib>Kroll, Peter</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Premium</collection><collection>MEDLINE - Academic</collection><jtitle>American journal of ophthalmology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Schulze, Stephan D.</au><au>Sekundo, Walter</au><au>Kroll, Peter</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Autologous Serum for the Treatment of Corneal Epithelial Abrasions in Diabetic Patients Undergoing Vitrectomy</atitle><jtitle>American journal of ophthalmology</jtitle><addtitle>Am J Ophthalmol</addtitle><date>2006-08-01</date><risdate>2006</risdate><volume>142</volume><issue>2</issue><spage>207</spage><epage>211</epage><pages>207-211</pages><issn>0002-9394</issn><eissn>1879-1891</eissn><coden>AJOPAA</coden><abstract>To compare the effect of autologous serum versus hyaluronic acid for the treatment of epithelial corneal lesions in patients such as diabetics with reduced wound healing.
Prospective, randomized, masked clinical trial.
Diabetic patients undergoing pars plana vitrectomy mostly combined with cataract extraction and intraocular lens (IOL) implantation who received corneal abrasion for better intraoperative visualization were included in this study. A standardized 8-mm diameter corneal abrasion was performed. Patients were randomized into one group treated with hourly application of autologous serum and another treated with hyaluronic acid drops (Vislube). Besides the time necessary for closure of the corneal epithelium other parameters such as patients’ age, gender, duration of surgery, history of diabetes, and current HbA1C were evaluated.
A total of 23 patients were enrolled (15 men, eight women); the autologous serum group consisted of 13 patients, the hyaluronic acid (Vislube) group consisted of 10 patients. Patients’ mean age was 64.8 years; mean duration of diabetes was 19.4 years. On average, the operation lasted 145 minutes. Mean epithelialization time was 7.1 days in the hyaluronic acid group. In the autologous serum group, epithelium healed after a mean of 4.3 days. Mann-Whitney
U test for statistical analysis showed a significant difference of epithelial closure time between both groups (
P < .05); therefore, the study was stopped after treatment of 23 patients.
It appears that autologous serum leads to a much faster closure of corneal epithelial wounds after abrasion compared with artificial tears.</abstract><cop>New York, NY</cop><pub>Elsevier Inc</pub><pmid>16876497</pmid><doi>10.1016/j.ajo.2006.04.017</doi><tpages>5</tpages></addata></record> |
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| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Biological and medical sciences Cataract Extraction Defects Diabetes Diabetes. Impaired glucose tolerance Diabetic retinopathy Diabetic Retinopathy - surgery Double-Blind Method Endocrine pancreas. Apud cells (diseases) Endocrinopathies Epithelium, Corneal - injuries Etiopathogenesis. Screening. Investigations. Target tissue resistance Eye Injuries - etiology Eye Injuries - therapy Female Glycated Hemoglobin A - analysis Humans Hyaluronic Acid - administration & dosage Hypotheses Lens Implantation, Intraocular Male Medical sciences Middle Aged Miscellaneous Ophthalmic Solutions - administration & dosage Ophthalmology Prospective Studies Serum Standard deviation Surgery Vitrectomy - adverse effects Vitreoretinopathy, Proliferative - surgery Wound healing Wound Healing - drug effects |
| title | Autologous Serum for the Treatment of Corneal Epithelial Abrasions in Diabetic Patients Undergoing Vitrectomy |
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