Compensatory Responses to Pyruvate Carboxylase Suppression in Islet β-Cells: PRESERVATION OF GLUCOSE-STIMULATED INSULIN SECRETION

We have previously reported that glucose-stimulated insulin secretion (GSIS) is tightly correlated with pyruvate carboxylase (PC)-catalyzed anaplerotic flux into the tricarboxylic acid cycle and stimulation of pyruvate cycling activity. To further evaluate the role of PC in β-cell function, we const...

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Veröffentlicht in:	The Journal of biological chemistry 2006-08, Vol.281 (31), p.22342-22351
Hauptverfasser:	Jensen, Mette V, Joseph, Jamie W, Ilkayeva, Olga, Burgess, Shawn, Lu, Danhong, Ronnebaum, Sarah M, Odegaard, Matthew, Becker, Thomas C, Sherry, A. Dean, Newgard, Christopher B
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetylcarnitine - analysis Adenovirus Allosteric Regulation Animals Cell Line Glucose - pharmacology Insulin - metabolism Insulin Secretion Insulin-Secreting Cells - metabolism Islets of Langerhans NADP - biosynthesis Pyruvate Carboxylase - antagonists & inhibitors Pyruvate Carboxylase - physiology Rats RNA, Small Interfering - pharmacology
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