Formation of immunodeficiency in newborn mice exposed to nicotine during intrauterine development
Exposure to nicotine during intrauterine development leads to immunodeficiency manifested in inhibition of delayed-type hypersensitivity reaction and reduced number of antibody-producing cells forming in response to sheep erythrocytes in newborn mice. The number of splenic CFU in the bone marrow of...
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| Veröffentlicht in: | Bulletin of experimental biology and medicine 2005-06, Vol.139 (6), p.692-694 |
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| container_issue | 6 |
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| container_title | Bulletin of experimental biology and medicine |
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| creator | Demina, D V Toporkova, L B Kozlov, V A Khaldoyanidi, S K Orlovskaya, I A |
| description | Exposure to nicotine during intrauterine development leads to immunodeficiency manifested in inhibition of delayed-type hypersensitivity reaction and reduced number of antibody-producing cells forming in response to sheep erythrocytes in newborn mice. The number of splenic CFU in the bone marrow of newborn mice exposed to nicotine in utero is decreased compared to the control. By contrast, nicotine induced an increase in splenic CFU count in fetal liver. We concluded that nicotine modifying the hemopoietic microenvironment delayed the release of primitive precursors from fetal liver, which impaired colonization of fetal bone marrow and led to imbalance in the production of mature blood cell, including immune system cells. |
| doi_str_mv | 10.1007/s10517-005-0380-5 |
| format | Article |
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The number of splenic CFU in the bone marrow of newborn mice exposed to nicotine in utero is decreased compared to the control. By contrast, nicotine induced an increase in splenic CFU count in fetal liver. We concluded that nicotine modifying the hemopoietic microenvironment delayed the release of primitive precursors from fetal liver, which impaired colonization of fetal bone marrow and led to imbalance in the production of mature blood cell, including immune system cells.</description><identifier>ISSN: 0007-4888</identifier><identifier>EISSN: 1573-8221</identifier><identifier>DOI: 10.1007/s10517-005-0380-5</identifier><identifier>PMID: 16224583</identifier><identifier>CODEN: BEXBAN</identifier><language>eng</language><publisher>United States: Springer Nature B.V</publisher><subject>Animals ; Animals, Newborn ; Bone Marrow Cells - drug effects ; Bone Marrow Cells - immunology ; Colony-Forming Units Assay ; Crosses, Genetic ; Female ; Fetus - cytology ; Fetus - drug effects ; Hypersensitivity, Delayed ; Immune System - drug effects ; Immune System - embryology ; Liver - drug effects ; Maternal-Fetal Exchange ; Mice ; Mice, Inbred C57BL ; Mice, Inbred CBA ; Nicotine - pharmacology ; Pregnancy</subject><ispartof>Bulletin of experimental biology and medicine, 2005-06, Vol.139 (6), p.692-694</ispartof><rights>Springer Science+Business Media, Inc. 2005</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c326t-189320c9928a2fa47b3d78b6819dec79522c945f1bd89d249a4eb41951ca9aa63</citedby><cites>FETCH-LOGICAL-c326t-189320c9928a2fa47b3d78b6819dec79522c945f1bd89d249a4eb41951ca9aa63</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>315,781,785,27929,27930</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/16224583$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Demina, D V</creatorcontrib><creatorcontrib>Toporkova, L B</creatorcontrib><creatorcontrib>Kozlov, V A</creatorcontrib><creatorcontrib>Khaldoyanidi, S K</creatorcontrib><creatorcontrib>Orlovskaya, I A</creatorcontrib><title>Formation of immunodeficiency in newborn mice exposed to nicotine during intrauterine development</title><title>Bulletin of experimental biology and medicine</title><addtitle>Bull Exp Biol Med</addtitle><description>Exposure to nicotine during intrauterine development leads to immunodeficiency manifested in inhibition of delayed-type hypersensitivity reaction and reduced number of antibody-producing cells forming in response to sheep erythrocytes in newborn mice. 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| subjects | Animals Animals, Newborn Bone Marrow Cells - drug effects Bone Marrow Cells - immunology Colony-Forming Units Assay Crosses, Genetic Female Fetus - cytology Fetus - drug effects Hypersensitivity, Delayed Immune System - drug effects Immune System - embryology Liver - drug effects Maternal-Fetal Exchange Mice Mice, Inbred C57BL Mice, Inbred CBA Nicotine - pharmacology Pregnancy |
| title | Formation of immunodeficiency in newborn mice exposed to nicotine during intrauterine development |
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