Two-way Interdomain Signal Transduction in Tetracycline Repressor

The transcription of genes encoding resistance to the antibiotic, tetracycline (Tc), is repressed by tetracycline repressor (TetR), which is a homodimeric α-helical protein possessing a small N-terminal DNA binding domain (DNB domain) and a larger C-terminal domain (TBD domain). Binding of Tc to the...

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Veröffentlicht in:	Journal of molecular biology 2006-08, Vol.361 (2), p.382-389
Hauptverfasser:	Reichheld, Sean E., Davidson, Alan R.
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Substitution anhydrotetracycline DNA binding domain Gene Expression Regulation, Bacterial Kinetics Models, Molecular Protein Conformation Protein Folding Protein Structure, Tertiary Repressor Proteins - chemistry Repressor Proteins - genetics Repressor Proteins - metabolism Signal Transduction tetracycline tetracycline binding and dimerization domain tetracycline repressor protein Tetracycline Resistance - physiology Tetracyclines - pharmacology Thermodynamics
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