Whole-Body Hypothermia for Neonates with Hypoxic–Ischemic Encephalopathy
In this multicenter, randomized trial, neonates with moderate or severe hypoxic–ischemic encephalopathy randomly assigned to whole-body hypothermia had a significantly reduced risk of death or moderate or severe disability at 18 to 22 months of age. This study suggests that whole-body hypothermia ma...
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| Veröffentlicht in: | The New England journal of medicine 2005-10, Vol.353 (15), p.1574-1584 |
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| creator | Shankaran, Seetha Laptook, Abbot R Ehrenkranz, Richard A Tyson, Jon E McDonald, Scott A Donovan, Edward F Fanaroff, Avroy A Poole, W. Kenneth Wright, Linda L Higgins, Rosemary D Finer, Neil N Carlo, Waldemar A Duara, Shahnaz Oh, William Cotten, C. Michael Stevenson, David K Stoll, Barbara J Lemons, James A Guillet, Ronnie Jobe, Alan H |
| description | In this multicenter, randomized trial, neonates with moderate or severe hypoxic–ischemic encephalopathy randomly assigned to whole-body hypothermia had a significantly reduced risk of death or moderate or severe disability at 18 to 22 months of age. This study suggests that whole-body hypothermia may improve substantially the outcomes for infants with hypoxic–ischemic encephalopathy.
Neonates with moderate or severe hypoxic–ischemic encephalopathy randomly assigned to whole-body hypothermia had a significantly reduced risk of death or moderate or severe disability at 18 to 22 months of age.
Among term infants, hypoxic–ischemic encephalopathy due to acute perinatal asphyxia remains an important cause of neurodevelopmental deficits in childhood. Infants with moderate encephalopathy have a 10 percent risk of death, and those who survive have a 30 percent risk of disabilities. Sixty percent of infants with severe encephalopathy die, and many, if not all, survivors are handicapped.
1
,
2
Treatment is currently limited to supportive intensive care.
Reductions in brain temperature by 2°C to 5°C provide neuroprotection in newborn and adult animal models of brain ischemia.
3
–
10
Brain cooling has a favorable effect on multiple pathways contributing to brain injury, including . . . |
| doi_str_mv | 10.1056/NEJMcps050929 |
| format | Article |
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Neonates with moderate or severe hypoxic–ischemic encephalopathy randomly assigned to whole-body hypothermia had a significantly reduced risk of death or moderate or severe disability at 18 to 22 months of age.
Among term infants, hypoxic–ischemic encephalopathy due to acute perinatal asphyxia remains an important cause of neurodevelopmental deficits in childhood. Infants with moderate encephalopathy have a 10 percent risk of death, and those who survive have a 30 percent risk of disabilities. Sixty percent of infants with severe encephalopathy die, and many, if not all, survivors are handicapped.
1
,
2
Treatment is currently limited to supportive intensive care.
Reductions in brain temperature by 2°C to 5°C provide neuroprotection in newborn and adult animal models of brain ischemia.
3
–
10
Brain cooling has a favorable effect on multiple pathways contributing to brain injury, including . . .</description><identifier>ISSN: 0028-4793</identifier><identifier>EISSN: 1533-4406</identifier><identifier>DOI: 10.1056/NEJMcps050929</identifier><identifier>PMID: 16221780</identifier><identifier>CODEN: NEJMAG</identifier><language>eng</language><publisher>Boston, MA: Massachusetts Medical Society</publisher><subject>Acidosis - etiology ; Age ; Asphyxia Neonatorum - complications ; Babies ; Biological and medical sciences ; Blindness - prevention & control ; Brain damage ; Brain research ; Cerebral Palsy - prevention & control ; Consciousness ; Consent ; Cooling ; Developmental Disabilities - prevention & control ; Female ; Follow-Up Studies ; General aspects ; Hearing Loss - prevention & control ; Humans ; Hypothermia, Induced - adverse effects ; Hypoxia-Ischemia, Brain - complications ; Hypoxia-Ischemia, Brain - mortality ; Hypoxia-Ischemia, Brain - therapy ; Infant, Newborn ; Intensive care ; Ischemia ; Male ; Medical sciences ; Nitric oxide ; Obstetric Labor Complications ; Pregnancy ; Pregnancy Complications</subject><ispartof>The New England journal of medicine, 2005-10, Vol.353 (15), p.1574-1584</ispartof><rights>Copyright © 2005 Massachusetts Medical Society. All rights reserved.</rights><rights>2005 INIST-CNRS</rights><rights>Copyright 2005 Massachusetts Medical Society.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c583t-a40f6174f11dc10eec43343151be66e7849ea4f7d1c64a83399c377de8c335523</citedby><cites>FETCH-LOGICAL-c583t-a40f6174f11dc10eec43343151be66e7849ea4f7d1c64a83399c377de8c335523</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.nejm.org/doi/pdf/10.1056/NEJMcps050929$$EPDF$$P50$$Gmms$$H</linktopdf><linktohtml>$$Uhttps://www.nejm.org/doi/full/10.1056/NEJMcps050929$$EHTML$$P50$$Gmms$$H</linktohtml><link.rule.ids>314,776,780,2746,2747,26080,27901,27902,52357,54039</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=17252301$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/16221780$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Shankaran, Seetha</creatorcontrib><creatorcontrib>Laptook, Abbot R</creatorcontrib><creatorcontrib>Ehrenkranz, Richard A</creatorcontrib><creatorcontrib>Tyson, Jon E</creatorcontrib><creatorcontrib>McDonald, Scott A</creatorcontrib><creatorcontrib>Donovan, Edward F</creatorcontrib><creatorcontrib>Fanaroff, Avroy A</creatorcontrib><creatorcontrib>Poole, W. Kenneth</creatorcontrib><creatorcontrib>Wright, Linda L</creatorcontrib><creatorcontrib>Higgins, Rosemary D</creatorcontrib><creatorcontrib>Finer, Neil N</creatorcontrib><creatorcontrib>Carlo, Waldemar A</creatorcontrib><creatorcontrib>Duara, Shahnaz</creatorcontrib><creatorcontrib>Oh, William</creatorcontrib><creatorcontrib>Cotten, C. Michael</creatorcontrib><creatorcontrib>Stevenson, David K</creatorcontrib><creatorcontrib>Stoll, Barbara J</creatorcontrib><creatorcontrib>Lemons, James A</creatorcontrib><creatorcontrib>Guillet, Ronnie</creatorcontrib><creatorcontrib>Jobe, Alan H</creatorcontrib><creatorcontrib>National Institute of Child Health and Human Development Neonatal Research Network</creatorcontrib><title>Whole-Body Hypothermia for Neonates with Hypoxic–Ischemic Encephalopathy</title><title>The New England journal of medicine</title><addtitle>N Engl J Med</addtitle><description>In this multicenter, randomized trial, neonates with moderate or severe hypoxic–ischemic encephalopathy randomly assigned to whole-body hypothermia had a significantly reduced risk of death or moderate or severe disability at 18 to 22 months of age. This study suggests that whole-body hypothermia may improve substantially the outcomes for infants with hypoxic–ischemic encephalopathy.
Neonates with moderate or severe hypoxic–ischemic encephalopathy randomly assigned to whole-body hypothermia had a significantly reduced risk of death or moderate or severe disability at 18 to 22 months of age.
Among term infants, hypoxic–ischemic encephalopathy due to acute perinatal asphyxia remains an important cause of neurodevelopmental deficits in childhood. Infants with moderate encephalopathy have a 10 percent risk of death, and those who survive have a 30 percent risk of disabilities. Sixty percent of infants with severe encephalopathy die, and many, if not all, survivors are handicapped.
1
,
2
Treatment is currently limited to supportive intensive care.
Reductions in brain temperature by 2°C to 5°C provide neuroprotection in newborn and adult animal models of brain ischemia.
3
–
10
Brain cooling has a favorable effect on multiple pathways contributing to brain injury, including . . .</description><subject>Acidosis - etiology</subject><subject>Age</subject><subject>Asphyxia Neonatorum - complications</subject><subject>Babies</subject><subject>Biological and medical sciences</subject><subject>Blindness - prevention & control</subject><subject>Brain damage</subject><subject>Brain research</subject><subject>Cerebral Palsy - prevention & control</subject><subject>Consciousness</subject><subject>Consent</subject><subject>Cooling</subject><subject>Developmental Disabilities - prevention & control</subject><subject>Female</subject><subject>Follow-Up Studies</subject><subject>General aspects</subject><subject>Hearing Loss - prevention & control</subject><subject>Humans</subject><subject>Hypothermia, Induced - adverse effects</subject><subject>Hypoxia-Ischemia, Brain - complications</subject><subject>Hypoxia-Ischemia, Brain - mortality</subject><subject>Hypoxia-Ischemia, Brain - therapy</subject><subject>Infant, Newborn</subject><subject>Intensive care</subject><subject>Ischemia</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Nitric oxide</subject><subject>Obstetric Labor Complications</subject><subject>Pregnancy</subject><subject>Pregnancy Complications</subject><issn>0028-4793</issn><issn>1533-4406</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2005</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BEC</sourceid><sourceid>BENPR</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNqF0c1O3DAQAGALgboL7ZFrFSGVW8BjO_45AloKaIFLqx4jrzNRskriYGdF98Y79A37JE27K62KhJjLHObTjGaGkGOgZ0Azef4wu7t3faQZNczskSlknKdCULlPppQynQpl-IQcxrikY4AwH8gEJGOgNJ2Sux-VbzC99MU6uVn3fqgwtLVNSh-SB_SdHTAmz_VQ_av-rN3vl1-30VXY1i6ZdQ77yja-t0O1_kgOSttE_LTNR-T79ezb1U06f_x6e3UxT12m-ZBaQUsJSpQAhQOK6ATngkMGC5QSlRYGrShVAU4Kqzk3xnGlCtSO8yxj_Iicbvr2wT-tMA55W0eHTWM79KuYSy21Eoy-C0FRowXoEZ68gku_Ct24RM4YN4IJmo0o3SAXfIwBy7wPdWvDOgea_31F_t8rRv9523S1aLHY6e3tR_BlC2x0timD7Vwdd06xcVkKO9e2Me9w2b4x8A_97Jxx</recordid><startdate>20051013</startdate><enddate>20051013</enddate><creator>Shankaran, Seetha</creator><creator>Laptook, Abbot R</creator><creator>Ehrenkranz, Richard A</creator><creator>Tyson, Jon E</creator><creator>McDonald, Scott A</creator><creator>Donovan, Edward F</creator><creator>Fanaroff, Avroy A</creator><creator>Poole, W. 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Kenneth ; Wright, Linda L ; Higgins, Rosemary D ; Finer, Neil N ; Carlo, Waldemar A ; Duara, Shahnaz ; Oh, William ; Cotten, C. 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Michael</creatorcontrib><creatorcontrib>Stevenson, David K</creatorcontrib><creatorcontrib>Stoll, Barbara J</creatorcontrib><creatorcontrib>Lemons, James A</creatorcontrib><creatorcontrib>Guillet, Ronnie</creatorcontrib><creatorcontrib>Jobe, Alan H</creatorcontrib><creatorcontrib>National Institute of Child Health and Human Development Neonatal Research Network</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Pharma and Biotech Premium PRO</collection><collection>Nursing & Allied Health Database</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>British Nursing Database</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>eLibrary</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>SciTech Premium Collection</collection><collection>New England Journal of Medicine</collection><collection>ProQuest Biological Science Collection</collection><collection>Consumer Health Database</collection><collection>Healthcare Administration Database</collection><collection>Medical Database</collection><collection>ProQuest Psychology</collection><collection>Research Library</collection><collection>Science Database</collection><collection>Biological Science Database</collection><collection>Research Library (Corporate)</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest One Psychology</collection><collection>ProQuest Central Basic</collection><collection>Neurosciences Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>The New England journal of medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Shankaran, Seetha</au><au>Laptook, Abbot R</au><au>Ehrenkranz, Richard A</au><au>Tyson, Jon E</au><au>McDonald, Scott A</au><au>Donovan, Edward F</au><au>Fanaroff, Avroy A</au><au>Poole, W. Kenneth</au><au>Wright, Linda L</au><au>Higgins, Rosemary D</au><au>Finer, Neil N</au><au>Carlo, Waldemar A</au><au>Duara, Shahnaz</au><au>Oh, William</au><au>Cotten, C. Michael</au><au>Stevenson, David K</au><au>Stoll, Barbara J</au><au>Lemons, James A</au><au>Guillet, Ronnie</au><au>Jobe, Alan H</au><aucorp>National Institute of Child Health and Human Development Neonatal Research Network</aucorp><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Whole-Body Hypothermia for Neonates with Hypoxic–Ischemic Encephalopathy</atitle><jtitle>The New England journal of medicine</jtitle><addtitle>N Engl J Med</addtitle><date>2005-10-13</date><risdate>2005</risdate><volume>353</volume><issue>15</issue><spage>1574</spage><epage>1584</epage><pages>1574-1584</pages><issn>0028-4793</issn><eissn>1533-4406</eissn><coden>NEJMAG</coden><abstract>In this multicenter, randomized trial, neonates with moderate or severe hypoxic–ischemic encephalopathy randomly assigned to whole-body hypothermia had a significantly reduced risk of death or moderate or severe disability at 18 to 22 months of age. This study suggests that whole-body hypothermia may improve substantially the outcomes for infants with hypoxic–ischemic encephalopathy.
Neonates with moderate or severe hypoxic–ischemic encephalopathy randomly assigned to whole-body hypothermia had a significantly reduced risk of death or moderate or severe disability at 18 to 22 months of age.
Among term infants, hypoxic–ischemic encephalopathy due to acute perinatal asphyxia remains an important cause of neurodevelopmental deficits in childhood. Infants with moderate encephalopathy have a 10 percent risk of death, and those who survive have a 30 percent risk of disabilities. Sixty percent of infants with severe encephalopathy die, and many, if not all, survivors are handicapped.
1
,
2
Treatment is currently limited to supportive intensive care.
Reductions in brain temperature by 2°C to 5°C provide neuroprotection in newborn and adult animal models of brain ischemia.
3
–
10
Brain cooling has a favorable effect on multiple pathways contributing to brain injury, including . . .</abstract><cop>Boston, MA</cop><pub>Massachusetts Medical Society</pub><pmid>16221780</pmid><doi>10.1056/NEJMcps050929</doi><tpages>11</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0028-4793 |
| ispartof | The New England journal of medicine, 2005-10, Vol.353 (15), p.1574-1584 |
| issn | 0028-4793 1533-4406 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_68687420 |
| source | MEDLINE; EZB-FREE-00999 freely available EZB journals; New England Journal of Medicine |
| subjects | Acidosis - etiology Age Asphyxia Neonatorum - complications Babies Biological and medical sciences Blindness - prevention & control Brain damage Brain research Cerebral Palsy - prevention & control Consciousness Consent Cooling Developmental Disabilities - prevention & control Female Follow-Up Studies General aspects Hearing Loss - prevention & control Humans Hypothermia, Induced - adverse effects Hypoxia-Ischemia, Brain - complications Hypoxia-Ischemia, Brain - mortality Hypoxia-Ischemia, Brain - therapy Infant, Newborn Intensive care Ischemia Male Medical sciences Nitric oxide Obstetric Labor Complications Pregnancy Pregnancy Complications |
| title | Whole-Body Hypothermia for Neonates with Hypoxic–Ischemic Encephalopathy |
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