Chemometrics-assisted UV-spectroscopic strategies for the determination of theophylline in syrups

Two spectrophotometric methods, assisted by chemometric tools, were developed for the determination of theophylline in syrups: derivative spectroscopy (DS) and partial least-squares regression (PLS), the latter using both artificial and natural calibration sets. HPLC technique was employed to apply...

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Veröffentlicht in:	Journal of pharmaceutical and biomedical analysis 2005-10, Vol.39 (5), p.1068-1074
Hauptverfasser:	Culzoni, María J., De Zan, María M., Robles, Juan Carlos, Mantovani, Víctor E., Goicoechea, Héctor C.
Format:	Artikel
Sprache:	eng
Schlagworte:	Analysis Analytical, structural and metabolic biochemistry Biological and medical sciences Bronchodilator Agents - analysis Calibration Chemometrics Chromatography, High Pressure Liquid Derivative spectroscopy Fundamental and applied biological sciences. Psychology General pharmacology Indicators and Reagents Least-Squares Analysis Medical sciences Partial least-squares regression Pharmaceutical Solutions Pharmacology. Drug treatments Reproducibility of Results Spectrophotometry, Ultraviolet Syrup samples Theophylline Theophylline - analysis
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