Probing the "additive effect" in the proline and proline hydroxamic acid catalyzed asymmetric addition of nitroalkanes to cyclic enones

The effect of chirality and steric bulk of 2,5‐disubstituted piperazines as additives in the conjugate addition of 2‐nitropropane to cyclohexenone, catalyzed by l‐proline, was investigated. Neither chirality nor steric bulk affects the enantioselectivity of addition, which gives 86–93% ee in the pre...

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Veröffentlicht in:	Chirality (New York, N.Y.) N.Y.), 2005, Vol.17 (9), p.540-543
Hauptverfasser:	Hanessian, Stephen, Govindan, Subramaniyan, Warrier, Jayakumar S.
Format:	Artikel
Sprache:	eng
Schlagworte:	Alkanes - chemistry Catalysis conjugate addition Cyclization Hydroxamic Acids - chemistry Molecular Structure Nitro Compounds - chemistry organocatalysis piperazine proline Proline - chemistry proline hydroxamic acid Stereoisomerism
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