Dietary Iron, Zinc, and Calcium and the Risk of Lung Cancer
Background: Iron, zinc, and calcium are all involved in the metabolism of reactive oxygen species and may compete with each other for similar binding sites. Dietary intakes of these micronutrients have been associated with altered risks of colorectal, breast, and prostate cancers. Methods: In this M...
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| Veröffentlicht in: | Epidemiology (Cambridge, Mass.) Mass.), 2005-11, Vol.16 (6), p.772-779 |
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| creator | Zhou, Wei Park, Sohee Liu, Geoffrey Miller, David P. Wang, Lisa I. Pothier, Lucille Wain, John C. Lynch, Thomas J. Giovannucci, Edward Christiani, David C. |
| description | Background: Iron, zinc, and calcium are all involved in the metabolism of reactive oxygen species and may compete with each other for similar binding sites. Dietary intakes of these micronutrients have been associated with altered risks of colorectal, breast, and prostate cancers. Methods: In this Massachusetts hospital-based case-control study of 923 patients with lung cancer and 1125 healthy controls, we studied the associations between dietary iron, zinc, and calcium intake and the risk of lung cancer. Dietary intake was assessed at the time of recruitment (1992 to 2000) with the use of a 126-item semiquantitative food-frequency questionnaire. We analyzed the data using multiple logistic regression models adjusting for smoking history and other potential risk factors. Results: The adjusted odds ratios of dietary iron, zinc, and calcium from food sources were 1.45 (95% confidence interval = 1.03-2.06), 0.71 (0.50-0.99), and 1.64 (1.17-2.29), respectively, for the highest quintile versus the lowest quintile of each micronutrient. Stronger associations between micronutrients and lung cancer risk were found when iron, zinc, and calcium were included together in the same model. The associations between dietary micronutrients intake and lung cancer risk were stronger among current smokers than among former smokers. When we examined intake from supplements as well as diet, associations were similar to those for diet alone. Conclusions: Dietary iron, zinc, and calcium may play an important role in the development of lung cancer, especially among current smokers. These results need to be confirmed in large prospective studies. |
| doi_str_mv | 10.1097/01.ede.0000181311.11585.59 |
| format | Article |
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Dietary intakes of these micronutrients have been associated with altered risks of colorectal, breast, and prostate cancers. Methods: In this Massachusetts hospital-based case-control study of 923 patients with lung cancer and 1125 healthy controls, we studied the associations between dietary iron, zinc, and calcium intake and the risk of lung cancer. Dietary intake was assessed at the time of recruitment (1992 to 2000) with the use of a 126-item semiquantitative food-frequency questionnaire. We analyzed the data using multiple logistic regression models adjusting for smoking history and other potential risk factors. Results: The adjusted odds ratios of dietary iron, zinc, and calcium from food sources were 1.45 (95% confidence interval = 1.03-2.06), 0.71 (0.50-0.99), and 1.64 (1.17-2.29), respectively, for the highest quintile versus the lowest quintile of each micronutrient. Stronger associations between micronutrients and lung cancer risk were found when iron, zinc, and calcium were included together in the same model. The associations between dietary micronutrients intake and lung cancer risk were stronger among current smokers than among former smokers. When we examined intake from supplements as well as diet, associations were similar to those for diet alone. Conclusions: Dietary iron, zinc, and calcium may play an important role in the development of lung cancer, especially among current smokers. These results need to be confirmed in large prospective studies.</description><identifier>ISSN: 1044-3983</identifier><identifier>EISSN: 1531-5487</identifier><identifier>DOI: 10.1097/01.ede.0000181311.11585.59</identifier><identifier>PMID: 16222167</identifier><language>eng</language><publisher>Philadelphia, PA: Lippincott Williams & Wilkins</publisher><subject>Adult ; Aged ; Aged, 80 and over ; Biological and medical sciences ; Calcium ; Calcium, Dietary - administration & dosage ; Case-Control Studies ; Cigarette smoking ; Dietary iron ; Female ; Humans ; Iron, Dietary - administration & dosage ; Logistic Models ; Lung neoplasms ; Lung Neoplasms - epidemiology ; Male ; Medical sciences ; Micronutrients ; Middle Aged ; Miscellaneous ; Modeling ; Pneumology ; Prostate cancer ; Public health. Hygiene ; Public health. Hygiene-occupational medicine ; Risk Factors ; Smoking - adverse effects ; Smoking - epidemiology ; Smoking cessation ; Statistical median ; Surveys and Questionnaires ; Tumors of the respiratory system and mediastinum ; Zinc ; Zinc - administration & dosage</subject><ispartof>Epidemiology (Cambridge, Mass.), 2005-11, Vol.16 (6), p.772-779</ispartof><rights>Copyright 2005 Lippincott Williams & Wilkins, Inc.</rights><rights>2005 Lippincott Williams & Wilkins, Inc.</rights><rights>2006 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4970-959b1a4612d9c517b9ae691d3ad32c63e825c120080cef322ae2edb9da70492d3</citedby><cites>FETCH-LOGICAL-c4970-959b1a4612d9c517b9ae691d3ad32c63e825c120080cef322ae2edb9da70492d3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.jstor.org/stable/pdf/20486142$$EPDF$$P50$$Gjstor$$H</linktopdf><linktohtml>$$Uhttps://www.jstor.org/stable/20486142$$EHTML$$P50$$Gjstor$$H</linktohtml><link.rule.ids>314,780,784,803,27924,27925,58017,58250</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=17595640$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/16222167$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Zhou, Wei</creatorcontrib><creatorcontrib>Park, Sohee</creatorcontrib><creatorcontrib>Liu, Geoffrey</creatorcontrib><creatorcontrib>Miller, David P.</creatorcontrib><creatorcontrib>Wang, Lisa I.</creatorcontrib><creatorcontrib>Pothier, Lucille</creatorcontrib><creatorcontrib>Wain, John C.</creatorcontrib><creatorcontrib>Lynch, Thomas J.</creatorcontrib><creatorcontrib>Giovannucci, Edward</creatorcontrib><creatorcontrib>Christiani, David C.</creatorcontrib><title>Dietary Iron, Zinc, and Calcium and the Risk of Lung Cancer</title><title>Epidemiology (Cambridge, Mass.)</title><addtitle>Epidemiology</addtitle><description>Background: Iron, zinc, and calcium are all involved in the metabolism of reactive oxygen species and may compete with each other for similar binding sites. Dietary intakes of these micronutrients have been associated with altered risks of colorectal, breast, and prostate cancers. Methods: In this Massachusetts hospital-based case-control study of 923 patients with lung cancer and 1125 healthy controls, we studied the associations between dietary iron, zinc, and calcium intake and the risk of lung cancer. Dietary intake was assessed at the time of recruitment (1992 to 2000) with the use of a 126-item semiquantitative food-frequency questionnaire. We analyzed the data using multiple logistic regression models adjusting for smoking history and other potential risk factors. Results: The adjusted odds ratios of dietary iron, zinc, and calcium from food sources were 1.45 (95% confidence interval = 1.03-2.06), 0.71 (0.50-0.99), and 1.64 (1.17-2.29), respectively, for the highest quintile versus the lowest quintile of each micronutrient. Stronger associations between micronutrients and lung cancer risk were found when iron, zinc, and calcium were included together in the same model. The associations between dietary micronutrients intake and lung cancer risk were stronger among current smokers than among former smokers. When we examined intake from supplements as well as diet, associations were similar to those for diet alone. Conclusions: Dietary iron, zinc, and calcium may play an important role in the development of lung cancer, especially among current smokers. These results need to be confirmed in large prospective studies.</description><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Biological and medical sciences</subject><subject>Calcium</subject><subject>Calcium, Dietary - administration & dosage</subject><subject>Case-Control Studies</subject><subject>Cigarette smoking</subject><subject>Dietary iron</subject><subject>Female</subject><subject>Humans</subject><subject>Iron, Dietary - administration & dosage</subject><subject>Logistic Models</subject><subject>Lung neoplasms</subject><subject>Lung Neoplasms - epidemiology</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Micronutrients</subject><subject>Middle Aged</subject><subject>Miscellaneous</subject><subject>Modeling</subject><subject>Pneumology</subject><subject>Prostate cancer</subject><subject>Public health. Hygiene</subject><subject>Public health. Hygiene-occupational medicine</subject><subject>Risk Factors</subject><subject>Smoking - adverse effects</subject><subject>Smoking - epidemiology</subject><subject>Smoking cessation</subject><subject>Statistical median</subject><subject>Surveys and Questionnaires</subject><subject>Tumors of the respiratory system and mediastinum</subject><subject>Zinc</subject><subject>Zinc - administration & dosage</subject><issn>1044-3983</issn><issn>1531-5487</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2005</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkE1r3DAQhkVIaNK0PyHFBNpT7Gr0Zak9lc0nLARKe-lFaKVx14nXTiWb0H9fbbxkj9VFI-l5Z9BDyDnQCqipP1OoMGBF8wINHKACkFpW0hyQE5AcSil0fZhrKkTJjebH5G1KDxmvOcg35BgUYwxUfUK-XrY4uvi3uItDf1H8ant_Ubg-FAvX-XbavNTjGovvbXoshqZYTv3v_Nh7jO_IUeO6hO93-yn5eX31Y3FbLu9v7hbflqUXpqalkWYFTihgwXgJ9co4VAYCd4EzrzhqJj0wSjX12HDGHDIMKxNcTYVhgZ-ST3Pfpzj8mTCNdtMmj13nehymZJVWOv9Y_hdkIDjVTGXwywz6OKQUsbFPsd1kDRao3Tq2FGx2bPeO7YtjK00Of9hNmVYbDPvoTmoGPu4Al7zrmphttWnP1dJIJWjmxMw9D92IMT120zNGu0bXjet5tBK6zGYkQD6V25tt7GyOPaRxiK9tGRVagWD8H9lvmzU</recordid><startdate>200511</startdate><enddate>200511</enddate><creator>Zhou, Wei</creator><creator>Park, Sohee</creator><creator>Liu, Geoffrey</creator><creator>Miller, David P.</creator><creator>Wang, Lisa I.</creator><creator>Pothier, Lucille</creator><creator>Wain, John C.</creator><creator>Lynch, Thomas J.</creator><creator>Giovannucci, Edward</creator><creator>Christiani, David C.</creator><general>Lippincott Williams & Wilkins</general><general>Lippincott Williams & Wilkins, Inc</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QP</scope><scope>7U1</scope><scope>7U2</scope><scope>C1K</scope><scope>7X8</scope></search><sort><creationdate>200511</creationdate><title>Dietary Iron, Zinc, and Calcium and the Risk of Lung Cancer</title><author>Zhou, Wei ; Park, Sohee ; Liu, Geoffrey ; Miller, David P. ; Wang, Lisa I. ; Pothier, Lucille ; Wain, John C. ; Lynch, Thomas J. ; Giovannucci, Edward ; Christiani, David C.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4970-959b1a4612d9c517b9ae691d3ad32c63e825c120080cef322ae2edb9da70492d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2005</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Biological and medical sciences</topic><topic>Calcium</topic><topic>Calcium, Dietary - administration & dosage</topic><topic>Case-Control Studies</topic><topic>Cigarette smoking</topic><topic>Dietary iron</topic><topic>Female</topic><topic>Humans</topic><topic>Iron, Dietary - administration & dosage</topic><topic>Logistic Models</topic><topic>Lung neoplasms</topic><topic>Lung Neoplasms - epidemiology</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Micronutrients</topic><topic>Middle Aged</topic><topic>Miscellaneous</topic><topic>Modeling</topic><topic>Pneumology</topic><topic>Prostate cancer</topic><topic>Public health. Hygiene</topic><topic>Public health. Hygiene-occupational medicine</topic><topic>Risk Factors</topic><topic>Smoking - adverse effects</topic><topic>Smoking - epidemiology</topic><topic>Smoking cessation</topic><topic>Statistical median</topic><topic>Surveys and Questionnaires</topic><topic>Tumors of the respiratory system and mediastinum</topic><topic>Zinc</topic><topic>Zinc - administration & dosage</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Zhou, Wei</creatorcontrib><creatorcontrib>Park, Sohee</creatorcontrib><creatorcontrib>Liu, Geoffrey</creatorcontrib><creatorcontrib>Miller, David P.</creatorcontrib><creatorcontrib>Wang, Lisa I.</creatorcontrib><creatorcontrib>Pothier, Lucille</creatorcontrib><creatorcontrib>Wain, John C.</creatorcontrib><creatorcontrib>Lynch, Thomas J.</creatorcontrib><creatorcontrib>Giovannucci, Edward</creatorcontrib><creatorcontrib>Christiani, David C.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Risk Abstracts</collection><collection>Safety Science and Risk</collection><collection>Environmental Sciences and Pollution Management</collection><collection>MEDLINE - Academic</collection><jtitle>Epidemiology (Cambridge, Mass.)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Zhou, Wei</au><au>Park, Sohee</au><au>Liu, Geoffrey</au><au>Miller, David P.</au><au>Wang, Lisa I.</au><au>Pothier, Lucille</au><au>Wain, John C.</au><au>Lynch, Thomas J.</au><au>Giovannucci, Edward</au><au>Christiani, David C.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Dietary Iron, Zinc, and Calcium and the Risk of Lung Cancer</atitle><jtitle>Epidemiology (Cambridge, Mass.)</jtitle><addtitle>Epidemiology</addtitle><date>2005-11</date><risdate>2005</risdate><volume>16</volume><issue>6</issue><spage>772</spage><epage>779</epage><pages>772-779</pages><issn>1044-3983</issn><eissn>1531-5487</eissn><abstract>Background: Iron, zinc, and calcium are all involved in the metabolism of reactive oxygen species and may compete with each other for similar binding sites. Dietary intakes of these micronutrients have been associated with altered risks of colorectal, breast, and prostate cancers. Methods: In this Massachusetts hospital-based case-control study of 923 patients with lung cancer and 1125 healthy controls, we studied the associations between dietary iron, zinc, and calcium intake and the risk of lung cancer. Dietary intake was assessed at the time of recruitment (1992 to 2000) with the use of a 126-item semiquantitative food-frequency questionnaire. We analyzed the data using multiple logistic regression models adjusting for smoking history and other potential risk factors. Results: The adjusted odds ratios of dietary iron, zinc, and calcium from food sources were 1.45 (95% confidence interval = 1.03-2.06), 0.71 (0.50-0.99), and 1.64 (1.17-2.29), respectively, for the highest quintile versus the lowest quintile of each micronutrient. Stronger associations between micronutrients and lung cancer risk were found when iron, zinc, and calcium were included together in the same model. The associations between dietary micronutrients intake and lung cancer risk were stronger among current smokers than among former smokers. When we examined intake from supplements as well as diet, associations were similar to those for diet alone. Conclusions: Dietary iron, zinc, and calcium may play an important role in the development of lung cancer, especially among current smokers. These results need to be confirmed in large prospective studies.</abstract><cop>Philadelphia, PA</cop><pub>Lippincott Williams & Wilkins</pub><pmid>16222167</pmid><doi>10.1097/01.ede.0000181311.11585.59</doi><tpages>8</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Adult Aged Aged, 80 and over Biological and medical sciences Calcium Calcium, Dietary - administration & dosage Case-Control Studies Cigarette smoking Dietary iron Female Humans Iron, Dietary - administration & dosage Logistic Models Lung neoplasms Lung Neoplasms - epidemiology Male Medical sciences Micronutrients Middle Aged Miscellaneous Modeling Pneumology Prostate cancer Public health. Hygiene Public health. Hygiene-occupational medicine Risk Factors Smoking - adverse effects Smoking - epidemiology Smoking cessation Statistical median Surveys and Questionnaires Tumors of the respiratory system and mediastinum Zinc Zinc - administration & dosage |
| title | Dietary Iron, Zinc, and Calcium and the Risk of Lung Cancer |
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