Biventricular diastolic dysfunction in patients with autosomal-dominant polycystic kidney disease
Biventricular diastolic dysfunction in patients with autosomal-dominant polycystic kidney disease. Left ventricular diastolic dysfunction has been shown in patients with autosomal-dominant polycystic kidney disease (ADPKD). However, there is no study evaluating right ventricular functions in these p...
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| Veröffentlicht in: | Kidney international 2005-11, Vol.68 (5), p.2244-2249 |
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| creator | Oflaz, Huseyin Alisir, Sabahat Buyukaydin, Banu Kocaman, Orhan Turgut, Faruk Namli, Sule Pamukcu, Burak Oncul, Aytac Ecder, Tevfik |
| description | Biventricular diastolic dysfunction in patients with autosomal-dominant polycystic kidney disease.
Left ventricular diastolic dysfunction has been shown in patients with autosomal-dominant polycystic kidney disease (ADPKD). However, there is no study evaluating right ventricular functions in these patients.
In the present study, diastolic functions of both ventricles in normotensive and hypertensive ADPKD patients with well-preserved renal function were investigated. Fifteen hypertensive and 16 normotensive patients with ADPKD with well-preserved renal function, 16 patients with essential hypertension, and 24 healthy subjects were included in the study. Conventional left and right ventricular echocardiographic measurements were performed in all subjects. Left and right ventricular functions were investigated both by myocardial performance index (MPI) [calculated by dividing the sum of isovolumic contraction time and isovolumic relaxation time (IVRT) by ejection time] and by tissue Doppler imaging (TDI).
Left ventricular deceleration time and IVRT were significantly prolonged in hypertensive patients with ADPKD compared with patients with essential hypertension and even in normotensive patients with ADPKD compared with healthy subjects. Left and right MPIs were significantly higher in patients with ADPKD compared with healthy subjects, showing systolic and diastolic dysfunction. Moreover, by using TDI, the peak early diastolic mitral annular velocity (Em) to peak late diastolic mitral annular velocity (Am) ratio and the peak early diastolic tricuspid annular velocity (Et) to peak late diastolic tricuspid annular velocity (At) ratio were decreased in patients with ADPKD, suggesting biventricular diastolic dysfunction.
Both hypertensive and normotensive patients with ADPKD show significant biventricular diastolic dysfunction, suggesting cardiac involvement very early in the course of ADPKD. |
| doi_str_mv | 10.1111/j.1523-1755.2005.00682.x |
| format | Article |
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Left ventricular diastolic dysfunction has been shown in patients with autosomal-dominant polycystic kidney disease (ADPKD). However, there is no study evaluating right ventricular functions in these patients.
In the present study, diastolic functions of both ventricles in normotensive and hypertensive ADPKD patients with well-preserved renal function were investigated. Fifteen hypertensive and 16 normotensive patients with ADPKD with well-preserved renal function, 16 patients with essential hypertension, and 24 healthy subjects were included in the study. Conventional left and right ventricular echocardiographic measurements were performed in all subjects. Left and right ventricular functions were investigated both by myocardial performance index (MPI) [calculated by dividing the sum of isovolumic contraction time and isovolumic relaxation time (IVRT) by ejection time] and by tissue Doppler imaging (TDI).
Left ventricular deceleration time and IVRT were significantly prolonged in hypertensive patients with ADPKD compared with patients with essential hypertension and even in normotensive patients with ADPKD compared with healthy subjects. Left and right MPIs were significantly higher in patients with ADPKD compared with healthy subjects, showing systolic and diastolic dysfunction. Moreover, by using TDI, the peak early diastolic mitral annular velocity (Em) to peak late diastolic mitral annular velocity (Am) ratio and the peak early diastolic tricuspid annular velocity (Et) to peak late diastolic tricuspid annular velocity (At) ratio were decreased in patients with ADPKD, suggesting biventricular diastolic dysfunction.
Both hypertensive and normotensive patients with ADPKD show significant biventricular diastolic dysfunction, suggesting cardiac involvement very early in the course of ADPKD.</description><identifier>ISSN: 0085-2538</identifier><identifier>EISSN: 1523-1755</identifier><identifier>DOI: 10.1111/j.1523-1755.2005.00682.x</identifier><identifier>PMID: 16221225</identifier><identifier>CODEN: KDYIA5</identifier><language>eng</language><publisher>New York, NY: Elsevier Inc</publisher><subject>Adult ; Antihypertensive Agents - therapeutic use ; autosomal-dominant polycystic kidney disease ; Biological and medical sciences ; Creatinine - metabolism ; Diastole ; diastolic dysfunction ; Female ; Humans ; Hypertension, Renal - complications ; Hypertension, Renal - drug therapy ; hypertensive ; Kidneys ; left ventricle ; Male ; Malformations of the urinary system ; Medical sciences ; Middle Aged ; Nephrology. Urinary tract diseases ; normotensive ; Polycystic Kidney, Autosomal Dominant - complications ; right ventricle ; Systole ; Ultrasonography ; Ventricular Dysfunction, Left - diagnostic imaging ; Ventricular Dysfunction, Left - etiology ; Ventricular Dysfunction, Right - diagnostic imaging ; Ventricular Dysfunction, Right - etiology</subject><ispartof>Kidney international, 2005-11, Vol.68 (5), p.2244-2249</ispartof><rights>2005 International Society of Nephrology</rights><rights>2005 INIST-CNRS</rights><rights>Copyright Nature Publishing Group Nov 2005</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c479t-e84ed5e046cbfe8457b14c20e8152d286e03eebb06968659ea3824ab2d064fb93</citedby><cites>FETCH-LOGICAL-c479t-e84ed5e046cbfe8457b14c20e8152d286e03eebb06968659ea3824ab2d064fb93</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=17239103$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/16221225$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Oflaz, Huseyin</creatorcontrib><creatorcontrib>Alisir, Sabahat</creatorcontrib><creatorcontrib>Buyukaydin, Banu</creatorcontrib><creatorcontrib>Kocaman, Orhan</creatorcontrib><creatorcontrib>Turgut, Faruk</creatorcontrib><creatorcontrib>Namli, Sule</creatorcontrib><creatorcontrib>Pamukcu, Burak</creatorcontrib><creatorcontrib>Oncul, Aytac</creatorcontrib><creatorcontrib>Ecder, Tevfik</creatorcontrib><title>Biventricular diastolic dysfunction in patients with autosomal-dominant polycystic kidney disease</title><title>Kidney international</title><addtitle>Kidney Int</addtitle><description>Biventricular diastolic dysfunction in patients with autosomal-dominant polycystic kidney disease.
Left ventricular diastolic dysfunction has been shown in patients with autosomal-dominant polycystic kidney disease (ADPKD). However, there is no study evaluating right ventricular functions in these patients.
In the present study, diastolic functions of both ventricles in normotensive and hypertensive ADPKD patients with well-preserved renal function were investigated. Fifteen hypertensive and 16 normotensive patients with ADPKD with well-preserved renal function, 16 patients with essential hypertension, and 24 healthy subjects were included in the study. Conventional left and right ventricular echocardiographic measurements were performed in all subjects. Left and right ventricular functions were investigated both by myocardial performance index (MPI) [calculated by dividing the sum of isovolumic contraction time and isovolumic relaxation time (IVRT) by ejection time] and by tissue Doppler imaging (TDI).
Left ventricular deceleration time and IVRT were significantly prolonged in hypertensive patients with ADPKD compared with patients with essential hypertension and even in normotensive patients with ADPKD compared with healthy subjects. Left and right MPIs were significantly higher in patients with ADPKD compared with healthy subjects, showing systolic and diastolic dysfunction. Moreover, by using TDI, the peak early diastolic mitral annular velocity (Em) to peak late diastolic mitral annular velocity (Am) ratio and the peak early diastolic tricuspid annular velocity (Et) to peak late diastolic tricuspid annular velocity (At) ratio were decreased in patients with ADPKD, suggesting biventricular diastolic dysfunction.
Both hypertensive and normotensive patients with ADPKD show significant biventricular diastolic dysfunction, suggesting cardiac involvement very early in the course of ADPKD.</description><subject>Adult</subject><subject>Antihypertensive Agents - therapeutic use</subject><subject>autosomal-dominant polycystic kidney disease</subject><subject>Biological and medical sciences</subject><subject>Creatinine - metabolism</subject><subject>Diastole</subject><subject>diastolic dysfunction</subject><subject>Female</subject><subject>Humans</subject><subject>Hypertension, Renal - complications</subject><subject>Hypertension, Renal - drug therapy</subject><subject>hypertensive</subject><subject>Kidneys</subject><subject>left ventricle</subject><subject>Male</subject><subject>Malformations of the urinary system</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Nephrology. 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Urinary tract diseases</topic><topic>normotensive</topic><topic>Polycystic Kidney, Autosomal Dominant - complications</topic><topic>right ventricle</topic><topic>Systole</topic><topic>Ultrasonography</topic><topic>Ventricular Dysfunction, Left - diagnostic imaging</topic><topic>Ventricular Dysfunction, Left - etiology</topic><topic>Ventricular Dysfunction, Right - diagnostic imaging</topic><topic>Ventricular Dysfunction, Right - etiology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Oflaz, Huseyin</creatorcontrib><creatorcontrib>Alisir, Sabahat</creatorcontrib><creatorcontrib>Buyukaydin, Banu</creatorcontrib><creatorcontrib>Kocaman, Orhan</creatorcontrib><creatorcontrib>Turgut, Faruk</creatorcontrib><creatorcontrib>Namli, Sule</creatorcontrib><creatorcontrib>Pamukcu, Burak</creatorcontrib><creatorcontrib>Oncul, Aytac</creatorcontrib><creatorcontrib>Ecder, Tevfik</creatorcontrib><collection>ScienceDirect Open Access Titles</collection><collection>Elsevier:ScienceDirect:Open Access</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Nursing & Allied Health Database</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><jtitle>Kidney international</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Oflaz, Huseyin</au><au>Alisir, Sabahat</au><au>Buyukaydin, Banu</au><au>Kocaman, Orhan</au><au>Turgut, Faruk</au><au>Namli, Sule</au><au>Pamukcu, Burak</au><au>Oncul, Aytac</au><au>Ecder, Tevfik</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Biventricular diastolic dysfunction in patients with autosomal-dominant polycystic kidney disease</atitle><jtitle>Kidney international</jtitle><addtitle>Kidney Int</addtitle><date>2005-11-01</date><risdate>2005</risdate><volume>68</volume><issue>5</issue><spage>2244</spage><epage>2249</epage><pages>2244-2249</pages><issn>0085-2538</issn><eissn>1523-1755</eissn><coden>KDYIA5</coden><abstract>Biventricular diastolic dysfunction in patients with autosomal-dominant polycystic kidney disease.
Left ventricular diastolic dysfunction has been shown in patients with autosomal-dominant polycystic kidney disease (ADPKD). However, there is no study evaluating right ventricular functions in these patients.
In the present study, diastolic functions of both ventricles in normotensive and hypertensive ADPKD patients with well-preserved renal function were investigated. Fifteen hypertensive and 16 normotensive patients with ADPKD with well-preserved renal function, 16 patients with essential hypertension, and 24 healthy subjects were included in the study. Conventional left and right ventricular echocardiographic measurements were performed in all subjects. Left and right ventricular functions were investigated both by myocardial performance index (MPI) [calculated by dividing the sum of isovolumic contraction time and isovolumic relaxation time (IVRT) by ejection time] and by tissue Doppler imaging (TDI).
Left ventricular deceleration time and IVRT were significantly prolonged in hypertensive patients with ADPKD compared with patients with essential hypertension and even in normotensive patients with ADPKD compared with healthy subjects. Left and right MPIs were significantly higher in patients with ADPKD compared with healthy subjects, showing systolic and diastolic dysfunction. Moreover, by using TDI, the peak early diastolic mitral annular velocity (Em) to peak late diastolic mitral annular velocity (Am) ratio and the peak early diastolic tricuspid annular velocity (Et) to peak late diastolic tricuspid annular velocity (At) ratio were decreased in patients with ADPKD, suggesting biventricular diastolic dysfunction.
Both hypertensive and normotensive patients with ADPKD show significant biventricular diastolic dysfunction, suggesting cardiac involvement very early in the course of ADPKD.</abstract><cop>New York, NY</cop><pub>Elsevier Inc</pub><pmid>16221225</pmid><doi>10.1111/j.1523-1755.2005.00682.x</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Adult Antihypertensive Agents - therapeutic use autosomal-dominant polycystic kidney disease Biological and medical sciences Creatinine - metabolism Diastole diastolic dysfunction Female Humans Hypertension, Renal - complications Hypertension, Renal - drug therapy hypertensive Kidneys left ventricle Male Malformations of the urinary system Medical sciences Middle Aged Nephrology. Urinary tract diseases normotensive Polycystic Kidney, Autosomal Dominant - complications right ventricle Systole Ultrasonography Ventricular Dysfunction, Left - diagnostic imaging Ventricular Dysfunction, Left - etiology Ventricular Dysfunction, Right - diagnostic imaging Ventricular Dysfunction, Right - etiology |
| title | Biventricular diastolic dysfunction in patients with autosomal-dominant polycystic kidney disease |
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