Effects of thiol chelation on alpha1-adrenoceptor-induced vasoconstriction in vivo

The aims of this study were to determine whether systemic injections of the lipophobic thiol chelator, para-hydroxymercurobenzoic acid (PHMBA) would reduce the vasoconstrictor responses elicited by the alpha1-adrenoceptor agonist, phenylephrine, in urethane-anesthetized rats by chelation of thiol re...

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Veröffentlicht in:	Journal of cardiovascular pharmacology 2005-11, Vol.46 (5), p.627-636
Hauptverfasser:	Hoque, Azizul, Owen, Joy R, Bates, James N, Lewis, Stephen J
Format:	Artikel
Sprache:	eng
Schlagworte:	Adrenergic alpha-Agonists - pharmacology Animals Dose-Response Relationship, Drug Hydroxymercuribenzoates - pharmacology Male Nifedipine - pharmacology Norepinephrine - pharmacology Phenylephrine - pharmacology Rats Rats, Sprague-Dawley Receptors, Adrenergic, alpha-1 - metabolism Sulfhydryl Reagents - pharmacology Vasoconstriction - drug effects Vasodilator Agents - pharmacology
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