The effect of powder blend and tablet structure on drug release mechanisms of hydrophobic starch acetate matrix tablets

This study investigates the release mechanism of a hydrophilic drug (caffeine) from hydrophobic matrix tablets composed of starch acetate. Different particle size fractions of starch acetate were mixed with caffeine (22% V/V) to obtain various mixture organisations in the powder, as well as in the f...

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Veröffentlicht in:	European journal of pharmaceutics and biopharmaceutics 2005-10, Vol.61 (3), p.149-157
Hauptverfasser:	van Veen, B., Pajander, J., Zuurman, K., Lappalainen, R., Poso, A., Frijlink, H.W., Ketolainen, J.
Format:	Artikel
Sprache:	eng
Schlagworte:	Caffeine - administration & dosage Caffeine - chemistry Drug release Hydrophobic and Hydrophilic Interactions Hydrophobic matrix tablet Particle Size Percolation Powder blend Powders - chemistry Solubility Starch - administration & dosage Starch - analogs & derivatives Tablets - chemistry
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