Relationship between microtubule-binding repeats and morphology of neurofibrillary tangle in Alzheimer's disease

Objective – The present study was performed to compare the distributions of three‐repeat (3R) and four‐repeat (4R) neurofibrillary tangles (NFT) with those of pretangles (p‐NFT), intracellular NFT (i‐NFT), and extracellular NFT (e‐NFT) in the hippocampus of Alzheimer's disease brains. Methods...

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Veröffentlicht in:	Acta neurologica Scandinavica 2005-11, Vol.112 (5), p.327-334
Hauptverfasser:	Kitamura, T., Sugimori, K., Sudo, S., Kobayashi, K.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Alzheimer Disease - pathology Alzheimer's disease Binding Sites - genetics Biological and medical sciences Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases Disorders of higher nervous function. Focal brain diseases. Central vestibular syndrome and deafness. Brain stem syndromes Entorhinal Cortex - pathology Female Hippocampus - pathology Humans immunohistochemistry Male Medical sciences Microsatellite Repeats - genetics Microtubules - genetics Middle Aged Nervous system (semeiology, syndromes) neurofibrillary tangles Neurofibrillary Tangles - genetics Neurofibrillary Tangles - pathology Neurofibrils - genetics Neurology Repetitive Sequences, Nucleic Acid - genetics Statistics as Topic tau isoform tau Proteins - genetics Trinucleotide Repeats - genetics
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