Chitosan and poly(methyl vinyl ether-co-maleic anhydride) microparticles as nasal sustained delivery systems

An original dosage form for nasal delivery based on the encapsulation of hydrophilic drug in chitosan-poly(methyl vinyl ether-co-maleic anhydride) (CH-PVM/MA) microparticles prepared by spray-drying technique was developed. Microparticles were characterized in terms of morphology, size, swelling pro...

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Veröffentlicht in:	European journal of pharmaceutics and biopharmaceutics 2005-10, Vol.61 (3), p.195-200
Hauptverfasser:	Cerchiara, T., Luppi, B., Chidichimo, G., Bigucci, F., Zecchi, V.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adhesiveness Administration, Intranasal Chitosan Chitosan - administration & dosage Drug Delivery Systems Franz cells Hydrogen-Ion Concentration Maleates - administration & dosage Microspheres Mucoadhesion Poly(methyl vinyl ether-co-maleic anhydride) Polyethylenes - administration & dosage Propranolol - administration & dosage Propranolol hydrochloride Solubility Spectroscopy, Fourier Transform Infrared Spray-drying
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