Vaccination with leukemia cells expressing cell-surface-associated GM-CSF blocks leukemia induction in immunocompetent mice

The fundamental basis for immunotherapy of leukemia is that leukemic cells express specific antigens that are not expressed by normal hematopoietic cells. However, the host immune system appears to be tolerant to leukemia cells. To overcome this tolerance, we vaccinated immunocompetent mice with mur...

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Veröffentlicht in:	Oncogene 2006-07, Vol.25 (32), p.4483-4490
Hauptverfasser:	Ling, X, Wang, Y, Dietrich, M F, Andreeff, M, Arlinghaus, R B
Format:	Artikel
Sprache:	eng
Schlagworte:	Animal models Animals Antigens Apoptosis BCR-ABL protein Biological and medical sciences Cancer Vaccines - administration & dosage Cancer Vaccines - immunology Cancer Vaccines - metabolism CD4 antigen CD40 Ligand - biosynthesis CD40 Ligand - genetics CD40L protein CD8 antigen Cell Biology Cell culture Cell Line Cell Line, Tumor Cell physiology Cell surface Cell suspensions Cell transformation and carcinogenesis. Action of oncogenes and antioncogenes Cell-mediated immunity Colony-stimulating factor Disease Models, Animal Female Fundamental and applied biological sciences. Psychology Fusion protein Genetic Vectors Granulocyte-macrophage colony-stimulating factor Granulocyte-Macrophage Colony-Stimulating Factor - administration & dosage Granulocyte-Macrophage Colony-Stimulating Factor - biosynthesis Granulocyte-Macrophage Colony-Stimulating Factor - genetics Hematologic and hematopoietic diseases Human Genetics Humans Immunocompetence Immunological tolerance Immunotherapy Immunotherapy, Adoptive Internal Medicine Leukemia Leukemia, Myelomonocytic, Acute - immunology Leukemia, Myelomonocytic, Acute - pathology Leukemia, Myelomonocytic, Acute - prevention & control Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis Lymphocytes T Medical sciences Medicine Medicine & Public Health Mice Mice, Inbred BALB C Mice, Inbred C3H Mice, Nude Molecular and cellular biology Oncology original-article Rodents Spleen Transduction, Genetic Vaccination Vaccines
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