Chimpanzee DC-SIGN alleles predict the existence of A and B isoforms, but do not support a role for resistance to HIV infection

We report here the gene sequence for DC-SIGN (CD209) from chimpanzees. DC-SIGN is a C-type lectin expressed by dendritic cells. It is involved in DC-T cell interactions as well as in HIV-1 and SIV transmission. We have cloned two new alleles for chimpanzee DC-SIGN. The coding sequences are highly ho...

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Veröffentlicht in:	AIDS research and human retroviruses 2005-09, Vol.21 (9), p.820-829
Hauptverfasser:	SANTOS, Patricia R, MICHEL-SALZAT, Alice, BUTOR, Cécile
Format:	Artikel
Sprache:	eng
Schlagworte:	AIDS/HIV Alleles Animals Base Sequence Biological and medical sciences Cell Adhesion Molecules - genetics Dendritic Cells - metabolism Fundamental and applied biological sciences. Psychology HIV Infections - immunology HIV Infections - virology HIV-1 Human immunodeficiency virus 1 Human viral diseases Immunity, Innate Infectious diseases Lectins, C-Type - genetics Medical sciences Microbiology Miscellaneous Molecular Sequence Data Pan troglodytes Pan troglodytes - genetics Protein Isoforms - genetics Receptors, Cell Surface - genetics Retrovirus Sequence Alignment Simian immunodeficiency virus Viral diseases Viral diseases of the lymphoid tissue and the blood. Aids Virology
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