Different effects of nine clausenamide ennatiomers on liver glutathione biosynthesis and glutathione S-transferase activity in mice

Aim： To study the effects of nine synthetic clausenamide with different stereo structures on liver glutathione （GSH） biosynthesis and glutathione S-transferase （GST） activity in mice. Methods： The nine test compounds were racemic mixtures and their ennatiomers of clausenamide, neoclausenamide and ep...

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Veröffentlicht in:	Acta pharmacologica Sinica 2006-08, Vol.27 (8), p.1024-1028
Hauptverfasser:	WU, Yu‐qun, LIU, Li‐de, WEI, Hua‐ling, LIU, Geng‐tao
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals clausenamide Cytosol - metabolism Glutamate-Cysteine Ligase - metabolism glutathione Glutathione - biosynthesis Glutathione Peroxidase - metabolism Glutathione Reductase - metabolism glutathione S‐transferase Glutathione Transferase - metabolism Lactams - chemical synthesis Lactams - chemistry Lactams - pharmacology Lignans - chemical synthesis Lignans - chemistry Lignans - pharmacology Liver - cytology Male Mice Molecular Structure Stereoisomerism Structure-Activity Relationship γ‐glutamylcysteine synthetase 生物活性肝疾病药物活性谷胱甘肽
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