Apolipoprotein a polymorphism predicts lipoprotein a concentration in renal transplant recipients
Increased serum lipoprotein(a) is an independent risk factor for atherosclerosis in renal transplant recipients. Higher levels may be due to genetic factors, for example, apolipoprotein A isoforms and/or environmental states such as drugs and diets. We evaluated 75 renal transplant recipients includ...
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| Veröffentlicht in: | Transplantation proceedings 2005-09, Vol.37 (7), p.2925-2928 |
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| creator | Argani, H Ghorbanihaghjo, A Rashtchizadeh, N Rahbaninobar, M |
| description | Increased serum lipoprotein(a) is an independent risk factor for atherosclerosis in renal transplant recipients. Higher levels may be due to genetic factors, for example, apolipoprotein A isoforms and/or environmental states such as drugs and diets. We evaluated 75 renal transplant recipients including 30 men and 45 women of overall mean age of 30 +/- 7 years and transplantation duration of 57 +/- 10 months as well as 30 healthy controls for apolipoprotein A isoforms, lipoprotein(a) concentrations, serum triglycerides, serum cholesterol, serum creatinine, and serum homocysteine concentrations. High- and low-molecular-weight apolipoprotein A isoforms (>35 and |
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Higher levels may be due to genetic factors, for example, apolipoprotein A isoforms and/or environmental states such as drugs and diets. We evaluated 75 renal transplant recipients including 30 men and 45 women of overall mean age of 30 +/- 7 years and transplantation duration of 57 +/- 10 months as well as 30 healthy controls for apolipoprotein A isoforms, lipoprotein(a) concentrations, serum triglycerides, serum cholesterol, serum creatinine, and serum homocysteine concentrations. High- and low-molecular-weight apolipoprotein A isoforms (>35 and <35 kringle 4) were observed in 71% and 29% of renal transplant recipients and 83% and 17% of controls. Average lipoprotein(a) concentration ratios between high- and low-molecular-weight apolipoprotein A isoenzymes were significantly greater in renal transplant recipients than in controls. Lipoprotein A and cholesterol concentrations that did not correlate with each other were not higher among the eight renal transplant recipients with creatinine levels greater than 1.8 mg/dL. Absolute levels in renal transplant recipients with failed grafts also were not different regarding the various apolipoprotein A phenotypes. Homocysteine levels were significantly higher with high-molecular-weight apolipoprotein A isoenzymes. A relationship existed between lipoprotein(a) and triglycerides, but not cholesterol: higher triglyceride levels were associated more with high-molecular-weight isoforms of apolipoprotein A (P = .027). Lipoprotein(a) concentrations are higher in low-molecular-weight isoforms of apolipoprotein but triglyceride levels and homocysteine concentrations are higher among the high-molecular-weight isoforms of apolipoprotein A. This finding could be used as a guideline to select the most appropriate drug for different apolipoprotein A isoforms.</description><identifier>ISSN: 0041-1345</identifier><identifier>PMID: 16213263</identifier><language>eng</language><publisher>United States</publisher><subject>Adult ; Apolipoproteins A - genetics ; Cholesterol - blood ; Creatinine - blood ; Female ; Homocysteine - blood ; Humans ; Kidney Transplantation - physiology ; Lipoprotein(a) - blood ; Male ; Polymorphism, Genetic ; Protein Isoforms - genetics ; Reference Values ; Triglycerides - blood</subject><ispartof>Transplantation proceedings, 2005-09, Vol.37 (7), p.2925-2928</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/16213263$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Argani, H</creatorcontrib><creatorcontrib>Ghorbanihaghjo, A</creatorcontrib><creatorcontrib>Rashtchizadeh, N</creatorcontrib><creatorcontrib>Rahbaninobar, M</creatorcontrib><title>Apolipoprotein a polymorphism predicts lipoprotein a concentration in renal transplant recipients</title><title>Transplantation proceedings</title><addtitle>Transplant Proc</addtitle><description>Increased serum lipoprotein(a) is an independent risk factor for atherosclerosis in renal transplant recipients. Higher levels may be due to genetic factors, for example, apolipoprotein A isoforms and/or environmental states such as drugs and diets. We evaluated 75 renal transplant recipients including 30 men and 45 women of overall mean age of 30 +/- 7 years and transplantation duration of 57 +/- 10 months as well as 30 healthy controls for apolipoprotein A isoforms, lipoprotein(a) concentrations, serum triglycerides, serum cholesterol, serum creatinine, and serum homocysteine concentrations. High- and low-molecular-weight apolipoprotein A isoforms (>35 and <35 kringle 4) were observed in 71% and 29% of renal transplant recipients and 83% and 17% of controls. Average lipoprotein(a) concentration ratios between high- and low-molecular-weight apolipoprotein A isoenzymes were significantly greater in renal transplant recipients than in controls. Lipoprotein A and cholesterol concentrations that did not correlate with each other were not higher among the eight renal transplant recipients with creatinine levels greater than 1.8 mg/dL. Absolute levels in renal transplant recipients with failed grafts also were not different regarding the various apolipoprotein A phenotypes. Homocysteine levels were significantly higher with high-molecular-weight apolipoprotein A isoenzymes. A relationship existed between lipoprotein(a) and triglycerides, but not cholesterol: higher triglyceride levels were associated more with high-molecular-weight isoforms of apolipoprotein A (P = .027). Lipoprotein(a) concentrations are higher in low-molecular-weight isoforms of apolipoprotein but triglyceride levels and homocysteine concentrations are higher among the high-molecular-weight isoforms of apolipoprotein A. This finding could be used as a guideline to select the most appropriate drug for different apolipoprotein A isoforms.</description><subject>Adult</subject><subject>Apolipoproteins A - genetics</subject><subject>Cholesterol - blood</subject><subject>Creatinine - blood</subject><subject>Female</subject><subject>Homocysteine - blood</subject><subject>Humans</subject><subject>Kidney Transplantation - physiology</subject><subject>Lipoprotein(a) - blood</subject><subject>Male</subject><subject>Polymorphism, Genetic</subject><subject>Protein Isoforms - genetics</subject><subject>Reference Values</subject><subject>Triglycerides - blood</subject><issn>0041-1345</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2005</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpVkEtrAyEUhV20NGnav1BcdTfga9QsQ-gLAtlkPzjOlVpm1KpZ5N9XaLro6nI-Pg6He4PWhAjaUS76Fbov5Yu0zAS_QysqGeVM8jUyuxRnn2LKsYIP2OCWL0vM6dOXBacMk7e14P-OjcFCqNlUHwNuKEMwM24glDSbUBuwPvnmlAd068xc4PF6N-j0-nLav3eH49vHfnfoUi94R6V0yhKt-QRuJI6J3m4dbaHXghoCZmQAepKsNyCFU27kssFJaa2s0HyDnn9r28rvM5Q6LL5YmNsaiOcySC2VYnzbxKereB4XmIaU_WLyZfj7Cf8BTrVgDw</recordid><startdate>200509</startdate><enddate>200509</enddate><creator>Argani, H</creator><creator>Ghorbanihaghjo, A</creator><creator>Rashtchizadeh, N</creator><creator>Rahbaninobar, M</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope></search><sort><creationdate>200509</creationdate><title>Apolipoprotein a polymorphism predicts lipoprotein a concentration in renal transplant recipients</title><author>Argani, H ; Ghorbanihaghjo, A ; Rashtchizadeh, N ; Rahbaninobar, M</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-p543-166f7c0883defb0f245c9f1def5841a0eab2ee8d625ae64f7fb36eabd7887c483</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2005</creationdate><topic>Adult</topic><topic>Apolipoproteins A - genetics</topic><topic>Cholesterol - blood</topic><topic>Creatinine - blood</topic><topic>Female</topic><topic>Homocysteine - blood</topic><topic>Humans</topic><topic>Kidney Transplantation - physiology</topic><topic>Lipoprotein(a) - blood</topic><topic>Male</topic><topic>Polymorphism, Genetic</topic><topic>Protein Isoforms - genetics</topic><topic>Reference Values</topic><topic>Triglycerides - blood</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Argani, H</creatorcontrib><creatorcontrib>Ghorbanihaghjo, A</creatorcontrib><creatorcontrib>Rashtchizadeh, N</creatorcontrib><creatorcontrib>Rahbaninobar, M</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><jtitle>Transplantation proceedings</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Argani, H</au><au>Ghorbanihaghjo, A</au><au>Rashtchizadeh, N</au><au>Rahbaninobar, M</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Apolipoprotein a polymorphism predicts lipoprotein a concentration in renal transplant recipients</atitle><jtitle>Transplantation proceedings</jtitle><addtitle>Transplant Proc</addtitle><date>2005-09</date><risdate>2005</risdate><volume>37</volume><issue>7</issue><spage>2925</spage><epage>2928</epage><pages>2925-2928</pages><issn>0041-1345</issn><abstract>Increased serum lipoprotein(a) is an independent risk factor for atherosclerosis in renal transplant recipients. Higher levels may be due to genetic factors, for example, apolipoprotein A isoforms and/or environmental states such as drugs and diets. We evaluated 75 renal transplant recipients including 30 men and 45 women of overall mean age of 30 +/- 7 years and transplantation duration of 57 +/- 10 months as well as 30 healthy controls for apolipoprotein A isoforms, lipoprotein(a) concentrations, serum triglycerides, serum cholesterol, serum creatinine, and serum homocysteine concentrations. High- and low-molecular-weight apolipoprotein A isoforms (>35 and <35 kringle 4) were observed in 71% and 29% of renal transplant recipients and 83% and 17% of controls. Average lipoprotein(a) concentration ratios between high- and low-molecular-weight apolipoprotein A isoenzymes were significantly greater in renal transplant recipients than in controls. Lipoprotein A and cholesterol concentrations that did not correlate with each other were not higher among the eight renal transplant recipients with creatinine levels greater than 1.8 mg/dL. Absolute levels in renal transplant recipients with failed grafts also were not different regarding the various apolipoprotein A phenotypes. Homocysteine levels were significantly higher with high-molecular-weight apolipoprotein A isoenzymes. A relationship existed between lipoprotein(a) and triglycerides, but not cholesterol: higher triglyceride levels were associated more with high-molecular-weight isoforms of apolipoprotein A (P = .027). Lipoprotein(a) concentrations are higher in low-molecular-weight isoforms of apolipoprotein but triglyceride levels and homocysteine concentrations are higher among the high-molecular-weight isoforms of apolipoprotein A. This finding could be used as a guideline to select the most appropriate drug for different apolipoprotein A isoforms.</abstract><cop>United States</cop><pmid>16213263</pmid><tpages>4</tpages></addata></record> |
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| ispartof | Transplantation proceedings, 2005-09, Vol.37 (7), p.2925-2928 |
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| language | eng |
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| source | MEDLINE; ScienceDirect Journals (5 years ago - present) |
| subjects | Adult Apolipoproteins A - genetics Cholesterol - blood Creatinine - blood Female Homocysteine - blood Humans Kidney Transplantation - physiology Lipoprotein(a) - blood Male Polymorphism, Genetic Protein Isoforms - genetics Reference Values Triglycerides - blood |
| title | Apolipoprotein a polymorphism predicts lipoprotein a concentration in renal transplant recipients |
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