Formulation study and drug release mechanism of a new theophylline sustained-release preparation
Two matrix theophylline tablets with different release mechanisms were compared. Tablet A was a swelling/disintegration-type wax matrix made of hydrophobic wax granules, consisting of stearic acid, hydrogenated oil and glycerol esters of fatty acids, and hydrophilic polymer granules composed primari...
Gespeichert in:
| Veröffentlicht in: | International journal of pharmaceutics 2005-11, Vol.304 (1), p.91-101 |
|---|---|
| Hauptverfasser: | , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 101 |
|---|---|
| container_issue | 1 |
| container_start_page | 91 |
| container_title | International journal of pharmaceutics |
| container_volume | 304 |
| creator | Hayashi, Tetsuo Kanbe, Hideyoshi Okada, Minoru Suzuki, Makoto Ikeda, Yasuo Onuki, Yoichi Kaneko, Tetsuo Sonobe, Takashi |
| description | Two matrix theophylline tablets with different release mechanisms were compared. Tablet A was a swelling/disintegration-type wax matrix made of hydrophobic wax granules, consisting of stearic acid, hydrogenated oil and glycerol esters of fatty acids, and hydrophilic polymer granules composed primarily of hydroxypropyl methylcellulose (HPMC). We named Tablet A the cluster tablet. Tablet B was a gel matrix made of hydrophobic ethylcellulose granules, consisting of ethylcellulose and hydrogenated oil, and hydrophilic polymer granules consisting of HPMC and hydroxylpropylmethylcellulose acetate succinate (HPMCAS).
The formulations were screened in vitro according to their dissolution characteristics. The drug release from each preparation was analyzed using release kinetics theories. In Tablet A, the value of the exponent(
n) representing the apparent diffusion mechanism determined from the Korsmeyer–Peppas model equation was about 0.6 and was unlikely to be affected by the rotation speed. In Tablet B, the value of the exponent(
n) by the Korsmeyer–Peppas model equation changed with the paddle rotation speed. These results suggested that the drug release mechanism of Tablet B is greatly affected by the extent of physical force in the gastrointestinal tract. |
| doi_str_mv | 10.1016/j.ijpharm.2005.07.022 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_68676795</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S0378517305005090</els_id><sourcerecordid>68676795</sourcerecordid><originalsourceid>FETCH-LOGICAL-c393t-6a792716bb747a784ea568f52cb751f1103a424a97f5029a201a9cc4447b17253</originalsourceid><addsrcrecordid>eNqFkE1v1DAQhi0EokvhJ4B8obek_oonOSFUUYpUqRc4m4kzYb3KF3ZStP-ebDeoR04zh-d9Z_Qw9l6KXApprw95OEx7jH2uhChyAblQ6gXbyRJ0pg3Yl2wnNJRZIUFfsDcpHYQQVkn9ml1IKwujhdqxn7dj7JcO5zAOPM1Lc-Q4NLyJyy8eqSNMxHvyexxC6vnYcuQD_eHznsZpf-y6MBBPS5pxXZrsX2KKNGF8Kn3LXrXYJXq3zUv24_bL95u77P7h67ebz_eZ15WeM4tQKZC2rsEAQmkIC1u2hfI1FLKVUmg0ymAFbSFUhUpIrLw3xkAtQRX6kl2de6c4_l4oza4PyVPX4UDjkpwtLVioTmBxBn0cU4rUuimGHuPRSeFOat3BbWrdSa0T4Fa1a-7DdmCpe2qeU5vLFfi4AZg8dm3EwYf0zIHS0pTVyn06c7TqeAwUXfKBBk9NiORn14zhP6_8BWKKmnE</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>68676795</pqid></control><display><type>article</type><title>Formulation study and drug release mechanism of a new theophylline sustained-release preparation</title><source>MEDLINE</source><source>Elsevier ScienceDirect Journals Complete</source><creator>Hayashi, Tetsuo ; Kanbe, Hideyoshi ; Okada, Minoru ; Suzuki, Makoto ; Ikeda, Yasuo ; Onuki, Yoichi ; Kaneko, Tetsuo ; Sonobe, Takashi</creator><creatorcontrib>Hayashi, Tetsuo ; Kanbe, Hideyoshi ; Okada, Minoru ; Suzuki, Makoto ; Ikeda, Yasuo ; Onuki, Yoichi ; Kaneko, Tetsuo ; Sonobe, Takashi</creatorcontrib><description>Two matrix theophylline tablets with different release mechanisms were compared. Tablet A was a swelling/disintegration-type wax matrix made of hydrophobic wax granules, consisting of stearic acid, hydrogenated oil and glycerol esters of fatty acids, and hydrophilic polymer granules composed primarily of hydroxypropyl methylcellulose (HPMC). We named Tablet A the cluster tablet. Tablet B was a gel matrix made of hydrophobic ethylcellulose granules, consisting of ethylcellulose and hydrogenated oil, and hydrophilic polymer granules consisting of HPMC and hydroxylpropylmethylcellulose acetate succinate (HPMCAS).
The formulations were screened in vitro according to their dissolution characteristics. The drug release from each preparation was analyzed using release kinetics theories. In Tablet A, the value of the exponent(
n) representing the apparent diffusion mechanism determined from the Korsmeyer–Peppas model equation was about 0.6 and was unlikely to be affected by the rotation speed. In Tablet B, the value of the exponent(
n) by the Korsmeyer–Peppas model equation changed with the paddle rotation speed. These results suggested that the drug release mechanism of Tablet B is greatly affected by the extent of physical force in the gastrointestinal tract.</description><identifier>ISSN: 0378-5173</identifier><identifier>EISSN: 1873-3476</identifier><identifier>DOI: 10.1016/j.ijpharm.2005.07.022</identifier><identifier>PMID: 16154302</identifier><identifier>CODEN: IJPHDE</identifier><language>eng</language><publisher>Amsterdam: Elsevier B.V</publisher><subject>Biological and medical sciences ; Delayed-Action Preparations ; Drug Compounding ; Excipients - chemistry ; General pharmacology ; Hydrophilic polymer ; Hydrophobic wax ; Kinetics ; Matrix tablet ; Medical sciences ; Pharmaceutical technology. Pharmaceutical industry ; Pharmacology. Drug treatments ; Polymers - chemistry ; Release mechanism ; Solubility ; Sustained-release ; Tablets ; Theophylline ; Theophylline - chemistry</subject><ispartof>International journal of pharmaceutics, 2005-11, Vol.304 (1), p.91-101</ispartof><rights>2005 Elsevier B.V.</rights><rights>2005 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c393t-6a792716bb747a784ea568f52cb751f1103a424a97f5029a201a9cc4447b17253</citedby><cites>FETCH-LOGICAL-c393t-6a792716bb747a784ea568f52cb751f1103a424a97f5029a201a9cc4447b17253</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0378517305005090$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=17231489$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/16154302$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Hayashi, Tetsuo</creatorcontrib><creatorcontrib>Kanbe, Hideyoshi</creatorcontrib><creatorcontrib>Okada, Minoru</creatorcontrib><creatorcontrib>Suzuki, Makoto</creatorcontrib><creatorcontrib>Ikeda, Yasuo</creatorcontrib><creatorcontrib>Onuki, Yoichi</creatorcontrib><creatorcontrib>Kaneko, Tetsuo</creatorcontrib><creatorcontrib>Sonobe, Takashi</creatorcontrib><title>Formulation study and drug release mechanism of a new theophylline sustained-release preparation</title><title>International journal of pharmaceutics</title><addtitle>Int J Pharm</addtitle><description>Two matrix theophylline tablets with different release mechanisms were compared. Tablet A was a swelling/disintegration-type wax matrix made of hydrophobic wax granules, consisting of stearic acid, hydrogenated oil and glycerol esters of fatty acids, and hydrophilic polymer granules composed primarily of hydroxypropyl methylcellulose (HPMC). We named Tablet A the cluster tablet. Tablet B was a gel matrix made of hydrophobic ethylcellulose granules, consisting of ethylcellulose and hydrogenated oil, and hydrophilic polymer granules consisting of HPMC and hydroxylpropylmethylcellulose acetate succinate (HPMCAS).
The formulations were screened in vitro according to their dissolution characteristics. The drug release from each preparation was analyzed using release kinetics theories. In Tablet A, the value of the exponent(
n) representing the apparent diffusion mechanism determined from the Korsmeyer–Peppas model equation was about 0.6 and was unlikely to be affected by the rotation speed. In Tablet B, the value of the exponent(
n) by the Korsmeyer–Peppas model equation changed with the paddle rotation speed. These results suggested that the drug release mechanism of Tablet B is greatly affected by the extent of physical force in the gastrointestinal tract.</description><subject>Biological and medical sciences</subject><subject>Delayed-Action Preparations</subject><subject>Drug Compounding</subject><subject>Excipients - chemistry</subject><subject>General pharmacology</subject><subject>Hydrophilic polymer</subject><subject>Hydrophobic wax</subject><subject>Kinetics</subject><subject>Matrix tablet</subject><subject>Medical sciences</subject><subject>Pharmaceutical technology. Pharmaceutical industry</subject><subject>Pharmacology. Drug treatments</subject><subject>Polymers - chemistry</subject><subject>Release mechanism</subject><subject>Solubility</subject><subject>Sustained-release</subject><subject>Tablets</subject><subject>Theophylline</subject><subject>Theophylline - chemistry</subject><issn>0378-5173</issn><issn>1873-3476</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2005</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkE1v1DAQhi0EokvhJ4B8obek_oonOSFUUYpUqRc4m4kzYb3KF3ZStP-ebDeoR04zh-d9Z_Qw9l6KXApprw95OEx7jH2uhChyAblQ6gXbyRJ0pg3Yl2wnNJRZIUFfsDcpHYQQVkn9ml1IKwujhdqxn7dj7JcO5zAOPM1Lc-Q4NLyJyy8eqSNMxHvyexxC6vnYcuQD_eHznsZpf-y6MBBPS5pxXZrsX2KKNGF8Kn3LXrXYJXq3zUv24_bL95u77P7h67ebz_eZ15WeM4tQKZC2rsEAQmkIC1u2hfI1FLKVUmg0ymAFbSFUhUpIrLw3xkAtQRX6kl2de6c4_l4oza4PyVPX4UDjkpwtLVioTmBxBn0cU4rUuimGHuPRSeFOat3BbWrdSa0T4Fa1a-7DdmCpe2qeU5vLFfi4AZg8dm3EwYf0zIHS0pTVyn06c7TqeAwUXfKBBk9NiORn14zhP6_8BWKKmnE</recordid><startdate>20051104</startdate><enddate>20051104</enddate><creator>Hayashi, Tetsuo</creator><creator>Kanbe, Hideyoshi</creator><creator>Okada, Minoru</creator><creator>Suzuki, Makoto</creator><creator>Ikeda, Yasuo</creator><creator>Onuki, Yoichi</creator><creator>Kaneko, Tetsuo</creator><creator>Sonobe, Takashi</creator><general>Elsevier B.V</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20051104</creationdate><title>Formulation study and drug release mechanism of a new theophylline sustained-release preparation</title><author>Hayashi, Tetsuo ; Kanbe, Hideyoshi ; Okada, Minoru ; Suzuki, Makoto ; Ikeda, Yasuo ; Onuki, Yoichi ; Kaneko, Tetsuo ; Sonobe, Takashi</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c393t-6a792716bb747a784ea568f52cb751f1103a424a97f5029a201a9cc4447b17253</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2005</creationdate><topic>Biological and medical sciences</topic><topic>Delayed-Action Preparations</topic><topic>Drug Compounding</topic><topic>Excipients - chemistry</topic><topic>General pharmacology</topic><topic>Hydrophilic polymer</topic><topic>Hydrophobic wax</topic><topic>Kinetics</topic><topic>Matrix tablet</topic><topic>Medical sciences</topic><topic>Pharmaceutical technology. Pharmaceutical industry</topic><topic>Pharmacology. Drug treatments</topic><topic>Polymers - chemistry</topic><topic>Release mechanism</topic><topic>Solubility</topic><topic>Sustained-release</topic><topic>Tablets</topic><topic>Theophylline</topic><topic>Theophylline - chemistry</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Hayashi, Tetsuo</creatorcontrib><creatorcontrib>Kanbe, Hideyoshi</creatorcontrib><creatorcontrib>Okada, Minoru</creatorcontrib><creatorcontrib>Suzuki, Makoto</creatorcontrib><creatorcontrib>Ikeda, Yasuo</creatorcontrib><creatorcontrib>Onuki, Yoichi</creatorcontrib><creatorcontrib>Kaneko, Tetsuo</creatorcontrib><creatorcontrib>Sonobe, Takashi</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>International journal of pharmaceutics</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Hayashi, Tetsuo</au><au>Kanbe, Hideyoshi</au><au>Okada, Minoru</au><au>Suzuki, Makoto</au><au>Ikeda, Yasuo</au><au>Onuki, Yoichi</au><au>Kaneko, Tetsuo</au><au>Sonobe, Takashi</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Formulation study and drug release mechanism of a new theophylline sustained-release preparation</atitle><jtitle>International journal of pharmaceutics</jtitle><addtitle>Int J Pharm</addtitle><date>2005-11-04</date><risdate>2005</risdate><volume>304</volume><issue>1</issue><spage>91</spage><epage>101</epage><pages>91-101</pages><issn>0378-5173</issn><eissn>1873-3476</eissn><coden>IJPHDE</coden><abstract>Two matrix theophylline tablets with different release mechanisms were compared. Tablet A was a swelling/disintegration-type wax matrix made of hydrophobic wax granules, consisting of stearic acid, hydrogenated oil and glycerol esters of fatty acids, and hydrophilic polymer granules composed primarily of hydroxypropyl methylcellulose (HPMC). We named Tablet A the cluster tablet. Tablet B was a gel matrix made of hydrophobic ethylcellulose granules, consisting of ethylcellulose and hydrogenated oil, and hydrophilic polymer granules consisting of HPMC and hydroxylpropylmethylcellulose acetate succinate (HPMCAS).
The formulations were screened in vitro according to their dissolution characteristics. The drug release from each preparation was analyzed using release kinetics theories. In Tablet A, the value of the exponent(
n) representing the apparent diffusion mechanism determined from the Korsmeyer–Peppas model equation was about 0.6 and was unlikely to be affected by the rotation speed. In Tablet B, the value of the exponent(
n) by the Korsmeyer–Peppas model equation changed with the paddle rotation speed. These results suggested that the drug release mechanism of Tablet B is greatly affected by the extent of physical force in the gastrointestinal tract.</abstract><cop>Amsterdam</cop><pub>Elsevier B.V</pub><pmid>16154302</pmid><doi>10.1016/j.ijpharm.2005.07.022</doi><tpages>11</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0378-5173 |
| ispartof | International journal of pharmaceutics, 2005-11, Vol.304 (1), p.91-101 |
| issn | 0378-5173 1873-3476 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_68676795 |
| source | MEDLINE; Elsevier ScienceDirect Journals Complete |
| subjects | Biological and medical sciences Delayed-Action Preparations Drug Compounding Excipients - chemistry General pharmacology Hydrophilic polymer Hydrophobic wax Kinetics Matrix tablet Medical sciences Pharmaceutical technology. Pharmaceutical industry Pharmacology. Drug treatments Polymers - chemistry Release mechanism Solubility Sustained-release Tablets Theophylline Theophylline - chemistry |
| title | Formulation study and drug release mechanism of a new theophylline sustained-release preparation |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-12T17%3A35%3A35IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Formulation%20study%20and%20drug%20release%20mechanism%20of%20a%20new%20theophylline%20sustained-release%20preparation&rft.jtitle=International%20journal%20of%20pharmaceutics&rft.au=Hayashi,%20Tetsuo&rft.date=2005-11-04&rft.volume=304&rft.issue=1&rft.spage=91&rft.epage=101&rft.pages=91-101&rft.issn=0378-5173&rft.eissn=1873-3476&rft.coden=IJPHDE&rft_id=info:doi/10.1016/j.ijpharm.2005.07.022&rft_dat=%3Cproquest_cross%3E68676795%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=68676795&rft_id=info:pmid/16154302&rft_els_id=S0378517305005090&rfr_iscdi=true |