Quantitative analysis of HIV-1 variants with the K103N resistance mutation after single-dose nevirapine in women with HIV-1 subtypes A, C, and D

We used a sensitive point mutation assay, LigAmp, to detect and quantify K103N-containing variants in African women who received single-dose nevirapine (NVP) to prevent mother-to-child HIV-1 transmission. Plasma for testing was collected 6 to 8 weeks postpartum from 301 women (144 subtype A, 63 subt...

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Veröffentlicht in:	Journal of acquired immune deficiency syndromes (1999) 2006-08, Vol.42 (5), p.610-613
Hauptverfasser:	FLYS, Tamara S, SHU CHEN, KUMWENDA, Newton, TAHA, Taha E, JACKSON, J. Brooks, ESHLEMAN, Susan H, JONES, Dana C, HOOVER, Donald R, CHURCH, Jessica D, FISCUS, Susan A, MWATHA, Anthony, GUAY, Laura A, MMIRO, Francis, MUSOKE, Philippa
Format:	Artikel
Sprache:	eng
Schlagworte:	AIDS/HIV Amino Acid Substitution Anti-HIV Agents - pharmacology Anti-HIV Agents - therapeutic use Biological and medical sciences Black people Disease transmission Drug Resistance, Viral - genetics Drug therapy Female Fundamental and applied biological sciences. Psychology Genotype HIV HIV Infections - drug therapy HIV Infections - transmission HIV Infections - virology HIV-1 - classification HIV-1 - drug effects HIV-1 - genetics Human immunodeficiency virus Human immunodeficiency virus 1 Human viral diseases Humans Infectious Disease Transmission, Vertical - prevention & control Infectious diseases Malawi Medical sciences Microbiology Miscellaneous Mutation, Missense Nevirapine - pharmacology Nevirapine - therapeutic use Point Mutation Pregnancy Pregnancy Complications, Infectious - drug therapy Pregnancy Complications, Infectious - virology Statistics as Topic Uganda Viral diseases Virology Women
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