Monomorphous Angiocentric Glioma: A Distinctive Epileptogenic Neoplasm With Features of Infiltrating Astrocytoma and Ependymoma
We present 8 examples of a neoplasm with features of both astrocytoma and ependymoma that may represent a distinct clinicopathologic entity. The cerebral hemispheric tumors occurred in patients that were 3, 4, 12, 14, 15, 26, 30, and 37 years of age. All presented with seizures that, with the except...
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creator | Wang, Min Tihan, Tarik Rojiani, Amyn M Bodhireddy, Surender R Prayson, Richard A Iacuone, John J Alles, Ajit J Donahue, David J Hessler, Richard B Kim, Jung H Haas, Mark Rosenblum, Marc K Burger, Peter C |
description | We present 8 examples of a neoplasm with features of both astrocytoma and ependymoma that may represent a distinct clinicopathologic entity. The cerebral hemispheric tumors occurred in patients that were 3, 4, 12, 14, 15, 26, 30, and 37 years of age. All presented with seizures that, with the exception of 2, began in childhood. Magnetic resonance imaging studies showed ill-defined, T2-hyperintense, generally noncontrast-enhancing lesions that, although centered on the cortex or amygdala, extended into the underlying white matter for a short distance. Histologically, the variably infiltrative tumors were distinctively angiocentric with well-developed perivascular pseudorosettes in some cases. Longitudinal and/or circumferential orientations of perivascular cells were common also. The cells were uniform in their cytologic features from case to case and were bipolar in all but one case. A glial nature was inferred from immunoreactivity for GFAP, and ependymal differentiation was suggested by positivity for EMA in three cases and ultrastructural features in one. Overall, the tumors were biologically indolent except for one that recurred and ultimately proved fatal. |
doi_str_mv | 10.1097/01.jnen.0000182981.02355.10 |
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The cerebral hemispheric tumors occurred in patients that were 3, 4, 12, 14, 15, 26, 30, and 37 years of age. All presented with seizures that, with the exception of 2, began in childhood. Magnetic resonance imaging studies showed ill-defined, T2-hyperintense, generally noncontrast-enhancing lesions that, although centered on the cortex or amygdala, extended into the underlying white matter for a short distance. Histologically, the variably infiltrative tumors were distinctively angiocentric with well-developed perivascular pseudorosettes in some cases. Longitudinal and/or circumferential orientations of perivascular cells were common also. The cells were uniform in their cytologic features from case to case and were bipolar in all but one case. A glial nature was inferred from immunoreactivity for GFAP, and ependymal differentiation was suggested by positivity for EMA in three cases and ultrastructural features in one. Overall, the tumors were biologically indolent except for one that recurred and ultimately proved fatal.</description><identifier>ISSN: 0022-3069</identifier><identifier>EISSN: 1554-6578</identifier><identifier>DOI: 10.1097/01.jnen.0000182981.02355.10</identifier><identifier>PMID: 16215459</identifier><identifier>CODEN: JNENAD</identifier><language>eng</language><publisher>Hagerstown, MD: American Association of Neuropathologists, Inc</publisher><subject>Adolescent ; Adult ; Astrocytoma - pathology ; Biological and medical sciences ; Brain Neoplasms - complications ; Brain Neoplasms - diagnosis ; Brain Neoplasms - metabolism ; Brain Neoplasms - pathology ; Child ; Child, Preschool ; Ependymoma - pathology ; Epilepsy - etiology ; Female ; Female genital diseases ; Glial Fibrillary Acidic Protein - metabolism ; Glioma - complications ; Glioma - diagnosis ; Glioma - metabolism ; Glioma - pathology ; Gynecology. Andrology. Obstetrics ; Humans ; Immunohistochemistry ; Magnetic Resonance Imaging ; Male ; Medical sciences ; Microscopy, Electron ; Mucin-1 - metabolism ; Neurology ; Tumors ; Tumors of the nervous system. Phacomatoses</subject><ispartof>Journal of neuropathology and experimental neurology, 2005-10, Vol.64 (10), p.875-881</ispartof><rights>2005 American Association of Neuropathologists, Inc</rights><rights>2005 INIST-CNRS</rights><rights>Copyright American Association of Neuropathologists, Inc. Oct 2005</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4526-e0b982ac22730d4d6df2fc2cb69cbb5d6785baa420d207829272e3387afb7d993</citedby><cites>FETCH-LOGICAL-c4526-e0b982ac22730d4d6df2fc2cb69cbb5d6785baa420d207829272e3387afb7d993</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=17217217$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/16215459$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Wang, Min</creatorcontrib><creatorcontrib>Tihan, Tarik</creatorcontrib><creatorcontrib>Rojiani, Amyn M</creatorcontrib><creatorcontrib>Bodhireddy, Surender R</creatorcontrib><creatorcontrib>Prayson, Richard A</creatorcontrib><creatorcontrib>Iacuone, John J</creatorcontrib><creatorcontrib>Alles, Ajit J</creatorcontrib><creatorcontrib>Donahue, David J</creatorcontrib><creatorcontrib>Hessler, Richard B</creatorcontrib><creatorcontrib>Kim, Jung H</creatorcontrib><creatorcontrib>Haas, Mark</creatorcontrib><creatorcontrib>Rosenblum, Marc K</creatorcontrib><creatorcontrib>Burger, Peter C</creatorcontrib><title>Monomorphous Angiocentric Glioma: A Distinctive Epileptogenic Neoplasm With Features of Infiltrating Astrocytoma and Ependymoma</title><title>Journal of neuropathology and experimental neurology</title><addtitle>J Neuropathol Exp Neurol</addtitle><description>We present 8 examples of a neoplasm with features of both astrocytoma and ependymoma that may represent a distinct clinicopathologic entity. The cerebral hemispheric tumors occurred in patients that were 3, 4, 12, 14, 15, 26, 30, and 37 years of age. All presented with seizures that, with the exception of 2, began in childhood. Magnetic resonance imaging studies showed ill-defined, T2-hyperintense, generally noncontrast-enhancing lesions that, although centered on the cortex or amygdala, extended into the underlying white matter for a short distance. Histologically, the variably infiltrative tumors were distinctively angiocentric with well-developed perivascular pseudorosettes in some cases. Longitudinal and/or circumferential orientations of perivascular cells were common also. The cells were uniform in their cytologic features from case to case and were bipolar in all but one case. A glial nature was inferred from immunoreactivity for GFAP, and ependymal differentiation was suggested by positivity for EMA in three cases and ultrastructural features in one. Overall, the tumors were biologically indolent except for one that recurred and ultimately proved fatal.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Astrocytoma - pathology</subject><subject>Biological and medical sciences</subject><subject>Brain Neoplasms - complications</subject><subject>Brain Neoplasms - diagnosis</subject><subject>Brain Neoplasms - metabolism</subject><subject>Brain Neoplasms - pathology</subject><subject>Child</subject><subject>Child, Preschool</subject><subject>Ependymoma - pathology</subject><subject>Epilepsy - etiology</subject><subject>Female</subject><subject>Female genital diseases</subject><subject>Glial Fibrillary Acidic Protein - metabolism</subject><subject>Glioma - complications</subject><subject>Glioma - diagnosis</subject><subject>Glioma - metabolism</subject><subject>Glioma - pathology</subject><subject>Gynecology. Andrology. Obstetrics</subject><subject>Humans</subject><subject>Immunohistochemistry</subject><subject>Magnetic Resonance Imaging</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Microscopy, Electron</subject><subject>Mucin-1 - metabolism</subject><subject>Neurology</subject><subject>Tumors</subject><subject>Tumors of the nervous system. Phacomatoses</subject><issn>0022-3069</issn><issn>1554-6578</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2005</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNqFkU2PFCEQhjtG446rf8EQjd56BJqPRk-TdXfdZNWLxiOhaXqGkYYWaDdz8q_LfCSTeJEQKpV63qoUb1W9RnCJoODvIFpuvfFLWA5qsWjREuKG0lJ9VC0QpaRmlLePqwWEGNcNZOKiepbStvACCvK0ukAMI0qoWFR_PgcfxhCnTZgTWPm1Ddr4HK0Gt86GUb0HK_DRpmy9zva3AdeTdWbKYW18Yb6YMDmVRvDD5g24MSrP0SQQBnDnB-tyVEW4BquUY9C7XPoB5fvSxPh-N5b0efVkUC6ZF6d4WX2_uf529am-_3p7d7W6rzWhmNUGdqLFSmPMG9iTnvUDHjTWHRO662jPeEs7pQiGPYa8fArm2DRNy9XQ8V6I5rJ6e-w7xfBrNinL0SZtnFPelM0laxmnmMD_gkgQxCmlBXz1D7gNc_RlCYmx4AySdj_2wxHSMaQUzSCnaEcVdxJBuXdTQiT3bsqzm_LgZqkW9cvTiLkbTX_WnuwrwJsToJJWbojKa5vOHMeHWzhy5B6Cyyamn25-MFFujHJ5cxhNIcc1LhHts3r_sOYvnKC6SQ</recordid><startdate>200510</startdate><enddate>200510</enddate><creator>Wang, Min</creator><creator>Tihan, Tarik</creator><creator>Rojiani, Amyn M</creator><creator>Bodhireddy, Surender R</creator><creator>Prayson, Richard A</creator><creator>Iacuone, John J</creator><creator>Alles, Ajit J</creator><creator>Donahue, David J</creator><creator>Hessler, Richard B</creator><creator>Kim, Jung H</creator><creator>Haas, Mark</creator><creator>Rosenblum, Marc K</creator><creator>Burger, Peter C</creator><general>American Association of Neuropathologists, Inc</general><general>Lippincott Williams & Wilkins</general><general>Oxford University Press</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>88G</scope><scope>88I</scope><scope>8AF</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>M2P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>Q9U</scope><scope>S0X</scope><scope>7TK</scope><scope>7X8</scope></search><sort><creationdate>200510</creationdate><title>Monomorphous Angiocentric Glioma: A Distinctive Epileptogenic Neoplasm With Features of Infiltrating Astrocytoma and Ependymoma</title><author>Wang, Min ; Tihan, Tarik ; Rojiani, Amyn M ; Bodhireddy, Surender R ; Prayson, Richard A ; Iacuone, John J ; Alles, Ajit J ; Donahue, David J ; Hessler, Richard B ; Kim, Jung H ; Haas, Mark ; Rosenblum, Marc K ; Burger, Peter C</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4526-e0b982ac22730d4d6df2fc2cb69cbb5d6785baa420d207829272e3387afb7d993</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2005</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Astrocytoma - pathology</topic><topic>Biological and medical sciences</topic><topic>Brain Neoplasms - complications</topic><topic>Brain Neoplasms - diagnosis</topic><topic>Brain Neoplasms - metabolism</topic><topic>Brain Neoplasms - pathology</topic><topic>Child</topic><topic>Child, Preschool</topic><topic>Ependymoma - pathology</topic><topic>Epilepsy - etiology</topic><topic>Female</topic><topic>Female genital diseases</topic><topic>Glial Fibrillary Acidic Protein - metabolism</topic><topic>Glioma - complications</topic><topic>Glioma - diagnosis</topic><topic>Glioma - metabolism</topic><topic>Glioma - pathology</topic><topic>Gynecology. Andrology. Obstetrics</topic><topic>Humans</topic><topic>Immunohistochemistry</topic><topic>Magnetic Resonance Imaging</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Microscopy, Electron</topic><topic>Mucin-1 - metabolism</topic><topic>Neurology</topic><topic>Tumors</topic><topic>Tumors of the nervous system. Phacomatoses</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Wang, Min</creatorcontrib><creatorcontrib>Tihan, Tarik</creatorcontrib><creatorcontrib>Rojiani, Amyn M</creatorcontrib><creatorcontrib>Bodhireddy, Surender R</creatorcontrib><creatorcontrib>Prayson, Richard A</creatorcontrib><creatorcontrib>Iacuone, John J</creatorcontrib><creatorcontrib>Alles, Ajit J</creatorcontrib><creatorcontrib>Donahue, David J</creatorcontrib><creatorcontrib>Hessler, Richard B</creatorcontrib><creatorcontrib>Kim, Jung H</creatorcontrib><creatorcontrib>Haas, Mark</creatorcontrib><creatorcontrib>Rosenblum, Marc K</creatorcontrib><creatorcontrib>Burger, Peter C</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Psychology Database (Alumni)</collection><collection>Science Database (Alumni Edition)</collection><collection>STEM Database</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Science Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest Central Basic</collection><collection>SIRS Editorial</collection><collection>Neurosciences Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of neuropathology and experimental neurology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Wang, Min</au><au>Tihan, Tarik</au><au>Rojiani, Amyn M</au><au>Bodhireddy, Surender R</au><au>Prayson, Richard A</au><au>Iacuone, John J</au><au>Alles, Ajit J</au><au>Donahue, David J</au><au>Hessler, Richard B</au><au>Kim, Jung H</au><au>Haas, Mark</au><au>Rosenblum, Marc K</au><au>Burger, Peter C</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Monomorphous Angiocentric Glioma: A Distinctive Epileptogenic Neoplasm With Features of Infiltrating Astrocytoma and Ependymoma</atitle><jtitle>Journal of neuropathology and experimental neurology</jtitle><addtitle>J Neuropathol Exp Neurol</addtitle><date>2005-10</date><risdate>2005</risdate><volume>64</volume><issue>10</issue><spage>875</spage><epage>881</epage><pages>875-881</pages><issn>0022-3069</issn><eissn>1554-6578</eissn><coden>JNENAD</coden><abstract>We present 8 examples of a neoplasm with features of both astrocytoma and ependymoma that may represent a distinct clinicopathologic entity. The cerebral hemispheric tumors occurred in patients that were 3, 4, 12, 14, 15, 26, 30, and 37 years of age. All presented with seizures that, with the exception of 2, began in childhood. Magnetic resonance imaging studies showed ill-defined, T2-hyperintense, generally noncontrast-enhancing lesions that, although centered on the cortex or amygdala, extended into the underlying white matter for a short distance. Histologically, the variably infiltrative tumors were distinctively angiocentric with well-developed perivascular pseudorosettes in some cases. Longitudinal and/or circumferential orientations of perivascular cells were common also. The cells were uniform in their cytologic features from case to case and were bipolar in all but one case. A glial nature was inferred from immunoreactivity for GFAP, and ependymal differentiation was suggested by positivity for EMA in three cases and ultrastructural features in one. Overall, the tumors were biologically indolent except for one that recurred and ultimately proved fatal.</abstract><cop>Hagerstown, MD</cop><pub>American Association of Neuropathologists, Inc</pub><pmid>16215459</pmid><doi>10.1097/01.jnen.0000182981.02355.10</doi><tpages>7</tpages></addata></record> |
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subjects | Adolescent Adult Astrocytoma - pathology Biological and medical sciences Brain Neoplasms - complications Brain Neoplasms - diagnosis Brain Neoplasms - metabolism Brain Neoplasms - pathology Child Child, Preschool Ependymoma - pathology Epilepsy - etiology Female Female genital diseases Glial Fibrillary Acidic Protein - metabolism Glioma - complications Glioma - diagnosis Glioma - metabolism Glioma - pathology Gynecology. Andrology. Obstetrics Humans Immunohistochemistry Magnetic Resonance Imaging Male Medical sciences Microscopy, Electron Mucin-1 - metabolism Neurology Tumors Tumors of the nervous system. Phacomatoses |
title | Monomorphous Angiocentric Glioma: A Distinctive Epileptogenic Neoplasm With Features of Infiltrating Astrocytoma and Ependymoma |
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