Polyozellin inhibits nitric oxide production by down-regulating LPS-induced activity of NF-kappaB and SAPK/JNK in RAW 264.7 cells

Polyozellin, isolated from Polyozellus multiplex (Thelephoraceae), was investigated for its anti-inflammatory activity in the murine macrophage cell line RAW 264.7. Polyozellin inhibited both lipopolysaccharide (LPS)-induced nitric oxide (NO) production and inducible nitric oxide synthase (iNOS) gen...

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Veröffentlicht in:	Planta medica 2006-07, Vol.72 (9), p.857-859
Hauptverfasser:	Jin, X.Y, Lee, S.H, Kim, J.Y, Zhao, Y.Z, Park, E.J, Lee, B.S, Nan, J.X, Song, K.S, Ko, G, Sohn, D.H
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals anti-inflammatory activity Anti-Inflammatory Agents - chemistry Anti-Inflammatory Agents - isolation & purification Anti-Inflammatory Agents - pharmacology Basidiomycota Basidiomycota - chemistry biosynthesis Cell Line cultured cells Down-Regulation enzyme inhibition Extracellular Signal-Regulated MAP Kinases - genetics Extracellular Signal-Regulated MAP Kinases - metabolism furans Furans - chemistry Furans - isolation & purification Furans - pharmacology JNK Mitogen-Activated Protein Kinases - antagonists & inhibitors JNK Mitogen-Activated Protein Kinases - genetics JNK Mitogen-Activated Protein Kinases - metabolism Lipopolysaccharides - antagonists & inhibitors Lipopolysaccharides - metabolism Mice mitogen-activated protein kinases NF-kappa B - antagonists & inhibitors NF-kappa B - genetics NF-kappa B - metabolism NF-kappaB factor nitric oxide Nitric Oxide - biosynthesis nitric oxide synthase Nitric Oxide Synthase Type II - antagonists & inhibitors Nitric Oxide Synthase Type II - genetics Nitric Oxide Synthase Type II - metabolism p38 Mitogen-Activated Protein Kinases - genetics p38 Mitogen-Activated Protein Kinases - metabolism Polyozellus multiplex polyzellin signal transduction transcription factors
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