Involvement of nuclear factor-kappaB in the inhibition of pro-inflammatory mediators by pinosylvin

Nuclear factor-kappaB (NF-kappaB) is a critical transcription factor for maximal expression of many of the cytokines that are involved in the pathogenesis of inflammatory diseases. In this study, we found that pinosylvin, a natural stilbenoid that is a component of the pine leaf (Pinus densiflora),...

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Veröffentlicht in:	Planta medica 2006-07, Vol.72 (9), p.801-806
Hauptverfasser:	Lee, J, Jung, E, Lim, J, Hur, S, Kim, S.S, Lim, S, Hyun, C.G, Kim, Y.S, Park, D
Format:	Artikel
Sprache:	eng
Schlagworte:	Anti-Inflammatory Agents - pharmacology Binding Sites Cell Line cultured cells Cyclooxygenase 2 - genetics Cyclooxygenase 2 Inhibitors - pharmacology Cytokines - metabolism Gene Expression Regulation - drug effects Genes, Reporter Humans I-kappa B Proteins - metabolism inflammation interleukin-8 Interleukin-8 - antagonists & inhibitors Interleukin-8 - genetics Lipopolysaccharides - antagonists & inhibitors Luciferases - analysis NF-kappa B - antagonists & inhibitors NF-kappa B - metabolism NF-kappa B - physiology nuclear factor kappa-B Phosphorylation pinosylvin Pinus - chemistry Pinus densiflora Promoter Regions, Genetic prostaglandin synthase signal transduction Signal Transduction - drug effects stilbenes Stilbenes - chemistry Stilbenes - pharmacology transcription factors tumor necrosis factor-alpha Tumor Necrosis Factor-alpha - antagonists & inhibitors Tumor Necrosis Factor-alpha - genetics
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