Distinct profiles of Sjögren's syndrome patients with ectopic salivary gland germinal centers revealed by serum cytokines and BAFF

The formation of ectopic germinal centers (GC) has been described in Sjögren's syndrome (SS), although little is known about the molecular basis of this phenomenon. These structures are a focus of in situ autoantibody production and have been hypothesized to be involved in lymphomagenesis in SS...

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Veröffentlicht in:	Clinical Immunology 2005-11, Vol.117 (2), p.168-176
Hauptverfasser:	Szodoray, Peter, Alex, Philip, Jonsson, Malin V., Knowlton, Nicholas, Dozmorov, Igor, Nakken, Britt, Delaleu, Nicolas, Jonsson, Roland, Centola, Michael
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult B-Cell Activating Factor Biological and medical sciences Choristoma - immunology Circulating cytokines Cluster Analysis Cytokines - biosynthesis Cytokines - blood Ectopic germinal center Female Fundamental and applied biological sciences. Psychology Fundamental immunology Germinal Center - immunology Germinal Center - pathology Humans Immunopathology Medical sciences Membrane Proteins - biosynthesis Membrane Proteins - blood Middle Aged Multivariate Analysis Salivary Gland Diseases - immunology Salivary Glands, Minor - immunology Sjogren's Syndrome - blood Sjogren's Syndrome - immunology Sjogren's Syndrome - pathology Sjögren's syndrome Tumor Necrosis Factor-alpha - biosynthesis
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