Rosiglitazone, a peroxisome proliferator-activated receptor-γ agonist, reduces acute lung injury in endotoxemic rats

OBJECTIVE:Rosiglitazone, a potent agonist of peroxisome proliferator-activated receptor (PPAR)-γ, exerts anti-inflammatory effects in vitro and in vivo. This study was designated to determine the effects of rosiglitazone on endotoxin-induced acute lung injury in rats. DESIGN:Prospective, experimenta...

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Veröffentlicht in:	Critical care medicine 2005-10, Vol.33 (10), p.2309-2316
Hauptverfasser:	Liu, Dong, Zeng, Bang-Xiong, Zhang, Shi-Hai, Wang, Yue-Lan, Zeng, Lian, Geng, Zhi-Long, Zhang, Shi-Fan
Format:	Artikel
Sprache:	eng
Schlagworte:	Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy Anilides - pharmacology Animals Biological and medical sciences Blood. Blood coagulation. Reticuloendothelial system Emergency and intensive respiratory care Endotoxemia - chemically induced Endotoxemia - complications Endotoxemia - metabolism Intensive care medicine Lipopolysaccharides Lung - metabolism Male Medical sciences Nitric Oxide - metabolism Nitric Oxide Synthase Type II - genetics Nitric Oxide Synthase Type II - metabolism Pharmacology. Drug treatments PPAR gamma - agonists PPAR gamma - antagonists & inhibitors Rats Rats, Wistar Respiratory Distress Syndrome, Adult - etiology Respiratory Distress Syndrome, Adult - metabolism Respiratory Distress Syndrome, Adult - prevention & control RNA, Messenger - metabolism Rosiglitazone Thiazolidinediones - therapeutic use Tyrosine - analogs & derivatives Tyrosine - metabolism
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