Guidance of Bidirectional Motor Complexes by mRNA Cargoes through Control of Dynein Number and Activity

During asymmetric cytoplasmic mRNA transport, cis-acting localization signals are widely assumed to tether a specific subset of transcripts to motor complexes that have intrinsic directionality. Here we provide evidence that mRNA transcripts control their sorting by regulating the relative activitie...

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Veröffentlicht in:	Current biology 2006-07, Vol.16 (14), p.1447-1452
Hauptverfasser:	Bullock, Simon L., Nicol, Alastair, Gross, Steven P., Zicha, Daniel
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals CELLBIO Drosophila Drosophila - embryology Drosophila - genetics Drosophila - metabolism Drosophila Proteins - metabolism Drosophila Proteins - physiology Dyneins - metabolism Dyneins - physiology Embryo, Nonmammalian - metabolism Embryo, Nonmammalian - ultrastructure Microtubule-Associated Proteins - metabolism Microtubules - metabolism Models, Biological RNA RNA, Messenger - analysis RNA, Messenger - metabolism RNA, Messenger - physiology
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