The Closed Structure of an Archaeal DNA Ligase from Pyrococcus furiosus

DNA ligases join single-strand breaks in double-stranded DNA, and are essential to maintain genome integrity in DNA metabolism. Here, we report the 1.8 Å resolution structure of Pyrococcus furiosus DNA ligase (PfuLig), which represents the first full-length atomic view of an ATP-dependent eukaryotic...

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Veröffentlicht in:	Journal of molecular biology 2006-07, Vol.360 (5), p.956-967
Hauptverfasser:	Nishida, Hirokazu, Kiyonari, Shinichi, Ishino, Yoshizumi, Morikawa, Kosuke
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenosine Monophosphate - chemistry Amino Acid Sequence archaea Archaeal Proteins - chemistry Archaeal Proteins - genetics Catalytic Domain crystal structure Crystallography, X-Ray DNA ligase DNA Ligase ATP DNA Ligases - chemistry DNA Ligases - genetics DNA, Archaeal - chemistry Humans Models, Molecular Molecular Sequence Data Mutation nucleotide binding Pyrococcus furiosus Pyrococcus furiosus - enzymology Sequence Homology, Amino Acid Substrate Specificity
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