Dynamics of CD81 expression on lymphocyte subsets during interferon-α-based antiviral treatment of patients with chronic hepatitis C

CD81 is a hepatitis C virus (HCV) coreceptor with important functions in lymphocytes. During treatment, CD81 expression may be changed directly by the antiviral therapy or indirectly by reduction of the HCV serum level. The regulation of CD81 on lymphocyte subtypes has not been investigated so far a...

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Veröffentlicht in:	Journal of leukocyte biology 2006-08, Vol.80 (2), p.298-308
Hauptverfasser:	Kronenberger, Bernd, Herrmann, Eva, Hofmann, W. Peter, Wedemeyer, Heiner, Sester, Martina, Mihm, Ulrike, Ghaliai, Temam, Zeuzem, Stefan, Sarrazin, Christoph
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Antigens, CD - metabolism Antigens, CD19 - metabolism Antiviral Agents - therapeutic use antiviral immune response B-Lymphocytes - metabolism Case-Control Studies CD4-Positive T-Lymphocytes - metabolism CD56 Antigen - metabolism CD8-Positive T-Lymphocytes - metabolism Cells, Cultured Female Hepatitis C virus Hepatitis, Chronic - drug therapy Hepatitis, Chronic - metabolism host‐cell interaction Humans Interferon-alpha - therapeutic use Lymphocyte Subsets - metabolism Male Middle Aged Tetraspanin 28
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