Serum Level of Uric Acid, Partly Secreted From the Failing Heart, is a Prognostic Marker in Patients With Congestive Heart Failure
Background A recent study suggested that xanthine oxidase is activated in congestive heart failure (CHF). However, whether uric acid (UA) is secreted from the failing heart remains unknown, so it is currently unclear whether serum UA can provide prognostic information independent of brain natriureti...
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| Veröffentlicht in: | Circulation Journal 2006, Vol.70(8), pp.1006-1011 |
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| creator | Sakai, Hiroshi Tsutamoto, Takayoshi Tsutsui, Takashi Tanaka, Toshinari Ishikawa, Chitose Horie, Minoru |
| description | Background A recent study suggested that xanthine oxidase is activated in congestive heart failure (CHF). However, whether uric acid (UA) is secreted from the failing heart remains unknown, so it is currently unclear whether serum UA can provide prognostic information independent of brain natriuretic peptide (BNP). Methods and Results Serum UA was measured in the aortic root (AO) and the coronary sinus (CS) of 74 patients with CHF. The serum UA level was significantly higher in the CS than in the AO. The transcardiac gradient of UA (CS - AO) increased with the severity of CHF, inversely correlated with left ventricular ejection fraction (LVEF) and positively correlated with left ventricular end-diastolic volume index. The plasma levels of norepinephrine, BNP, UA, and LVEF were monitored prospectively in 150 CHF patients for a mean follow-up of 3 years. High plasma levels of UA (p |
| doi_str_mv | 10.1253/circj.70.1006 |
| format | Article |
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However, whether uric acid (UA) is secreted from the failing heart remains unknown, so it is currently unclear whether serum UA can provide prognostic information independent of brain natriuretic peptide (BNP). Methods and Results Serum UA was measured in the aortic root (AO) and the coronary sinus (CS) of 74 patients with CHF. The serum UA level was significantly higher in the CS than in the AO. The transcardiac gradient of UA (CS - AO) increased with the severity of CHF, inversely correlated with left ventricular ejection fraction (LVEF) and positively correlated with left ventricular end-diastolic volume index. The plasma levels of norepinephrine, BNP, UA, and LVEF were monitored prospectively in 150 CHF patients for a mean follow-up of 3 years. High plasma levels of UA (p<0.001) and BNP (p<0.001) were shown by multivariate stepwise analysis to be independent predictors of mortality. Conclusions High plasma UA level, partly secreted from the failing heart, is a prognostic predictor independent of BNP in patients with CHF. Monitoring a combination of BNP and UA may be useful for the management of patients with CHF. (Circ J 2006; 70: 1006 - 1011)</description><identifier>ISSN: 1346-9843</identifier><identifier>EISSN: 1347-4820</identifier><identifier>DOI: 10.1253/circj.70.1006</identifier><identifier>PMID: 16864933</identifier><language>eng</language><publisher>Japan: The Japanese Circulation Society</publisher><subject>Aged ; B type natriuretic peptide ; Biomarkers - blood ; Case-Control Studies ; Data Interpretation, Statistical ; Female ; Heart failure ; Heart Failure - blood ; Heart Failure - diagnosis ; Heart Failure - physiopathology ; Humans ; Male ; Middle Aged ; Multivariate Analysis ; Myocardium - metabolism ; Natriuretic Peptide, Brain - blood ; Norepinephrine - blood ; Predictive Value of Tests ; Prognosis ; Prospective Studies ; Severity of Illness Index ; Stroke Volume - physiology ; Uric acid ; Uric Acid - blood ; Ventricular Dysfunction, Left - physiopathology</subject><ispartof>Circulation Journal, 2006, Vol.70(8), pp.1006-1011</ispartof><rights>2006 THE JAPANESE CIRCULATION SOCIETY</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c479t-3dc5a5e7840ce6c6614874f75921071023706ea3b621371cfdbd49351babe4293</citedby><cites>FETCH-LOGICAL-c479t-3dc5a5e7840ce6c6614874f75921071023706ea3b621371cfdbd49351babe4293</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,778,782,1879,4012,27910,27911,27912</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/16864933$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Sakai, Hiroshi</creatorcontrib><creatorcontrib>Tsutamoto, Takayoshi</creatorcontrib><creatorcontrib>Tsutsui, Takashi</creatorcontrib><creatorcontrib>Tanaka, Toshinari</creatorcontrib><creatorcontrib>Ishikawa, Chitose</creatorcontrib><creatorcontrib>Horie, Minoru</creatorcontrib><title>Serum Level of Uric Acid, Partly Secreted From the Failing Heart, is a Prognostic Marker in Patients With Congestive Heart Failure</title><title>Circulation Journal</title><addtitle>Circ J</addtitle><description>Background A recent study suggested that xanthine oxidase is activated in congestive heart failure (CHF). However, whether uric acid (UA) is secreted from the failing heart remains unknown, so it is currently unclear whether serum UA can provide prognostic information independent of brain natriuretic peptide (BNP). Methods and Results Serum UA was measured in the aortic root (AO) and the coronary sinus (CS) of 74 patients with CHF. The serum UA level was significantly higher in the CS than in the AO. The transcardiac gradient of UA (CS - AO) increased with the severity of CHF, inversely correlated with left ventricular ejection fraction (LVEF) and positively correlated with left ventricular end-diastolic volume index. The plasma levels of norepinephrine, BNP, UA, and LVEF were monitored prospectively in 150 CHF patients for a mean follow-up of 3 years. High plasma levels of UA (p<0.001) and BNP (p<0.001) were shown by multivariate stepwise analysis to be independent predictors of mortality. Conclusions High plasma UA level, partly secreted from the failing heart, is a prognostic predictor independent of BNP in patients with CHF. Monitoring a combination of BNP and UA may be useful for the management of patients with CHF. (Circ J 2006; 70: 1006 - 1011)</description><subject>Aged</subject><subject>B type natriuretic peptide</subject><subject>Biomarkers - blood</subject><subject>Case-Control Studies</subject><subject>Data Interpretation, Statistical</subject><subject>Female</subject><subject>Heart failure</subject><subject>Heart Failure - blood</subject><subject>Heart Failure - diagnosis</subject><subject>Heart Failure - physiopathology</subject><subject>Humans</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Multivariate Analysis</subject><subject>Myocardium - metabolism</subject><subject>Natriuretic Peptide, Brain - blood</subject><subject>Norepinephrine - blood</subject><subject>Predictive Value of Tests</subject><subject>Prognosis</subject><subject>Prospective Studies</subject><subject>Severity of Illness Index</subject><subject>Stroke Volume - physiology</subject><subject>Uric acid</subject><subject>Uric Acid - blood</subject><subject>Ventricular Dysfunction, Left - physiopathology</subject><issn>1346-9843</issn><issn>1347-4820</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2006</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpFkD1PwzAQhi0EgvIxsiJPTATs2LGTESoKSEUgQcUYOc6ldclHsR0kVn45blPRxefTPffIfhE6p-Saxgm70cbq5bUMHSFiD40o4zLiaUz2N3cRZSlnR-jYuSUhcUaS7BAdUZEKnjE2Qr9vYPsGT-EbatxVeGaNxrfalFf4VVlf_-A30BY8lHhiuwb7BeCJMrVp5_gRAnGFjcMKv9pu3nbOh-1nZT_BYtMGgzfQeoc_jF_gcdfOIRDfMGxuPL2FU3RQqdrB2baeoNnk_n38GE1fHp7Gt9NIc5n5iJU6UQnIlBMNQgtBeSp5JZMspkRSEjNJBChWiJgySXVVFmX4Y0ILVQCPM3aCLgfvynZffXhJ3hinoa5VC13v8pCJyIIpgNEAats5Z6HKV9Y0yv7klOTr0PNN6LkMXQg98BdbcV80UO7obcoBuBuApfNqDv9ACMHoGna6dDjW1t1woWwOLfsDnUeVVA</recordid><startdate>2006</startdate><enddate>2006</enddate><creator>Sakai, Hiroshi</creator><creator>Tsutamoto, Takayoshi</creator><creator>Tsutsui, Takashi</creator><creator>Tanaka, Toshinari</creator><creator>Ishikawa, Chitose</creator><creator>Horie, Minoru</creator><general>The Japanese Circulation Society</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>2006</creationdate><title>Serum Level of Uric Acid, Partly Secreted From the Failing Heart, is a Prognostic Marker in Patients With Congestive Heart Failure</title><author>Sakai, Hiroshi ; Tsutamoto, Takayoshi ; Tsutsui, Takashi ; Tanaka, Toshinari ; Ishikawa, Chitose ; Horie, Minoru</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c479t-3dc5a5e7840ce6c6614874f75921071023706ea3b621371cfdbd49351babe4293</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2006</creationdate><topic>Aged</topic><topic>B type natriuretic peptide</topic><topic>Biomarkers - blood</topic><topic>Case-Control Studies</topic><topic>Data Interpretation, Statistical</topic><topic>Female</topic><topic>Heart failure</topic><topic>Heart Failure - blood</topic><topic>Heart Failure - diagnosis</topic><topic>Heart Failure - physiopathology</topic><topic>Humans</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Multivariate Analysis</topic><topic>Myocardium - metabolism</topic><topic>Natriuretic Peptide, Brain - blood</topic><topic>Norepinephrine - blood</topic><topic>Predictive Value of Tests</topic><topic>Prognosis</topic><topic>Prospective Studies</topic><topic>Severity of Illness Index</topic><topic>Stroke Volume - physiology</topic><topic>Uric acid</topic><topic>Uric Acid - blood</topic><topic>Ventricular Dysfunction, Left - physiopathology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Sakai, Hiroshi</creatorcontrib><creatorcontrib>Tsutamoto, Takayoshi</creatorcontrib><creatorcontrib>Tsutsui, Takashi</creatorcontrib><creatorcontrib>Tanaka, Toshinari</creatorcontrib><creatorcontrib>Ishikawa, Chitose</creatorcontrib><creatorcontrib>Horie, Minoru</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Circulation Journal</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Sakai, Hiroshi</au><au>Tsutamoto, Takayoshi</au><au>Tsutsui, Takashi</au><au>Tanaka, Toshinari</au><au>Ishikawa, Chitose</au><au>Horie, Minoru</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Serum Level of Uric Acid, Partly Secreted From the Failing Heart, is a Prognostic Marker in Patients With Congestive Heart Failure</atitle><jtitle>Circulation Journal</jtitle><addtitle>Circ J</addtitle><date>2006</date><risdate>2006</risdate><volume>70</volume><issue>8</issue><spage>1006</spage><epage>1011</epage><pages>1006-1011</pages><issn>1346-9843</issn><eissn>1347-4820</eissn><abstract>Background A recent study suggested that xanthine oxidase is activated in congestive heart failure (CHF). However, whether uric acid (UA) is secreted from the failing heart remains unknown, so it is currently unclear whether serum UA can provide prognostic information independent of brain natriuretic peptide (BNP). Methods and Results Serum UA was measured in the aortic root (AO) and the coronary sinus (CS) of 74 patients with CHF. The serum UA level was significantly higher in the CS than in the AO. The transcardiac gradient of UA (CS - AO) increased with the severity of CHF, inversely correlated with left ventricular ejection fraction (LVEF) and positively correlated with left ventricular end-diastolic volume index. The plasma levels of norepinephrine, BNP, UA, and LVEF were monitored prospectively in 150 CHF patients for a mean follow-up of 3 years. High plasma levels of UA (p<0.001) and BNP (p<0.001) were shown by multivariate stepwise analysis to be independent predictors of mortality. Conclusions High plasma UA level, partly secreted from the failing heart, is a prognostic predictor independent of BNP in patients with CHF. Monitoring a combination of BNP and UA may be useful for the management of patients with CHF. (Circ J 2006; 70: 1006 - 1011)</abstract><cop>Japan</cop><pub>The Japanese Circulation Society</pub><pmid>16864933</pmid><doi>10.1253/circj.70.1006</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Aged B type natriuretic peptide Biomarkers - blood Case-Control Studies Data Interpretation, Statistical Female Heart failure Heart Failure - blood Heart Failure - diagnosis Heart Failure - physiopathology Humans Male Middle Aged Multivariate Analysis Myocardium - metabolism Natriuretic Peptide, Brain - blood Norepinephrine - blood Predictive Value of Tests Prognosis Prospective Studies Severity of Illness Index Stroke Volume - physiology Uric acid Uric Acid - blood Ventricular Dysfunction, Left - physiopathology |
| title | Serum Level of Uric Acid, Partly Secreted From the Failing Heart, is a Prognostic Marker in Patients With Congestive Heart Failure |
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