V gamma 9V delta 2 T cell response to colon carcinoma cells
During analysis of CD8 T cells derived from ascites of a colon cancer patient, we isolated a Vgamma9Vdelta2 T cell clone showing strong reactivity against autologous tumor cell lines. This clone killed a large fraction of allogeneic colon carcinoma and melanoma cell lines, but did not affect a norma...
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| Veröffentlicht in: | The Journal of immunology (1950) 2005-10, Vol.175 (8), p.5481-5488 |
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| container_title | The Journal of immunology (1950) |
| container_volume | 175 |
| creator | Corvaisier, Murielle Moreau-Aubry, Agnès Diez, Elisabeth Bennouna, Jaafar Mosnier, Jean-Francois Scotet, Emmanuel Bonneville, Marc Jotereau, Francine |
| description | During analysis of CD8 T cells derived from ascites of a colon cancer patient, we isolated a Vgamma9Vdelta2 T cell clone showing strong reactivity against autologous tumor cell lines. This clone killed a large fraction of allogeneic colon carcinoma and melanoma cell lines, but did not affect a normal colon cell line, colon fibroblasts, or melanocytes. Tumor cell recognition was TCR and NKG2D dependent and induced TNF-alpha and IFN-gamma secretion by the clone; accordingly, tumor targets expressed several NKG2D ligands, such as MHC class I chain-related gene A and UL16-binding protein molecules. Colon tumor recognition by Vgamma9Vdelta2 T cells was highly dependent on isopentenyl pyrophosphate production and ICAM-1 expression by target cells. Finally, similar reactivity patterns against colon carcinoma cell lines were observed using polyclonal Vgamma9Vdelta2 T cells of various origins, and Vgamma9Vdelta2 lymphocytes were present in the majority of colon tumor samples studied. Together, these results suggest that Vgamma9Vdelta2 T cells contribute to the natural immune surveillance against colon cancers. Therefore, this study provides a strong rationale for the use of Vgamma9Vdelta2 T cell agonists in immunotherapies targeting colon tumors. |
| doi_str_mv | 10.4049/jimmunol.175.8.5481 |
| format | Article |
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This clone killed a large fraction of allogeneic colon carcinoma and melanoma cell lines, but did not affect a normal colon cell line, colon fibroblasts, or melanocytes. Tumor cell recognition was TCR and NKG2D dependent and induced TNF-alpha and IFN-gamma secretion by the clone; accordingly, tumor targets expressed several NKG2D ligands, such as MHC class I chain-related gene A and UL16-binding protein molecules. Colon tumor recognition by Vgamma9Vdelta2 T cells was highly dependent on isopentenyl pyrophosphate production and ICAM-1 expression by target cells. Finally, similar reactivity patterns against colon carcinoma cell lines were observed using polyclonal Vgamma9Vdelta2 T cells of various origins, and Vgamma9Vdelta2 lymphocytes were present in the majority of colon tumor samples studied. Together, these results suggest that Vgamma9Vdelta2 T cells contribute to the natural immune surveillance against colon cancers. Therefore, this study provides a strong rationale for the use of Vgamma9Vdelta2 T cell agonists in immunotherapies targeting colon tumors.</description><identifier>ISSN: 0022-1767</identifier><identifier>DOI: 10.4049/jimmunol.175.8.5481</identifier><identifier>PMID: 16210656</identifier><language>eng</language><publisher>United States</publisher><subject>Antigens - immunology ; Caco-2 Cells ; Cell Line, Tumor ; Clone Cells ; Colonic Neoplasms - immunology ; Colonic Neoplasms - pathology ; Cytotoxicity, Immunologic ; HCT116 Cells ; HT29 Cells ; Humans ; Intercellular Adhesion Molecule-1 - biosynthesis ; Intercellular Adhesion Molecule-1 - genetics ; NK Cell Lectin-Like Receptor Subfamily K ; Receptors, Antigen, T-Cell, gamma-delta - immunology ; Receptors, Immunologic - immunology ; Receptors, Natural Killer Cell ; T-Lymphocyte Subsets - immunology</subject><ispartof>The Journal of immunology (1950), 2005-10, Vol.175 (8), p.5481-5488</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/16210656$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Corvaisier, Murielle</creatorcontrib><creatorcontrib>Moreau-Aubry, Agnès</creatorcontrib><creatorcontrib>Diez, Elisabeth</creatorcontrib><creatorcontrib>Bennouna, Jaafar</creatorcontrib><creatorcontrib>Mosnier, Jean-Francois</creatorcontrib><creatorcontrib>Scotet, Emmanuel</creatorcontrib><creatorcontrib>Bonneville, Marc</creatorcontrib><creatorcontrib>Jotereau, Francine</creatorcontrib><title>V gamma 9V delta 2 T cell response to colon carcinoma cells</title><title>The Journal of immunology (1950)</title><addtitle>J Immunol</addtitle><description>During analysis of CD8 T cells derived from ascites of a colon cancer patient, we isolated a Vgamma9Vdelta2 T cell clone showing strong reactivity against autologous tumor cell lines. This clone killed a large fraction of allogeneic colon carcinoma and melanoma cell lines, but did not affect a normal colon cell line, colon fibroblasts, or melanocytes. Tumor cell recognition was TCR and NKG2D dependent and induced TNF-alpha and IFN-gamma secretion by the clone; accordingly, tumor targets expressed several NKG2D ligands, such as MHC class I chain-related gene A and UL16-binding protein molecules. Colon tumor recognition by Vgamma9Vdelta2 T cells was highly dependent on isopentenyl pyrophosphate production and ICAM-1 expression by target cells. Finally, similar reactivity patterns against colon carcinoma cell lines were observed using polyclonal Vgamma9Vdelta2 T cells of various origins, and Vgamma9Vdelta2 lymphocytes were present in the majority of colon tumor samples studied. Together, these results suggest that Vgamma9Vdelta2 T cells contribute to the natural immune surveillance against colon cancers. Therefore, this study provides a strong rationale for the use of Vgamma9Vdelta2 T cell agonists in immunotherapies targeting colon tumors.</description><subject>Antigens - immunology</subject><subject>Caco-2 Cells</subject><subject>Cell Line, Tumor</subject><subject>Clone Cells</subject><subject>Colonic Neoplasms - immunology</subject><subject>Colonic Neoplasms - pathology</subject><subject>Cytotoxicity, Immunologic</subject><subject>HCT116 Cells</subject><subject>HT29 Cells</subject><subject>Humans</subject><subject>Intercellular Adhesion Molecule-1 - biosynthesis</subject><subject>Intercellular Adhesion Molecule-1 - genetics</subject><subject>NK Cell Lectin-Like Receptor Subfamily K</subject><subject>Receptors, Antigen, T-Cell, gamma-delta - immunology</subject><subject>Receptors, Immunologic - immunology</subject><subject>Receptors, Natural Killer Cell</subject><subject>T-Lymphocyte Subsets - immunology</subject><issn>0022-1767</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2005</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqF0LtOwzAYBWAPIFoKT4CEPLEl_L7bYkIVN6kSS-kaOY6DUtlxiJOBt6cVZWY6y6ejo4PQDYGSAzf3-y7GuU-hJEqUuhRckzO0BKC0IEqqBbrMeQ8AEii_QAsiKQEp5BI97PCnjdFis8OND5PFFG-x8yHg0ech9dnjKWGXQuqxs6Pr-nTQR5Cv0HlrQ_bXp1yhj-en7fq12Ly_vK0fN8VAFEwF85q1VInWO0oJM1y1wlkpSNPWsjVaN1xxz8CRuoamUVYxUTslqaQCaqbYCt399g5j-pp9nqrY5eMC2_s050pqKbUx7F94OMcIIo7w9gTnOvqmGsYu2vG7-vuF_QBWpGKD</recordid><startdate>20051015</startdate><enddate>20051015</enddate><creator>Corvaisier, Murielle</creator><creator>Moreau-Aubry, Agnès</creator><creator>Diez, Elisabeth</creator><creator>Bennouna, Jaafar</creator><creator>Mosnier, Jean-Francois</creator><creator>Scotet, Emmanuel</creator><creator>Bonneville, Marc</creator><creator>Jotereau, Francine</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7T5</scope><scope>H94</scope><scope>7X8</scope></search><sort><creationdate>20051015</creationdate><title>V gamma 9V delta 2 T cell response to colon carcinoma cells</title><author>Corvaisier, Murielle ; 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This clone killed a large fraction of allogeneic colon carcinoma and melanoma cell lines, but did not affect a normal colon cell line, colon fibroblasts, or melanocytes. Tumor cell recognition was TCR and NKG2D dependent and induced TNF-alpha and IFN-gamma secretion by the clone; accordingly, tumor targets expressed several NKG2D ligands, such as MHC class I chain-related gene A and UL16-binding protein molecules. Colon tumor recognition by Vgamma9Vdelta2 T cells was highly dependent on isopentenyl pyrophosphate production and ICAM-1 expression by target cells. Finally, similar reactivity patterns against colon carcinoma cell lines were observed using polyclonal Vgamma9Vdelta2 T cells of various origins, and Vgamma9Vdelta2 lymphocytes were present in the majority of colon tumor samples studied. Together, these results suggest that Vgamma9Vdelta2 T cells contribute to the natural immune surveillance against colon cancers. Therefore, this study provides a strong rationale for the use of Vgamma9Vdelta2 T cell agonists in immunotherapies targeting colon tumors.</abstract><cop>United States</cop><pmid>16210656</pmid><doi>10.4049/jimmunol.175.8.5481</doi><tpages>8</tpages></addata></record> |
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| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Alma/SFX Local Collection |
| subjects | Antigens - immunology Caco-2 Cells Cell Line, Tumor Clone Cells Colonic Neoplasms - immunology Colonic Neoplasms - pathology Cytotoxicity, Immunologic HCT116 Cells HT29 Cells Humans Intercellular Adhesion Molecule-1 - biosynthesis Intercellular Adhesion Molecule-1 - genetics NK Cell Lectin-Like Receptor Subfamily K Receptors, Antigen, T-Cell, gamma-delta - immunology Receptors, Immunologic - immunology Receptors, Natural Killer Cell T-Lymphocyte Subsets - immunology |
| title | V gamma 9V delta 2 T cell response to colon carcinoma cells |
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