The molecular players of sperm–egg fusion in mammals
Fertilization includes a series of cellular interactions culminating with the fusion of gamete membranes, creating a zygote. Two ADAM proteins present on sperm, fertilin β and cyritestin, drew much attention. However, gene deletion in mice showed that fusion can happen in their absence. The presence...
Gespeichert in:
| Veröffentlicht in: | Seminars in cell & developmental biology 2006-04, Vol.17 (2), p.254-263 |
|---|---|
| Hauptverfasser: | , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 263 |
|---|---|
| container_issue | 2 |
| container_start_page | 254 |
| container_title | Seminars in cell & developmental biology |
| container_volume | 17 |
| creator | Rubinstein, Eric Ziyyat, Ahmed Wolf, Jean-Philippe Le Naour, François Boucheix, Claude |
| description | Fertilization includes a series of cellular interactions culminating with the fusion of gamete membranes, creating a zygote. Two ADAM proteins present on sperm, fertilin β and cyritestin, drew much attention. However, gene deletion in mice showed that fusion can happen in their absence. The presence of the integrin α6β1 on egg, a putative fertilin β receptor, is also dispensable. In contrast, sperm lacking Izumo, a molecule with a single Ig domain, are unable to fuse. On the egg side, a role for GPI-anchored molecules has been shown, and in mice lacking both tetraspanins CD9 and CD81 fertilization is completely blocked. |
| doi_str_mv | 10.1016/j.semcdb.2006.02.012 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_68668465</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S1084952106000218</els_id><sourcerecordid>68668465</sourcerecordid><originalsourceid>FETCH-LOGICAL-c360t-6b7edab16bbd3a1f4f3e5c6466a4db4f84b778dfa2191b1c8643cdd208fda6f03</originalsourceid><addsrcrecordid>eNp9kMtKw0AUhgdRrFbfQCQrd4kzyeQk2QhSvEHBTV0PczlTUzJJnGmE7nwH39AnMSUFd67OWXz_fzgfIVeMJowyuN0kAZ02KkkphYSmCWXpETljtII4g4wf7_eSx1Weshk5D2FDKeVVCqdkxiAvOOfsjMDqHSPXNaiHRvqob-QOfYg6G4Uevfv5-sb1OrJDqLs2qtvISedkEy7IiR0HXh7mnLw9PqwWz_Hy9ellcb-MdQZ0G4Mq0EjFQCmTSWa5zTDXwAEkN4rbkquiKI2VKauYYroEnmljUlpaI8HSbE5upt7edx8Dhq1wddDYNLLFbggCSoCSQz6CfAK170LwaEXvayf9TjAq9r7ERky-xN6XoKkYfY2x60P_oByav9BB0AjcTQCOX37W6EXQNbYaTe1Rb4Xp6v8v_ALDLX7L</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>68668465</pqid></control><display><type>article</type><title>The molecular players of sperm–egg fusion in mammals</title><source>MEDLINE</source><source>Elsevier ScienceDirect Journals</source><creator>Rubinstein, Eric ; Ziyyat, Ahmed ; Wolf, Jean-Philippe ; Le Naour, François ; Boucheix, Claude</creator><creatorcontrib>Rubinstein, Eric ; Ziyyat, Ahmed ; Wolf, Jean-Philippe ; Le Naour, François ; Boucheix, Claude</creatorcontrib><description>Fertilization includes a series of cellular interactions culminating with the fusion of gamete membranes, creating a zygote. Two ADAM proteins present on sperm, fertilin β and cyritestin, drew much attention. However, gene deletion in mice showed that fusion can happen in their absence. The presence of the integrin α6β1 on egg, a putative fertilin β receptor, is also dispensable. In contrast, sperm lacking Izumo, a molecule with a single Ig domain, are unable to fuse. On the egg side, a role for GPI-anchored molecules has been shown, and in mice lacking both tetraspanins CD9 and CD81 fertilization is completely blocked.</description><identifier>ISSN: 1084-9521</identifier><identifier>EISSN: 1096-3634</identifier><identifier>DOI: 10.1016/j.semcdb.2006.02.012</identifier><identifier>PMID: 16574441</identifier><language>eng</language><publisher>England: Elsevier Ltd</publisher><subject>ADAM Proteins - metabolism ; Animals ; Antigens, CD - metabolism ; CD9 ; Female ; Fusion ; Integrin alpha6beta1 - metabolism ; Izumo ; Male ; Membrane Fusion ; Membrane Glycoproteins - metabolism ; Membrane Proteins - metabolism ; Mice ; Models, Biological ; Oocyte ; Sperm ; Sperm-Ovum Interactions ; Tetraspanin-29</subject><ispartof>Seminars in cell & developmental biology, 2006-04, Vol.17 (2), p.254-263</ispartof><rights>2006 Elsevier Ltd</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c360t-6b7edab16bbd3a1f4f3e5c6466a4db4f84b778dfa2191b1c8643cdd208fda6f03</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.semcdb.2006.02.012$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3536,27903,27904,45974</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/16574441$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Rubinstein, Eric</creatorcontrib><creatorcontrib>Ziyyat, Ahmed</creatorcontrib><creatorcontrib>Wolf, Jean-Philippe</creatorcontrib><creatorcontrib>Le Naour, François</creatorcontrib><creatorcontrib>Boucheix, Claude</creatorcontrib><title>The molecular players of sperm–egg fusion in mammals</title><title>Seminars in cell & developmental biology</title><addtitle>Semin Cell Dev Biol</addtitle><description>Fertilization includes a series of cellular interactions culminating with the fusion of gamete membranes, creating a zygote. Two ADAM proteins present on sperm, fertilin β and cyritestin, drew much attention. However, gene deletion in mice showed that fusion can happen in their absence. The presence of the integrin α6β1 on egg, a putative fertilin β receptor, is also dispensable. In contrast, sperm lacking Izumo, a molecule with a single Ig domain, are unable to fuse. On the egg side, a role for GPI-anchored molecules has been shown, and in mice lacking both tetraspanins CD9 and CD81 fertilization is completely blocked.</description><subject>ADAM Proteins - metabolism</subject><subject>Animals</subject><subject>Antigens, CD - metabolism</subject><subject>CD9</subject><subject>Female</subject><subject>Fusion</subject><subject>Integrin alpha6beta1 - metabolism</subject><subject>Izumo</subject><subject>Male</subject><subject>Membrane Fusion</subject><subject>Membrane Glycoproteins - metabolism</subject><subject>Membrane Proteins - metabolism</subject><subject>Mice</subject><subject>Models, Biological</subject><subject>Oocyte</subject><subject>Sperm</subject><subject>Sperm-Ovum Interactions</subject><subject>Tetraspanin-29</subject><issn>1084-9521</issn><issn>1096-3634</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2006</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kMtKw0AUhgdRrFbfQCQrd4kzyeQk2QhSvEHBTV0PczlTUzJJnGmE7nwH39AnMSUFd67OWXz_fzgfIVeMJowyuN0kAZ02KkkphYSmCWXpETljtII4g4wf7_eSx1Weshk5D2FDKeVVCqdkxiAvOOfsjMDqHSPXNaiHRvqob-QOfYg6G4Uevfv5-sb1OrJDqLs2qtvISedkEy7IiR0HXh7mnLw9PqwWz_Hy9ellcb-MdQZ0G4Mq0EjFQCmTSWa5zTDXwAEkN4rbkquiKI2VKauYYroEnmljUlpaI8HSbE5upt7edx8Dhq1wddDYNLLFbggCSoCSQz6CfAK170LwaEXvayf9TjAq9r7ERky-xN6XoKkYfY2x60P_oByav9BB0AjcTQCOX37W6EXQNbYaTe1Rb4Xp6v8v_ALDLX7L</recordid><startdate>20060401</startdate><enddate>20060401</enddate><creator>Rubinstein, Eric</creator><creator>Ziyyat, Ahmed</creator><creator>Wolf, Jean-Philippe</creator><creator>Le Naour, François</creator><creator>Boucheix, Claude</creator><general>Elsevier Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20060401</creationdate><title>The molecular players of sperm–egg fusion in mammals</title><author>Rubinstein, Eric ; Ziyyat, Ahmed ; Wolf, Jean-Philippe ; Le Naour, François ; Boucheix, Claude</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c360t-6b7edab16bbd3a1f4f3e5c6466a4db4f84b778dfa2191b1c8643cdd208fda6f03</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2006</creationdate><topic>ADAM Proteins - metabolism</topic><topic>Animals</topic><topic>Antigens, CD - metabolism</topic><topic>CD9</topic><topic>Female</topic><topic>Fusion</topic><topic>Integrin alpha6beta1 - metabolism</topic><topic>Izumo</topic><topic>Male</topic><topic>Membrane Fusion</topic><topic>Membrane Glycoproteins - metabolism</topic><topic>Membrane Proteins - metabolism</topic><topic>Mice</topic><topic>Models, Biological</topic><topic>Oocyte</topic><topic>Sperm</topic><topic>Sperm-Ovum Interactions</topic><topic>Tetraspanin-29</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Rubinstein, Eric</creatorcontrib><creatorcontrib>Ziyyat, Ahmed</creatorcontrib><creatorcontrib>Wolf, Jean-Philippe</creatorcontrib><creatorcontrib>Le Naour, François</creatorcontrib><creatorcontrib>Boucheix, Claude</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Seminars in cell & developmental biology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Rubinstein, Eric</au><au>Ziyyat, Ahmed</au><au>Wolf, Jean-Philippe</au><au>Le Naour, François</au><au>Boucheix, Claude</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The molecular players of sperm–egg fusion in mammals</atitle><jtitle>Seminars in cell & developmental biology</jtitle><addtitle>Semin Cell Dev Biol</addtitle><date>2006-04-01</date><risdate>2006</risdate><volume>17</volume><issue>2</issue><spage>254</spage><epage>263</epage><pages>254-263</pages><issn>1084-9521</issn><eissn>1096-3634</eissn><abstract>Fertilization includes a series of cellular interactions culminating with the fusion of gamete membranes, creating a zygote. Two ADAM proteins present on sperm, fertilin β and cyritestin, drew much attention. However, gene deletion in mice showed that fusion can happen in their absence. The presence of the integrin α6β1 on egg, a putative fertilin β receptor, is also dispensable. In contrast, sperm lacking Izumo, a molecule with a single Ig domain, are unable to fuse. On the egg side, a role for GPI-anchored molecules has been shown, and in mice lacking both tetraspanins CD9 and CD81 fertilization is completely blocked.</abstract><cop>England</cop><pub>Elsevier Ltd</pub><pmid>16574441</pmid><doi>10.1016/j.semcdb.2006.02.012</doi><tpages>10</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1084-9521 |
| ispartof | Seminars in cell & developmental biology, 2006-04, Vol.17 (2), p.254-263 |
| issn | 1084-9521 1096-3634 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_68668465 |
| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | ADAM Proteins - metabolism Animals Antigens, CD - metabolism CD9 Female Fusion Integrin alpha6beta1 - metabolism Izumo Male Membrane Fusion Membrane Glycoproteins - metabolism Membrane Proteins - metabolism Mice Models, Biological Oocyte Sperm Sperm-Ovum Interactions Tetraspanin-29 |
| title | The molecular players of sperm–egg fusion in mammals |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-22T02%3A21%3A50IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=The%20molecular%20players%20of%20sperm%E2%80%93egg%20fusion%20in%20mammals&rft.jtitle=Seminars%20in%20cell%20&%20developmental%20biology&rft.au=Rubinstein,%20Eric&rft.date=2006-04-01&rft.volume=17&rft.issue=2&rft.spage=254&rft.epage=263&rft.pages=254-263&rft.issn=1084-9521&rft.eissn=1096-3634&rft_id=info:doi/10.1016/j.semcdb.2006.02.012&rft_dat=%3Cproquest_cross%3E68668465%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=68668465&rft_id=info:pmid/16574441&rft_els_id=S1084952106000218&rfr_iscdi=true |