Transcriptional control of Pactolus: evidence of a negative control region and comparison with its evolutionary paralogue, CD18 (β2 integrin)

The mouse Pactolus and CD18 genes are highly conserved paralogues. The expression patterns of these genes are diverse in that most cells of hematopoietic lineage express CD18, but Pactolus is only expressed by maturing neutrophils. The minimal promoters of these two genes are homologous, including t...

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Veröffentlicht in:	Journal of leukocyte biology 2006-08, Vol.80 (2), p.383-398
Hauptverfasser:	Hale, J. Scott, Dahlem, Timothy J., Margraf, Rebecca L., Debnath, Irina, Weis, Janis J., Weis, John H.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Base Sequence Binding Sites CD18 Antigens - genetics Cell Line Down-Regulation Evolution, Molecular Gene Expression Regulation granulocytes Integrin beta1 - genetics macrophages Mice Molecular Sequence Data neutrophils Promoter Regions, Genetic Proto-Oncogene Proteins - genetics Snail Family Transcription Factors Trans-Activators - genetics Transcription Factors - metabolism Transcription, Genetic Transfection
Online-Zugang:	Volltext
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