A genetic basis for IFN-gamma production and T-bet expression in humans

Th1 and Th2 cytokines secreted by polarized effector T cells play a pivotal role in the development of autoimmune and allergic diseases. However, the genetic basis of cytokine production by T lymphocytes in humans is poorly understood. In this study, we investigated the genetic contribution to cytok...

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Veröffentlicht in:	The Journal of immunology (1950) 2005-10, Vol.175 (8), p.5457-5462
Hauptverfasser:	Höhler, Thomas, Reuss, Esther, Adams, Petra, Bartsch, Brigitte, Weigmann, Benno, Wörns, Markus, Galle, Peter R, Victor, Anja, Neurath, Markus F
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescent Adult Age Factors Aged Body Mass Index Cells, Cultured Female GATA3 Transcription Factor - metabolism Humans Interferon-gamma - biosynthesis Interferon-gamma - genetics Interleukin-4 - biosynthesis Interleukin-4 - genetics Male Middle Aged NF-kappa B - metabolism NFATC Transcription Factors - metabolism Prospective Studies Sex Factors T-Box Domain Proteins Transcription Factors - biosynthesis Transcription Factors - genetics Tumor Necrosis Factor-alpha - biosynthesis Tumor Necrosis Factor-alpha - genetics
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