Requirement for Neutralizing Antibodies to Control Bone Marrow Transplantation-Associated Persistent Viral Infection and to Reduce Immunopathology

Bone marrow transplantation (BMT) is commonly used in the treatment of leukemia, however its therapeutic application is partly limited by the high incidence of associated opportunistic infections. We modeled this clinical situation by infecting mice that underwent BMT with lymphocytic choriomeningit...

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Veröffentlicht in:	Journal of Immunology 2005-10, Vol.175 (8), p.5524-5531
Hauptverfasser:	Lang, Karl S, Recher, Mike, Navarini, Alexander A, Freigang, Stefan, Harris, Nicola L, van den Broek, Maries, Odermatt, Bernhard, Hengartner, Hans, Zinkernagel, Rolf M
Format:	Artikel
Sprache:	eng
Schlagworte:	Adoptive Transfer Animals Antibodies - therapeutic use Bone Marrow Transplantation - immunology Bone Marrow Transplantation - pathology CD8-Positive T-Lymphocytes - immunology Immunization, Passive Lymphocytic Choriomeningitis - immunology Lymphocytic Choriomeningitis - pathology Lymphocytic Choriomeningitis - therapy Lymphocytic choriomeningitis virus Lymphocytic choriomeningitis virus - immunology Mice Mice, Inbred C57BL Mice, Transgenic Opportunistic Infections - immunology Opportunistic Infections - pathology Opportunistic Infections - therapy Spleen - cytology Spleen - immunology Viremia - immunology Viremia - pathology Viremia - therapy Virus Replication - immunology
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