Is MHC enough for understanding wildlife immunogenetics?
Along with reproductive success and predation, infectious disease is a major demographic and evolutionary driver of natural populations. To understand the evolutionary impacts of disease, research has focussed on the major histocompatibility complex (MHC), a genetic region involved in antigen presen...
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| Veröffentlicht in: | Trends in ecology & evolution (Amsterdam) 2006-08, Vol.21 (8), p.433-438 |
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| container_title | Trends in ecology & evolution (Amsterdam) |
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| creator | Acevedo-Whitehouse, Karina Cunningham, Andrew A. |
| description | Along with reproductive success and predation, infectious disease is a major demographic and evolutionary driver of natural populations. To understand the evolutionary impacts of disease, research has focussed on the major histocompatibility complex (MHC), a genetic region involved in antigen presentation. There is a pressing need for the broader research currently conducted on traditional vertebrate models to be transferred to wildlife. Incorporating such knowledge will enable a broader understanding of the levels at which natural selection can act on immunity. We propose two new approaches to wildlife immunogenetics and discuss the challenges of conducting such studies. At a time when novel pathogens are increasingly emerging in natural populations, these new approaches are integral to understanding disease dynamics and assessing epidemic risks. |
| doi_str_mv | 10.1016/j.tree.2006.05.010 |
| format | Article |
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| ispartof | Trends in ecology & evolution (Amsterdam), 2006-08, Vol.21 (8), p.433-438 |
| issn | 0169-5347 1872-8383 |
| language | eng |
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| source | MEDLINE; Access via ScienceDirect (Elsevier) |
| subjects | Animal and plant ecology Animal, plant and microbial ecology Animals Animals, Wild - genetics Animals, Wild - immunology Biological and medical sciences Fundamental and applied biological sciences. Psychology General aspects Genetic Markers Major Histocompatibility Complex - immunology |
| title | Is MHC enough for understanding wildlife immunogenetics? |
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