Unusually High Frequency MHC Class I Alleles in Mauritian Origin Cynomolgus Macaques
Acute shortages of Indian origin Rhesus macaques significantly hinder HIV/AIDS research. Cellular immune responses are particularly difficult to study because only a subset of animals possess MHC class I (MHC I) alleles with defined peptide-binding specificities. To expand the pool of nonhuman prima...
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| Veröffentlicht in: | The Journal of immunology (1950) 2005-10, Vol.175 (8), p.5230-5239 |
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| container_issue | 8 |
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| container_title | The Journal of immunology (1950) |
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| creator | Krebs, Kendall C Jin, ZheYuan Rudersdorf, Richard Hughes, Austin L O'Connor, David H |
| description | Acute shortages of Indian origin Rhesus macaques significantly hinder HIV/AIDS research. Cellular immune responses are particularly difficult to study because only a subset of animals possess MHC class I (MHC I) alleles with defined peptide-binding specificities. To expand the pool of nonhuman primates suitable for studies of cellular immunity, we defined 66 MHC I alleles in Cynomolgus macaques (Macaca fascicularis) of Chinese, Vietnamese, and Mauritian origin. Most MHC I alleles were found only in animals from a single geographic origin, suggesting that Cynomolgus macaques from different origins are not interchangeable in studies of cellular immunity. Animals from Mauritius may be particularly valuable because >50% of these Cynomolgus macaques share the MHC class I allele combination Mafa-B*430101, Mafa-B*440101, and Mafa-B*460101. The increased MHC I allele sharing of Mauritian origin Cynomolgus macaques may dramatically reduce the overall number of animals needed to study cellular immune responses in nonhuman primates while simultaneously reducing the confounding effects of genetic heterogeneity in HIV/AIDS research. |
| doi_str_mv | 10.4049/jimmunol.175.8.5230 |
| format | Article |
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The increased MHC I allele sharing of Mauritian origin Cynomolgus macaques may dramatically reduce the overall number of animals needed to study cellular immune responses in nonhuman primates while simultaneously reducing the confounding effects of genetic heterogeneity in HIV/AIDS research.</description><identifier>ISSN: 0022-1767</identifier><identifier>EISSN: 1550-6606</identifier><identifier>DOI: 10.4049/jimmunol.175.8.5230</identifier><identifier>PMID: 16210628</identifier><language>eng</language><publisher>United States: Am Assoc Immnol</publisher><subject>Alleles ; Animals ; Cells, Cultured ; Gene Frequency ; Genotype ; Histocompatibility Antigens Class I - biosynthesis ; Histocompatibility Antigens Class I - genetics ; Human immunodeficiency virus ; Leukocytes, Mononuclear ; Macaca fascicularis ; Macaca fascicularis - genetics ; Macaca fascicularis - immunology ; Macaca mulatta ; Mauritius ; Primates</subject><ispartof>The Journal of immunology (1950), 2005-10, Vol.175 (8), p.5230-5239</ispartof><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c477t-c9cd5c6af1110f325cadf47edcd5d3ed6841487fb7cc3601946a53822bf4f48f3</citedby><cites>FETCH-LOGICAL-c477t-c9cd5c6af1110f325cadf47edcd5d3ed6841487fb7cc3601946a53822bf4f48f3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>315,782,786,27931,27932</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/16210628$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Krebs, Kendall C</creatorcontrib><creatorcontrib>Jin, ZheYuan</creatorcontrib><creatorcontrib>Rudersdorf, Richard</creatorcontrib><creatorcontrib>Hughes, Austin L</creatorcontrib><creatorcontrib>O'Connor, David H</creatorcontrib><title>Unusually High Frequency MHC Class I Alleles in Mauritian Origin Cynomolgus Macaques</title><title>The Journal of immunology (1950)</title><addtitle>J Immunol</addtitle><description>Acute shortages of Indian origin Rhesus macaques significantly hinder HIV/AIDS research. Cellular immune responses are particularly difficult to study because only a subset of animals possess MHC class I (MHC I) alleles with defined peptide-binding specificities. To expand the pool of nonhuman primates suitable for studies of cellular immunity, we defined 66 MHC I alleles in Cynomolgus macaques (Macaca fascicularis) of Chinese, Vietnamese, and Mauritian origin. Most MHC I alleles were found only in animals from a single geographic origin, suggesting that Cynomolgus macaques from different origins are not interchangeable in studies of cellular immunity. Animals from Mauritius may be particularly valuable because >50% of these Cynomolgus macaques share the MHC class I allele combination Mafa-B*430101, Mafa-B*440101, and Mafa-B*460101. The increased MHC I allele sharing of Mauritian origin Cynomolgus macaques may dramatically reduce the overall number of animals needed to study cellular immune responses in nonhuman primates while simultaneously reducing the confounding effects of genetic heterogeneity in HIV/AIDS research.</description><subject>Alleles</subject><subject>Animals</subject><subject>Cells, Cultured</subject><subject>Gene Frequency</subject><subject>Genotype</subject><subject>Histocompatibility Antigens Class I - biosynthesis</subject><subject>Histocompatibility Antigens Class I - genetics</subject><subject>Human immunodeficiency virus</subject><subject>Leukocytes, Mononuclear</subject><subject>Macaca fascicularis</subject><subject>Macaca fascicularis - genetics</subject><subject>Macaca fascicularis - immunology</subject><subject>Macaca mulatta</subject><subject>Mauritius</subject><subject>Primates</subject><issn>0022-1767</issn><issn>1550-6606</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2005</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkEFrwjAYhsPYmM7tFwxGTtupLknTpB6lzCkoXvQcYppoJG1dYhH__VJ0bLedPvi-530_eAB4xmhIER29721VtXXjhphnw3yYkRTdgD7OMpQwhtgt6CNESII54z3wEMIeIcQQofeghxnBiJG8D1brug2tdO4Mp3a7gxOvv1pdqzNcTAtYOBkCnMGxc9rpAG0NF7L19mhlDZfebuOiONdN1bhtG-JNyZgOj-DOSBf003UOwHrysSqmyXz5OSvG80RRzo-JGqkyU0wajDEyKcmULA3luozrMtUlyymmOTcbrlTKEB5RJrM0J2RjqKG5SQfg9dJ78E339ygqG5R2Tta6aYNgOWMZwvhfMBocEcJpBNMLqHwTgtdGHLytpD8LjERnXfxY7zIiF531mHq51rebSpe_mavmCLxdgF10fLJei1BF5xHH4nQ6_an6BsLxjZo</recordid><startdate>20051015</startdate><enddate>20051015</enddate><creator>Krebs, Kendall C</creator><creator>Jin, ZheYuan</creator><creator>Rudersdorf, Richard</creator><creator>Hughes, Austin L</creator><creator>O'Connor, David H</creator><general>Am Assoc Immnol</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>H94</scope><scope>7X8</scope></search><sort><creationdate>20051015</creationdate><title>Unusually High Frequency MHC Class I Alleles in Mauritian Origin Cynomolgus Macaques</title><author>Krebs, Kendall C ; Jin, ZheYuan ; Rudersdorf, Richard ; Hughes, Austin L ; O'Connor, David H</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c477t-c9cd5c6af1110f325cadf47edcd5d3ed6841487fb7cc3601946a53822bf4f48f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2005</creationdate><topic>Alleles</topic><topic>Animals</topic><topic>Cells, Cultured</topic><topic>Gene Frequency</topic><topic>Genotype</topic><topic>Histocompatibility Antigens Class I - biosynthesis</topic><topic>Histocompatibility Antigens Class I - genetics</topic><topic>Human immunodeficiency virus</topic><topic>Leukocytes, Mononuclear</topic><topic>Macaca fascicularis</topic><topic>Macaca fascicularis - genetics</topic><topic>Macaca fascicularis - immunology</topic><topic>Macaca mulatta</topic><topic>Mauritius</topic><topic>Primates</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Krebs, Kendall C</creatorcontrib><creatorcontrib>Jin, ZheYuan</creatorcontrib><creatorcontrib>Rudersdorf, Richard</creatorcontrib><creatorcontrib>Hughes, Austin L</creatorcontrib><creatorcontrib>O'Connor, David H</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>The Journal of immunology (1950)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Krebs, Kendall C</au><au>Jin, ZheYuan</au><au>Rudersdorf, Richard</au><au>Hughes, Austin L</au><au>O'Connor, David H</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Unusually High Frequency MHC Class I Alleles in Mauritian Origin Cynomolgus Macaques</atitle><jtitle>The Journal of immunology (1950)</jtitle><addtitle>J Immunol</addtitle><date>2005-10-15</date><risdate>2005</risdate><volume>175</volume><issue>8</issue><spage>5230</spage><epage>5239</epage><pages>5230-5239</pages><issn>0022-1767</issn><eissn>1550-6606</eissn><abstract>Acute shortages of Indian origin Rhesus macaques significantly hinder HIV/AIDS research. Cellular immune responses are particularly difficult to study because only a subset of animals possess MHC class I (MHC I) alleles with defined peptide-binding specificities. To expand the pool of nonhuman primates suitable for studies of cellular immunity, we defined 66 MHC I alleles in Cynomolgus macaques (Macaca fascicularis) of Chinese, Vietnamese, and Mauritian origin. Most MHC I alleles were found only in animals from a single geographic origin, suggesting that Cynomolgus macaques from different origins are not interchangeable in studies of cellular immunity. Animals from Mauritius may be particularly valuable because >50% of these Cynomolgus macaques share the MHC class I allele combination Mafa-B*430101, Mafa-B*440101, and Mafa-B*460101. The increased MHC I allele sharing of Mauritian origin Cynomolgus macaques may dramatically reduce the overall number of animals needed to study cellular immune responses in nonhuman primates while simultaneously reducing the confounding effects of genetic heterogeneity in HIV/AIDS research.</abstract><cop>United States</cop><pub>Am Assoc Immnol</pub><pmid>16210628</pmid><doi>10.4049/jimmunol.175.8.5230</doi><tpages>10</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | The Journal of immunology (1950), 2005-10, Vol.175 (8), p.5230-5239 |
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| source | MEDLINE; EZB-FREE-00999 freely available EZB journals; Alma/SFX Local Collection |
| subjects | Alleles Animals Cells, Cultured Gene Frequency Genotype Histocompatibility Antigens Class I - biosynthesis Histocompatibility Antigens Class I - genetics Human immunodeficiency virus Leukocytes, Mononuclear Macaca fascicularis Macaca fascicularis - genetics Macaca fascicularis - immunology Macaca mulatta Mauritius Primates |
| title | Unusually High Frequency MHC Class I Alleles in Mauritian Origin Cynomolgus Macaques |
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