The value of FDG-PET and bone scintigraphy with SPECT in the primary diagnosis and follow-up of patients with chronic osteomyelitis of the mandible
To appraise the value of FDG-PET and bone scintigraphy using SPECT in the primary diagnosis and follow-up of patients with chronic osteomyelitis of the mandible (COM). In a prospective study the pattern of tracer uptake was investigated using 2 diagnostic methods in 42 patients. Results were compare...
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| Veröffentlicht in: | International journal of oral and maxillofacial surgery 2006-09, Vol.35 (9), p.809-816 |
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| container_title | International journal of oral and maxillofacial surgery |
| container_volume | 35 |
| creator | Hakim, S.G. Bruecker, C.W.R. Jacobsen, H.Ch Hermes, D. Lauer, I. Eckerle, S. Froehlich, A. Sieg, P. |
| description | To appraise the value of FDG-PET and bone scintigraphy using SPECT in the primary diagnosis and follow-up of patients with chronic osteomyelitis of the mandible (COM).
In a prospective study the pattern of tracer uptake was investigated using 2 diagnostic methods in 42 patients. Results were compared with histology and radiographs as well as clinical and laboratory parameters.
The use of FDG-PET in the primary diagnosis of COM resulted in a sensitivity of 64% and a specificity of 77.7%. The sensitivity of SPECT was 84% and the specificity 33.3%.
During the follow-up period of these patients the sensitivity of SPECT increased to 93.7%, while the specificity decreased (6.6%). The sensitivity and specificity of FDG-PET for this follow-up group were 62.5 and 80%, respectively.
Because of its high sensitivity, SPECT is vastly superior to other diagnostic methods in initiating treatment. In the follow-up period it might be replaced by FDG-PET, which reflects the disease course better and indicates the time of clinical remission. |
| doi_str_mv | 10.1016/j.ijom.2006.03.029 |
| format | Article |
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In a prospective study the pattern of tracer uptake was investigated using 2 diagnostic methods in 42 patients. Results were compared with histology and radiographs as well as clinical and laboratory parameters.
The use of FDG-PET in the primary diagnosis of COM resulted in a sensitivity of 64% and a specificity of 77.7%. The sensitivity of SPECT was 84% and the specificity 33.3%.
During the follow-up period of these patients the sensitivity of SPECT increased to 93.7%, while the specificity decreased (6.6%). The sensitivity and specificity of FDG-PET for this follow-up group were 62.5 and 80%, respectively.
Because of its high sensitivity, SPECT is vastly superior to other diagnostic methods in initiating treatment. In the follow-up period it might be replaced by FDG-PET, which reflects the disease course better and indicates the time of clinical remission.</description><identifier>ISSN: 0901-5027</identifier><identifier>EISSN: 1399-0020</identifier><identifier>DOI: 10.1016/j.ijom.2006.03.029</identifier><identifier>PMID: 16829036</identifier><identifier>CODEN: IJOSE9</identifier><language>eng</language><publisher>Amsterdam: Elsevier Ltd</publisher><subject>Adult ; Aged ; Aged, 80 and over ; Bacterial arthritis and osteitis ; Bacterial diseases ; Biological and medical sciences ; Chronic Disease ; Dentistry ; diagnosis ; False Negative Reactions ; False Positive Reactions ; Fluorodeoxyglucose F18 ; follow-up ; Human bacterial diseases ; Humans ; Infectious diseases ; mandible ; Mandible - diagnostic imaging ; Mandible - surgery ; Medical sciences ; Middle Aged ; osteomyelitis ; Osteomyelitis - diagnostic imaging ; Osteomyelitis - surgery ; Otorhinolaryngology. Stomatology ; PET ; Positron-Emission Tomography ; Predictive Value of Tests ; Prospective Studies ; Radiopharmaceuticals ; Sensitivity and Specificity ; SPECT ; Time Factors ; Tomography, Emission-Computed, Single-Photon</subject><ispartof>International journal of oral and maxillofacial surgery, 2006-09, Vol.35 (9), p.809-816</ispartof><rights>2006 International Association of Oral and Maxillofacial Surgeons</rights><rights>2006 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c384t-f8c5b4716813ed6f8e19bc6de2037568405cba9f156845789b0f5d74446415433</citedby><cites>FETCH-LOGICAL-c384t-f8c5b4716813ed6f8e19bc6de2037568405cba9f156845789b0f5d74446415433</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.ijom.2006.03.029$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=17992245$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/16829036$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Hakim, S.G.</creatorcontrib><creatorcontrib>Bruecker, C.W.R.</creatorcontrib><creatorcontrib>Jacobsen, H.Ch</creatorcontrib><creatorcontrib>Hermes, D.</creatorcontrib><creatorcontrib>Lauer, I.</creatorcontrib><creatorcontrib>Eckerle, S.</creatorcontrib><creatorcontrib>Froehlich, A.</creatorcontrib><creatorcontrib>Sieg, P.</creatorcontrib><title>The value of FDG-PET and bone scintigraphy with SPECT in the primary diagnosis and follow-up of patients with chronic osteomyelitis of the mandible</title><title>International journal of oral and maxillofacial surgery</title><addtitle>Int J Oral Maxillofac Surg</addtitle><description>To appraise the value of FDG-PET and bone scintigraphy using SPECT in the primary diagnosis and follow-up of patients with chronic osteomyelitis of the mandible (COM).
In a prospective study the pattern of tracer uptake was investigated using 2 diagnostic methods in 42 patients. Results were compared with histology and radiographs as well as clinical and laboratory parameters.
The use of FDG-PET in the primary diagnosis of COM resulted in a sensitivity of 64% and a specificity of 77.7%. The sensitivity of SPECT was 84% and the specificity 33.3%.
During the follow-up period of these patients the sensitivity of SPECT increased to 93.7%, while the specificity decreased (6.6%). The sensitivity and specificity of FDG-PET for this follow-up group were 62.5 and 80%, respectively.
Because of its high sensitivity, SPECT is vastly superior to other diagnostic methods in initiating treatment. In the follow-up period it might be replaced by FDG-PET, which reflects the disease course better and indicates the time of clinical remission.</description><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Bacterial arthritis and osteitis</subject><subject>Bacterial diseases</subject><subject>Biological and medical sciences</subject><subject>Chronic Disease</subject><subject>Dentistry</subject><subject>diagnosis</subject><subject>False Negative Reactions</subject><subject>False Positive Reactions</subject><subject>Fluorodeoxyglucose F18</subject><subject>follow-up</subject><subject>Human bacterial diseases</subject><subject>Humans</subject><subject>Infectious diseases</subject><subject>mandible</subject><subject>Mandible - diagnostic imaging</subject><subject>Mandible - surgery</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>osteomyelitis</subject><subject>Osteomyelitis - diagnostic imaging</subject><subject>Osteomyelitis - surgery</subject><subject>Otorhinolaryngology. Stomatology</subject><subject>PET</subject><subject>Positron-Emission Tomography</subject><subject>Predictive Value of Tests</subject><subject>Prospective Studies</subject><subject>Radiopharmaceuticals</subject><subject>Sensitivity and Specificity</subject><subject>SPECT</subject><subject>Time Factors</subject><subject>Tomography, Emission-Computed, Single-Photon</subject><issn>0901-5027</issn><issn>1399-0020</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2006</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kcFu1DAURSMEokPhB1ggb2CX8BwnTiyxQdNpqVSJSgxry3FeOh4ldrCTVvMd_DAOE6m7ruzFOdd-7ybJRwoZBcq_HjNzdEOWA_AMWAa5eJVsKBMiBcjhdbIBATQtIa8uknchHAFAsLp6m1xQXucCGN8kf_cHJI-qn5G4jlxf3aT3uz1RtiWNs0iCNnYyD16NhxN5MtOB_LrfbffEWDJFcfRmUP5EWqMerAsm_Dc71_fuKZ3HJXJUk0E7hbOtD95Zo4kLE7rhhL2ZohSxJW2Isml6fJ-86VQf8MN6Xia_r3f77Y_07ufN7fb7XapZXUxpV-uyKao4C2XY8q5GKhrNW8yBVSWvCyh1o0RHl3tZ1aKBrmyroih4QcuCscvkyzl39O7PjGGSgwka-15ZdHOQvOa8ELyMYH4GtXcheOzkOrikIJcq5FEuVcilCglMxiqi9GlNn5sB22dl3X0EPq-AClr1nVdWm_DMVULkebG8_u3MYdzFo0EvYytoNbbGo55k68xL__gHh5WnzQ</recordid><startdate>20060901</startdate><enddate>20060901</enddate><creator>Hakim, S.G.</creator><creator>Bruecker, C.W.R.</creator><creator>Jacobsen, H.Ch</creator><creator>Hermes, D.</creator><creator>Lauer, I.</creator><creator>Eckerle, S.</creator><creator>Froehlich, A.</creator><creator>Sieg, P.</creator><general>Elsevier Ltd</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20060901</creationdate><title>The value of FDG-PET and bone scintigraphy with SPECT in the primary diagnosis and follow-up of patients with chronic osteomyelitis of the mandible</title><author>Hakim, S.G. ; Bruecker, C.W.R. ; Jacobsen, H.Ch ; Hermes, D. ; Lauer, I. ; Eckerle, S. ; Froehlich, A. ; Sieg, P.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c384t-f8c5b4716813ed6f8e19bc6de2037568405cba9f156845789b0f5d74446415433</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2006</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Bacterial arthritis and osteitis</topic><topic>Bacterial diseases</topic><topic>Biological and medical sciences</topic><topic>Chronic Disease</topic><topic>Dentistry</topic><topic>diagnosis</topic><topic>False Negative Reactions</topic><topic>False Positive Reactions</topic><topic>Fluorodeoxyglucose F18</topic><topic>follow-up</topic><topic>Human bacterial diseases</topic><topic>Humans</topic><topic>Infectious diseases</topic><topic>mandible</topic><topic>Mandible - diagnostic imaging</topic><topic>Mandible - surgery</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>osteomyelitis</topic><topic>Osteomyelitis - diagnostic imaging</topic><topic>Osteomyelitis - surgery</topic><topic>Otorhinolaryngology. Stomatology</topic><topic>PET</topic><topic>Positron-Emission Tomography</topic><topic>Predictive Value of Tests</topic><topic>Prospective Studies</topic><topic>Radiopharmaceuticals</topic><topic>Sensitivity and Specificity</topic><topic>SPECT</topic><topic>Time Factors</topic><topic>Tomography, Emission-Computed, Single-Photon</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Hakim, S.G.</creatorcontrib><creatorcontrib>Bruecker, C.W.R.</creatorcontrib><creatorcontrib>Jacobsen, H.Ch</creatorcontrib><creatorcontrib>Hermes, D.</creatorcontrib><creatorcontrib>Lauer, I.</creatorcontrib><creatorcontrib>Eckerle, S.</creatorcontrib><creatorcontrib>Froehlich, A.</creatorcontrib><creatorcontrib>Sieg, P.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>International journal of oral and maxillofacial surgery</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Hakim, S.G.</au><au>Bruecker, C.W.R.</au><au>Jacobsen, H.Ch</au><au>Hermes, D.</au><au>Lauer, I.</au><au>Eckerle, S.</au><au>Froehlich, A.</au><au>Sieg, P.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The value of FDG-PET and bone scintigraphy with SPECT in the primary diagnosis and follow-up of patients with chronic osteomyelitis of the mandible</atitle><jtitle>International journal of oral and maxillofacial surgery</jtitle><addtitle>Int J Oral Maxillofac Surg</addtitle><date>2006-09-01</date><risdate>2006</risdate><volume>35</volume><issue>9</issue><spage>809</spage><epage>816</epage><pages>809-816</pages><issn>0901-5027</issn><eissn>1399-0020</eissn><coden>IJOSE9</coden><abstract>To appraise the value of FDG-PET and bone scintigraphy using SPECT in the primary diagnosis and follow-up of patients with chronic osteomyelitis of the mandible (COM).
In a prospective study the pattern of tracer uptake was investigated using 2 diagnostic methods in 42 patients. Results were compared with histology and radiographs as well as clinical and laboratory parameters.
The use of FDG-PET in the primary diagnosis of COM resulted in a sensitivity of 64% and a specificity of 77.7%. The sensitivity of SPECT was 84% and the specificity 33.3%.
During the follow-up period of these patients the sensitivity of SPECT increased to 93.7%, while the specificity decreased (6.6%). The sensitivity and specificity of FDG-PET for this follow-up group were 62.5 and 80%, respectively.
Because of its high sensitivity, SPECT is vastly superior to other diagnostic methods in initiating treatment. In the follow-up period it might be replaced by FDG-PET, which reflects the disease course better and indicates the time of clinical remission.</abstract><cop>Amsterdam</cop><pub>Elsevier Ltd</pub><pmid>16829036</pmid><doi>10.1016/j.ijom.2006.03.029</doi><tpages>8</tpages></addata></record> |
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| subjects | Adult Aged Aged, 80 and over Bacterial arthritis and osteitis Bacterial diseases Biological and medical sciences Chronic Disease Dentistry diagnosis False Negative Reactions False Positive Reactions Fluorodeoxyglucose F18 follow-up Human bacterial diseases Humans Infectious diseases mandible Mandible - diagnostic imaging Mandible - surgery Medical sciences Middle Aged osteomyelitis Osteomyelitis - diagnostic imaging Osteomyelitis - surgery Otorhinolaryngology. Stomatology PET Positron-Emission Tomography Predictive Value of Tests Prospective Studies Radiopharmaceuticals Sensitivity and Specificity SPECT Time Factors Tomography, Emission-Computed, Single-Photon |
| title | The value of FDG-PET and bone scintigraphy with SPECT in the primary diagnosis and follow-up of patients with chronic osteomyelitis of the mandible |
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