NudC Is Required for Plk1 Targeting to the Kinetochore and Chromosome Congression

The equal distribution of chromosomes during mitosis is critical for maintaining the integrity of the genome. Essential to this process are the capture of spindle microtubules by kinetochores and the congression of chromosomes to the metaphase plate [1]. Polo-like kinase 1 (Plk1) is a mitotic kinase...

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Veröffentlicht in:	Current biology 2006-07, Vol.16 (14), p.1414-1421
Hauptverfasser:	Nishino, Michiya, Kurasawa, Yasuhiro, Evans, Randall, Lin, Sue-Hwa, Brinkley, Bill R., Yu-Lee, Li-yuan
Format:	Artikel
Sprache:	eng
Schlagworte:	Aspergillus nidulans Cell Cycle Proteins - analysis Cell Cycle Proteins - genetics Cell Cycle Proteins - metabolism Cell Cycle Proteins - physiology CELLBIO Chromosomal Proteins, Non-Histone - metabolism Chromosome Positioning DNA Humans Kinetochores - metabolism Kinetochores - ultrastructure Metaphase - genetics Microtubules - metabolism Models, Biological Mutation Nuclear Proteins - genetics Nuclear Proteins - metabolism Nuclear Proteins - physiology Phosphorylation Polo-Like Kinase 1 Protein Serine-Threonine Kinases - analysis Protein Serine-Threonine Kinases - genetics Protein Serine-Threonine Kinases - metabolism Protein Transport Proto-Oncogene Proteins - analysis Proto-Oncogene Proteins - genetics Proto-Oncogene Proteins - metabolism RNA Interference
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