Role of Korean red ginseng total saponins in rat infertility induced by polycystic ovaries
To investigate the effect of Korean red ginseng total saponins (GTS) on ovarian morphology and nerve growth factor (NGF) expression in the ovaries, pituitary, and hippocampus. Polycystic ovary (PCO) rat model induced by estradiol valerate (EV). University research laboratory. Thirty sexually mature...
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| Veröffentlicht in: | Fertility and sterility 2005-10, Vol.84, p.1139-1143 |
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| creator | Pak, Sok Cheon Lim, Sung Chul Nah, Seung-Yeol Lee, Jiae Hill, Joseph A. Bae, Chun Sik |
| description | To investigate the effect of Korean red ginseng total saponins (GTS) on ovarian morphology and nerve growth factor (NGF) expression in the ovaries, pituitary, and hippocampus.
Polycystic ovary (PCO) rat model induced by estradiol valerate (EV).
University research laboratory.
Thirty sexually mature female Sprague-Dawley rats weighing 190–210 g.
Female Sprague-Dawley rats (190–210 g) were separated into three groups: EV control (n = 10), EV plus GTS (n = 10), and oil control (n = 10).
Ovarian morphology and NGF protein expression.
Polycystic ovary was fully developed in rats with a single intramuscular injection of EV. Increased expression of NGF was noted in the ovaries and the brain of rats with PCO. GTS administration attenuated NGF expression in the ovaries but not in the brain.
Our findings suggest a role for GTS in the regulation of NGF expression in female rats with PCO. |
| doi_str_mv | 10.1016/j.fertnstert.2005.04.042 |
| format | Article |
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Polycystic ovary (PCO) rat model induced by estradiol valerate (EV).
University research laboratory.
Thirty sexually mature female Sprague-Dawley rats weighing 190–210 g.
Female Sprague-Dawley rats (190–210 g) were separated into three groups: EV control (n = 10), EV plus GTS (n = 10), and oil control (n = 10).
Ovarian morphology and NGF protein expression.
Polycystic ovary was fully developed in rats with a single intramuscular injection of EV. Increased expression of NGF was noted in the ovaries and the brain of rats with PCO. GTS administration attenuated NGF expression in the ovaries but not in the brain.
Our findings suggest a role for GTS in the regulation of NGF expression in female rats with PCO.</description><identifier>ISSN: 0015-0282</identifier><identifier>EISSN: 1556-5653</identifier><identifier>DOI: 10.1016/j.fertnstert.2005.04.042</identifier><identifier>PMID: 16210005</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Animals ; Brain - metabolism ; estradiol valerate ; Female ; Ginseng total saponins ; immunohistochemistry ; Infertility, Female - drug therapy ; Infertility, Female - metabolism ; Korea ; nerve growth factor ; Nerve Growth Factor - antagonists & inhibitors ; Nerve Growth Factor - biosynthesis ; Ovary - metabolism ; Panax - chemistry ; polycystic ovary syndrome ; Polycystic Ovary Syndrome - drug therapy ; Polycystic Ovary Syndrome - metabolism ; Rats ; Rats, Sprague-Dawley ; Saponins - pharmacology ; Saponins - therapeutic use</subject><ispartof>Fertility and sterility, 2005-10, Vol.84, p.1139-1143</ispartof><rights>2005 American Society for Reproductive Medicine</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c422t-439285c3c5519677b4b54506fe51d9bc6eb9a65261b12c7c4908d996eb4b86b73</citedby><cites>FETCH-LOGICAL-c422t-439285c3c5519677b4b54506fe51d9bc6eb9a65261b12c7c4908d996eb4b86b73</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.fertnstert.2005.04.042$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3548,27922,27923,45993</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/16210005$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Pak, Sok Cheon</creatorcontrib><creatorcontrib>Lim, Sung Chul</creatorcontrib><creatorcontrib>Nah, Seung-Yeol</creatorcontrib><creatorcontrib>Lee, Jiae</creatorcontrib><creatorcontrib>Hill, Joseph A.</creatorcontrib><creatorcontrib>Bae, Chun Sik</creatorcontrib><title>Role of Korean red ginseng total saponins in rat infertility induced by polycystic ovaries</title><title>Fertility and sterility</title><addtitle>Fertil Steril</addtitle><description>To investigate the effect of Korean red ginseng total saponins (GTS) on ovarian morphology and nerve growth factor (NGF) expression in the ovaries, pituitary, and hippocampus.
Polycystic ovary (PCO) rat model induced by estradiol valerate (EV).
University research laboratory.
Thirty sexually mature female Sprague-Dawley rats weighing 190–210 g.
Female Sprague-Dawley rats (190–210 g) were separated into three groups: EV control (n = 10), EV plus GTS (n = 10), and oil control (n = 10).
Ovarian morphology and NGF protein expression.
Polycystic ovary was fully developed in rats with a single intramuscular injection of EV. Increased expression of NGF was noted in the ovaries and the brain of rats with PCO. GTS administration attenuated NGF expression in the ovaries but not in the brain.
Our findings suggest a role for GTS in the regulation of NGF expression in female rats with PCO.</description><subject>Animals</subject><subject>Brain - metabolism</subject><subject>estradiol valerate</subject><subject>Female</subject><subject>Ginseng total saponins</subject><subject>immunohistochemistry</subject><subject>Infertility, Female - drug therapy</subject><subject>Infertility, Female - metabolism</subject><subject>Korea</subject><subject>nerve growth factor</subject><subject>Nerve Growth Factor - antagonists & inhibitors</subject><subject>Nerve Growth Factor - biosynthesis</subject><subject>Ovary - metabolism</subject><subject>Panax - chemistry</subject><subject>polycystic ovary syndrome</subject><subject>Polycystic Ovary Syndrome - drug therapy</subject><subject>Polycystic Ovary Syndrome - metabolism</subject><subject>Rats</subject><subject>Rats, Sprague-Dawley</subject><subject>Saponins - pharmacology</subject><subject>Saponins - therapeutic use</subject><issn>0015-0282</issn><issn>1556-5653</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2005</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkF9rwyAUxWVsrF23rzB82ls6NdEkj1vZP1YYjO1lL6LmpljS2Kkp5NvP0kIfBxevXs_x4A8hTMmcEiru1_MWfOxDTOucEcLnpEjFztCUci4yLnh-jqaEUJ4RVrEJugphTQgRtGSXaEIFo-nEp-jn03WAXYvfnQfVYw8NXtk-QL_C0UXV4aC2rk8TbNOtiqnts21n45j2zWCSQ49467rRjCFag91OeQvhGl20qgtwc-wz9P389LV4zZYfL2-Lh2VmCsZiVuQ1q7jJDee0FmWpC80LTkQLnDa1NgJ0rQRngmrKTGmKmlRNXadxoSuhy3yG7g7vbr37HSBEubHBQNepHtwQpKiEyGlNk7A6CI13IXho5dbbjfKjpETuucq1PHGVe66SFKlYst4eMwa9geZkPIJMgseDANJPdxa8DMZCn-BYDybKxtn_U_4A9JGPbw</recordid><startdate>20051001</startdate><enddate>20051001</enddate><creator>Pak, Sok Cheon</creator><creator>Lim, Sung Chul</creator><creator>Nah, Seung-Yeol</creator><creator>Lee, Jiae</creator><creator>Hill, Joseph A.</creator><creator>Bae, Chun Sik</creator><general>Elsevier Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20051001</creationdate><title>Role of Korean red ginseng total saponins in rat infertility induced by polycystic ovaries</title><author>Pak, Sok Cheon ; Lim, Sung Chul ; Nah, Seung-Yeol ; Lee, Jiae ; Hill, Joseph A. ; Bae, Chun Sik</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c422t-439285c3c5519677b4b54506fe51d9bc6eb9a65261b12c7c4908d996eb4b86b73</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2005</creationdate><topic>Animals</topic><topic>Brain - metabolism</topic><topic>estradiol valerate</topic><topic>Female</topic><topic>Ginseng total saponins</topic><topic>immunohistochemistry</topic><topic>Infertility, Female - drug therapy</topic><topic>Infertility, Female - metabolism</topic><topic>Korea</topic><topic>nerve growth factor</topic><topic>Nerve Growth Factor - antagonists & inhibitors</topic><topic>Nerve Growth Factor - biosynthesis</topic><topic>Ovary - metabolism</topic><topic>Panax - chemistry</topic><topic>polycystic ovary syndrome</topic><topic>Polycystic Ovary Syndrome - drug therapy</topic><topic>Polycystic Ovary Syndrome - metabolism</topic><topic>Rats</topic><topic>Rats, Sprague-Dawley</topic><topic>Saponins - pharmacology</topic><topic>Saponins - therapeutic use</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Pak, Sok Cheon</creatorcontrib><creatorcontrib>Lim, Sung Chul</creatorcontrib><creatorcontrib>Nah, Seung-Yeol</creatorcontrib><creatorcontrib>Lee, Jiae</creatorcontrib><creatorcontrib>Hill, Joseph A.</creatorcontrib><creatorcontrib>Bae, Chun Sik</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Fertility and sterility</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Pak, Sok Cheon</au><au>Lim, Sung Chul</au><au>Nah, Seung-Yeol</au><au>Lee, Jiae</au><au>Hill, Joseph A.</au><au>Bae, Chun Sik</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Role of Korean red ginseng total saponins in rat infertility induced by polycystic ovaries</atitle><jtitle>Fertility and sterility</jtitle><addtitle>Fertil Steril</addtitle><date>2005-10-01</date><risdate>2005</risdate><volume>84</volume><spage>1139</spage><epage>1143</epage><pages>1139-1143</pages><issn>0015-0282</issn><eissn>1556-5653</eissn><abstract>To investigate the effect of Korean red ginseng total saponins (GTS) on ovarian morphology and nerve growth factor (NGF) expression in the ovaries, pituitary, and hippocampus.
Polycystic ovary (PCO) rat model induced by estradiol valerate (EV).
University research laboratory.
Thirty sexually mature female Sprague-Dawley rats weighing 190–210 g.
Female Sprague-Dawley rats (190–210 g) were separated into three groups: EV control (n = 10), EV plus GTS (n = 10), and oil control (n = 10).
Ovarian morphology and NGF protein expression.
Polycystic ovary was fully developed in rats with a single intramuscular injection of EV. Increased expression of NGF was noted in the ovaries and the brain of rats with PCO. GTS administration attenuated NGF expression in the ovaries but not in the brain.
Our findings suggest a role for GTS in the regulation of NGF expression in female rats with PCO.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>16210005</pmid><doi>10.1016/j.fertnstert.2005.04.042</doi><tpages>5</tpages><oa>free_for_read</oa></addata></record> |
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| source | MEDLINE; ScienceDirect Journals (5 years ago - present); EZB-FREE-00999 freely available EZB journals; Alma/SFX Local Collection |
| subjects | Animals Brain - metabolism estradiol valerate Female Ginseng total saponins immunohistochemistry Infertility, Female - drug therapy Infertility, Female - metabolism Korea nerve growth factor Nerve Growth Factor - antagonists & inhibitors Nerve Growth Factor - biosynthesis Ovary - metabolism Panax - chemistry polycystic ovary syndrome Polycystic Ovary Syndrome - drug therapy Polycystic Ovary Syndrome - metabolism Rats Rats, Sprague-Dawley Saponins - pharmacology Saponins - therapeutic use |
| title | Role of Korean red ginseng total saponins in rat infertility induced by polycystic ovaries |
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