Transient effects of overexpressing anthranilate synthase α and β subunits in Catharanthus roseus hairy roots

Catharanthus roseus produces two economically valuable anticancer drugs, vinblastine and vincristine. These drugs are members of the terpenoid indole alkaloids and accumulate in small quantities within the plant; thus these two drugs are expensive to produce. Metabolic engineering efforts have focus...

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Veröffentlicht in:	Biotechnology progress 2005-09, Vol.21 (5), p.1572-1576
Hauptverfasser:	Peebles, C.A.M, Hong, S.B, Gibson, S.I, Shanks, J.V, San, K.Y
Format:	Artikel
Sprache:	eng
Schlagworte:	anthranilate synthase Anthranilate Synthase - genetics Anthranilate Synthase - metabolism Arabidopsis - enzymology Arabidopsis - genetics Arabidopsis thaliana Biological and medical sciences biosynthesis Biotechnology Catharanthus - genetics Catharanthus - metabolism Catharanthus roseus Fundamental and applied biological sciences. Psychology gene expression Gene Expression Regulation, Plant - physiology gene overexpression Genetic Enhancement - methods genetic transformation indole alkaloids Kinetics Metabolic Clearance Rate Plant Roots - genetics Plant Roots - growth & development Plant Roots - metabolism Plants, Genetically Modified - growth & development Plants, Genetically Modified - metabolism Protein Engineering - methods Protein Subunits Recombinant Proteins - metabolism Rhizobium rhizogenes roots Secologanin Tryptamine Alkaloids - metabolism Time Factors transgenic plants
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