Quantification of voriconazole in plasma by liquid chromatography-tandem mass spectrometry

A convenient liquid chromatography-tandem mass spectrometry method for the quantification of the triazole antifungal agent voriconazole in plasma samples is described. Fenbuconazole is used as an internal standard. After protein precipitation, automated solid-phase extraction is applied. Electrospra...

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Veröffentlicht in:	Clinical chemistry and laboratory medicine 2005-01, Vol.43 (7), p.730-734
Hauptverfasser:	Vogeser, Michael, Schiel, Xaver, Spöhrer, Ute
Format:	Artikel
Sprache:	eng
Schlagworte:	Antifungal Agents - blood Biological and medical sciences Blood Chemical Analysis - instrumentation Blood Chemical Analysis - methods Blood Chemical Analysis - statistics & numerical data Chromatography, Liquid - methods General aspects Humans Investigative techniques, diagnostic techniques (general aspects) liquid chromatography-tandem mass spectrometry Medical sciences Pyrimidines - blood solid phase extraction Spectrometry, Mass, Electrospray Ionization - methods therapeutic drug monitoring Triazoles - blood Voriconazole
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