Effects of Acquired Obesity on Endothelial Function in Monozygotic Twins
OBJECTIVE: To determine whether acquired obesity or accompanying metabolic changes such as adiponectin deficiency, insulin resistance, dyslipidemia, or visceral fat are associated, independent of genetic influences, with endothelial dysfunction by studying young adult monozygotic (MZ) twin pairs dis...
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| Veröffentlicht in: | Obesity (Silver Spring, Md.) Md.), 2006-05, Vol.14 (5), p.826-837 |
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| creator | Pietiläinen, Kirsi H Bergholm, Robert Rissanen, Aila Kaprio, Jaakko Häkkinen, Anna-Maija Sattar, Naveed Yki-Järvinen, Hannele |
| description | OBJECTIVE: To determine whether acquired obesity or accompanying metabolic changes such as adiponectin deficiency, insulin resistance, dyslipidemia, or visceral fat are associated, independent of genetic influences, with endothelial dysfunction by studying young adult monozygotic (MZ) twin pairs discordant for obesity. RESEARCH METHODS AND PROCEDURES: Nine obesity-discordant (intra-pair difference in BMI, 3.8 to 10.1 kg/m²) and nine concordant (0 to 2.3 kg/m²) 24- to 27-year-old MZ twin pairs were identified from a population-based FinnTwin16-sample. Endothelial function was measured by blood flow responses to intrabrachial infusions of an endothelium-dependent (acetylcholine) and an endothelium-independent (sodium nitroprusside) vasodilator. Whole body insulin sensitivity was measured using the euglycemic insulin clamp technique, and forearm and body composition were measured with magnetic resonance imaging and DXA. In addition, serum levels of adiponectin, high-sensitivity C-reactive protein, and lipids were determined. RESULTS: The heavier co-twins of the discordant pairs had significantly lower whole body insulin sensitivity than the leaner co-twins. Blood flows/muscle volume during infusions of acetylcholine and sodium nitroprusside were not altered by obesity. However, intra-pair differences in serum adiponectin, intra-abdominal fat, and C-reactive protein were significantly correlated with those in endothelial function. Only the relationship between intra-pair differences in adiponectin and endothelial function persisted in multiple linear regression analysis. Obesity-concordant co-twins had comparable insulin sensitivity and endothelial function. DISCUSSION: In young adult MZ twins discordant for obesity, acquired adiponectin deficiency rather than obesity per se is an independent correlate of endothelial dysfunction. |
| doi_str_mv | 10.1038/oby.2006.96 |
| format | Article |
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RESEARCH METHODS AND PROCEDURES: Nine obesity-discordant (intra-pair difference in BMI, 3.8 to 10.1 kg/m²) and nine concordant (0 to 2.3 kg/m²) 24- to 27-year-old MZ twin pairs were identified from a population-based FinnTwin16-sample. Endothelial function was measured by blood flow responses to intrabrachial infusions of an endothelium-dependent (acetylcholine) and an endothelium-independent (sodium nitroprusside) vasodilator. Whole body insulin sensitivity was measured using the euglycemic insulin clamp technique, and forearm and body composition were measured with magnetic resonance imaging and DXA. In addition, serum levels of adiponectin, high-sensitivity C-reactive protein, and lipids were determined. RESULTS: The heavier co-twins of the discordant pairs had significantly lower whole body insulin sensitivity than the leaner co-twins. Blood flows/muscle volume during infusions of acetylcholine and sodium nitroprusside were not altered by obesity. However, intra-pair differences in serum adiponectin, intra-abdominal fat, and C-reactive protein were significantly correlated with those in endothelial function. Only the relationship between intra-pair differences in adiponectin and endothelial function persisted in multiple linear regression analysis. Obesity-concordant co-twins had comparable insulin sensitivity and endothelial function. DISCUSSION: In young adult MZ twins discordant for obesity, acquired adiponectin deficiency rather than obesity per se is an independent correlate of endothelial dysfunction.</description><identifier>ISSN: 1071-7323</identifier><identifier>ISSN: 1930-7381</identifier><identifier>EISSN: 1550-8528</identifier><identifier>EISSN: 1930-739X</identifier><identifier>DOI: 10.1038/oby.2006.96</identifier><identifier>PMID: 16855192</identifier><language>eng</language><publisher>Oxford, UK: The North American Association for the Study of Obesity</publisher><subject>abdominal fat ; Acetylcholine - pharmacology ; adiponectin ; Adiponectin - blood ; adipose tissue ; Adult ; adults ; blood flow ; Blood Flow Velocity - drug effects ; blood lipids ; Blood Pressure - physiology ; body composition ; Body Composition - physiology ; Body fat ; Body Mass Index ; C-reactive protein ; C-Reactive Protein - metabolism ; Cholesterol - blood ; Cholesterol, HDL - blood ; Cholesterol, LDL - blood ; cytokines ; Diabetes ; Diseases in Twins - genetics ; Diseases in Twins - physiopathology ; Dose-Response Relationship, Drug ; Endothelium ; Endothelium, Vascular - physiopathology ; environmental factors ; Female ; Forearm - blood supply ; genetic factors ; genetic variation ; Heart Rate - physiology ; hormones ; Hospitals ; Humans ; hyperlipidemia ; insulin ; Insulin resistance ; Insulin Resistance - physiology ; Male ; Metabolic disorders ; monozygotic twins ; muscle ; Nitroprusside - pharmacology ; Obesity ; Obesity - blood ; Obesity - genetics ; Obesity - physiopathology ; Proteins ; Public health ; Regression Analysis ; Research methodology ; Triglycerides - blood ; Twins ; Twins, Monozygotic ; vasodilator agents ; Vasodilator Agents - pharmacology ; visceral fat ; Weight control ; Young adults</subject><ispartof>Obesity (Silver Spring, Md.), 2006-05, Vol.14 (5), p.826-837</ispartof><rights>2006 North American Association for the Study of Obesity (NAASO)</rights><rights>Copyright Nature Publishing Group May 2006</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4400-70e0ffa0a2609a7d1e5b0cc8ed7c4132f06a121c76e4baba696593c7fcbc50fa3</citedby><cites>FETCH-LOGICAL-c4400-70e0ffa0a2609a7d1e5b0cc8ed7c4132f06a121c76e4baba696593c7fcbc50fa3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1038%2Foby.2006.96$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1038%2Foby.2006.96$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1417,1433,27924,27925,45574,45575,46409,46833</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/16855192$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Pietiläinen, Kirsi H</creatorcontrib><creatorcontrib>Bergholm, Robert</creatorcontrib><creatorcontrib>Rissanen, Aila</creatorcontrib><creatorcontrib>Kaprio, Jaakko</creatorcontrib><creatorcontrib>Häkkinen, Anna-Maija</creatorcontrib><creatorcontrib>Sattar, Naveed</creatorcontrib><creatorcontrib>Yki-Järvinen, Hannele</creatorcontrib><title>Effects of Acquired Obesity on Endothelial Function in Monozygotic Twins</title><title>Obesity (Silver Spring, Md.)</title><addtitle>Obesity (Silver Spring)</addtitle><description>OBJECTIVE: To determine whether acquired obesity or accompanying metabolic changes such as adiponectin deficiency, insulin resistance, dyslipidemia, or visceral fat are associated, independent of genetic influences, with endothelial dysfunction by studying young adult monozygotic (MZ) twin pairs discordant for obesity. RESEARCH METHODS AND PROCEDURES: Nine obesity-discordant (intra-pair difference in BMI, 3.8 to 10.1 kg/m²) and nine concordant (0 to 2.3 kg/m²) 24- to 27-year-old MZ twin pairs were identified from a population-based FinnTwin16-sample. Endothelial function was measured by blood flow responses to intrabrachial infusions of an endothelium-dependent (acetylcholine) and an endothelium-independent (sodium nitroprusside) vasodilator. Whole body insulin sensitivity was measured using the euglycemic insulin clamp technique, and forearm and body composition were measured with magnetic resonance imaging and DXA. In addition, serum levels of adiponectin, high-sensitivity C-reactive protein, and lipids were determined. RESULTS: The heavier co-twins of the discordant pairs had significantly lower whole body insulin sensitivity than the leaner co-twins. Blood flows/muscle volume during infusions of acetylcholine and sodium nitroprusside were not altered by obesity. However, intra-pair differences in serum adiponectin, intra-abdominal fat, and C-reactive protein were significantly correlated with those in endothelial function. Only the relationship between intra-pair differences in adiponectin and endothelial function persisted in multiple linear regression analysis. Obesity-concordant co-twins had comparable insulin sensitivity and endothelial function. DISCUSSION: In young adult MZ twins discordant for obesity, acquired adiponectin deficiency rather than obesity per se is an independent correlate of endothelial dysfunction.</description><subject>abdominal fat</subject><subject>Acetylcholine - pharmacology</subject><subject>adiponectin</subject><subject>Adiponectin - blood</subject><subject>adipose tissue</subject><subject>Adult</subject><subject>adults</subject><subject>blood flow</subject><subject>Blood Flow Velocity - drug effects</subject><subject>blood lipids</subject><subject>Blood Pressure - physiology</subject><subject>body composition</subject><subject>Body Composition - physiology</subject><subject>Body fat</subject><subject>Body Mass Index</subject><subject>C-reactive protein</subject><subject>C-Reactive Protein - metabolism</subject><subject>Cholesterol - blood</subject><subject>Cholesterol, HDL - blood</subject><subject>Cholesterol, LDL - blood</subject><subject>cytokines</subject><subject>Diabetes</subject><subject>Diseases in Twins - genetics</subject><subject>Diseases in Twins - physiopathology</subject><subject>Dose-Response Relationship, Drug</subject><subject>Endothelium</subject><subject>Endothelium, Vascular - physiopathology</subject><subject>environmental factors</subject><subject>Female</subject><subject>Forearm - blood supply</subject><subject>genetic factors</subject><subject>genetic variation</subject><subject>Heart Rate - physiology</subject><subject>hormones</subject><subject>Hospitals</subject><subject>Humans</subject><subject>hyperlipidemia</subject><subject>insulin</subject><subject>Insulin resistance</subject><subject>Insulin Resistance - physiology</subject><subject>Male</subject><subject>Metabolic disorders</subject><subject>monozygotic twins</subject><subject>muscle</subject><subject>Nitroprusside - pharmacology</subject><subject>Obesity</subject><subject>Obesity - blood</subject><subject>Obesity - genetics</subject><subject>Obesity - physiopathology</subject><subject>Proteins</subject><subject>Public health</subject><subject>Regression Analysis</subject><subject>Research methodology</subject><subject>Triglycerides - blood</subject><subject>Twins</subject><subject>Twins, Monozygotic</subject><subject>vasodilator agents</subject><subject>Vasodilator Agents - pharmacology</subject><subject>visceral fat</subject><subject>Weight control</subject><subject>Young adults</subject><issn>1071-7323</issn><issn>1930-7381</issn><issn>1550-8528</issn><issn>1930-739X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2006</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp90cFvFCEUBnBiNLZWT951EhMvZrbvwcAwx7bZWpOaPdgePBGGgUozCy3MpBn_ell3o4kHTxDy-x7kg5C3CCsEJk9jv6wogFh14hk5Rs6hlpzK52UPLdYto-yIvMr5HgBFI_ElOUIhOceOHpOrtXPWTLmKrjozj7NPdqg2vc1-WqoYqnUY4vTDjl6P1eUczOTLoQ_V1xjiz-UuTt5UN08-5NfkhdNjtm8O6wm5vVzfXFzV15vPXy7OrmvTNAB1Cxac06CpgE63A1regzHSDq1pkFEHQiNF0wrb9LrXohO8Y6Z1pjccnGYn5ON-7kOKj7PNk9r6bOw46mDjnJWQQoBALPDDP_A-zimUt6lSGzQNp6wp6tNemRRzTtaph-S3Oi0F7ZxUpV61q1d1ouh3h5lzv7XDX3vos4DTPXjyo13-N0ttzr-jhJJ4v08EPc3J_okUupO_Lz0Ip6PSd8lndfuNAjJAkF35XfYL0bqX7w</recordid><startdate>200605</startdate><enddate>200605</enddate><creator>Pietiläinen, Kirsi H</creator><creator>Bergholm, Robert</creator><creator>Rissanen, Aila</creator><creator>Kaprio, Jaakko</creator><creator>Häkkinen, Anna-Maija</creator><creator>Sattar, Naveed</creator><creator>Yki-Järvinen, Hannele</creator><general>The North American Association for the Study of Obesity</general><general>Blackwell Publishing Ltd</general><scope>FBQ</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>K9.</scope><scope>7X8</scope></search><sort><creationdate>200605</creationdate><title>Effects of Acquired Obesity on Endothelial Function in Monozygotic Twins</title><author>Pietiläinen, Kirsi H ; Bergholm, Robert ; Rissanen, Aila ; Kaprio, Jaakko ; Häkkinen, Anna-Maija ; Sattar, Naveed ; Yki-Järvinen, Hannele</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4400-70e0ffa0a2609a7d1e5b0cc8ed7c4132f06a121c76e4baba696593c7fcbc50fa3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2006</creationdate><topic>abdominal fat</topic><topic>Acetylcholine - pharmacology</topic><topic>adiponectin</topic><topic>Adiponectin - blood</topic><topic>adipose tissue</topic><topic>Adult</topic><topic>adults</topic><topic>blood flow</topic><topic>Blood Flow Velocity - drug effects</topic><topic>blood lipids</topic><topic>Blood Pressure - physiology</topic><topic>body composition</topic><topic>Body Composition - physiology</topic><topic>Body fat</topic><topic>Body Mass Index</topic><topic>C-reactive protein</topic><topic>C-Reactive Protein - metabolism</topic><topic>Cholesterol - blood</topic><topic>Cholesterol, HDL - blood</topic><topic>Cholesterol, LDL - blood</topic><topic>cytokines</topic><topic>Diabetes</topic><topic>Diseases in Twins - genetics</topic><topic>Diseases in Twins - physiopathology</topic><topic>Dose-Response Relationship, Drug</topic><topic>Endothelium</topic><topic>Endothelium, Vascular - physiopathology</topic><topic>environmental factors</topic><topic>Female</topic><topic>Forearm - blood supply</topic><topic>genetic factors</topic><topic>genetic variation</topic><topic>Heart Rate - physiology</topic><topic>hormones</topic><topic>Hospitals</topic><topic>Humans</topic><topic>hyperlipidemia</topic><topic>insulin</topic><topic>Insulin resistance</topic><topic>Insulin Resistance - physiology</topic><topic>Male</topic><topic>Metabolic disorders</topic><topic>monozygotic twins</topic><topic>muscle</topic><topic>Nitroprusside - pharmacology</topic><topic>Obesity</topic><topic>Obesity - blood</topic><topic>Obesity - genetics</topic><topic>Obesity - physiopathology</topic><topic>Proteins</topic><topic>Public health</topic><topic>Regression Analysis</topic><topic>Research methodology</topic><topic>Triglycerides - blood</topic><topic>Twins</topic><topic>Twins, Monozygotic</topic><topic>vasodilator agents</topic><topic>Vasodilator Agents - pharmacology</topic><topic>visceral fat</topic><topic>Weight control</topic><topic>Young adults</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Pietiläinen, Kirsi H</creatorcontrib><creatorcontrib>Bergholm, Robert</creatorcontrib><creatorcontrib>Rissanen, Aila</creatorcontrib><creatorcontrib>Kaprio, Jaakko</creatorcontrib><creatorcontrib>Häkkinen, Anna-Maija</creatorcontrib><creatorcontrib>Sattar, Naveed</creatorcontrib><creatorcontrib>Yki-Järvinen, Hannele</creatorcontrib><collection>AGRIS</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><jtitle>Obesity (Silver Spring, Md.)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Pietiläinen, Kirsi H</au><au>Bergholm, Robert</au><au>Rissanen, Aila</au><au>Kaprio, Jaakko</au><au>Häkkinen, Anna-Maija</au><au>Sattar, Naveed</au><au>Yki-Järvinen, Hannele</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effects of Acquired Obesity on Endothelial Function in Monozygotic Twins</atitle><jtitle>Obesity (Silver Spring, Md.)</jtitle><addtitle>Obesity (Silver Spring)</addtitle><date>2006-05</date><risdate>2006</risdate><volume>14</volume><issue>5</issue><spage>826</spage><epage>837</epage><pages>826-837</pages><issn>1071-7323</issn><issn>1930-7381</issn><eissn>1550-8528</eissn><eissn>1930-739X</eissn><abstract>OBJECTIVE: To determine whether acquired obesity or accompanying metabolic changes such as adiponectin deficiency, insulin resistance, dyslipidemia, or visceral fat are associated, independent of genetic influences, with endothelial dysfunction by studying young adult monozygotic (MZ) twin pairs discordant for obesity. RESEARCH METHODS AND PROCEDURES: Nine obesity-discordant (intra-pair difference in BMI, 3.8 to 10.1 kg/m²) and nine concordant (0 to 2.3 kg/m²) 24- to 27-year-old MZ twin pairs were identified from a population-based FinnTwin16-sample. Endothelial function was measured by blood flow responses to intrabrachial infusions of an endothelium-dependent (acetylcholine) and an endothelium-independent (sodium nitroprusside) vasodilator. Whole body insulin sensitivity was measured using the euglycemic insulin clamp technique, and forearm and body composition were measured with magnetic resonance imaging and DXA. In addition, serum levels of adiponectin, high-sensitivity C-reactive protein, and lipids were determined. RESULTS: The heavier co-twins of the discordant pairs had significantly lower whole body insulin sensitivity than the leaner co-twins. Blood flows/muscle volume during infusions of acetylcholine and sodium nitroprusside were not altered by obesity. However, intra-pair differences in serum adiponectin, intra-abdominal fat, and C-reactive protein were significantly correlated with those in endothelial function. Only the relationship between intra-pair differences in adiponectin and endothelial function persisted in multiple linear regression analysis. Obesity-concordant co-twins had comparable insulin sensitivity and endothelial function. DISCUSSION: In young adult MZ twins discordant for obesity, acquired adiponectin deficiency rather than obesity per se is an independent correlate of endothelial dysfunction.</abstract><cop>Oxford, UK</cop><pub>The North American Association for the Study of Obesity</pub><pmid>16855192</pmid><doi>10.1038/oby.2006.96</doi><tpages>12</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | abdominal fat Acetylcholine - pharmacology adiponectin Adiponectin - blood adipose tissue Adult adults blood flow Blood Flow Velocity - drug effects blood lipids Blood Pressure - physiology body composition Body Composition - physiology Body fat Body Mass Index C-reactive protein C-Reactive Protein - metabolism Cholesterol - blood Cholesterol, HDL - blood Cholesterol, LDL - blood cytokines Diabetes Diseases in Twins - genetics Diseases in Twins - physiopathology Dose-Response Relationship, Drug Endothelium Endothelium, Vascular - physiopathology environmental factors Female Forearm - blood supply genetic factors genetic variation Heart Rate - physiology hormones Hospitals Humans hyperlipidemia insulin Insulin resistance Insulin Resistance - physiology Male Metabolic disorders monozygotic twins muscle Nitroprusside - pharmacology Obesity Obesity - blood Obesity - genetics Obesity - physiopathology Proteins Public health Regression Analysis Research methodology Triglycerides - blood Twins Twins, Monozygotic vasodilator agents Vasodilator Agents - pharmacology visceral fat Weight control Young adults |
| title | Effects of Acquired Obesity on Endothelial Function in Monozygotic Twins |
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