A concise total synthesis of salinosporamide A

A concise and straightforward 14-step total synthesis of (+/-)-salinosporamide A, based on a diastereoselective acid-catalysed intramolecular cyclisation of to the pyrrolidinone , and a regioselective reduction of the malonate derivative 8b to the aldehyde 9, is described.

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Bibliographische Detailangaben
Veröffentlicht in:	Organic & biomolecular chemistry 2006-08, Vol.4 (15), p.2845-2846
Hauptverfasser:	Mulholland, Nicholas P, Pattenden, Gerald, Walters, Iain A S
Format:	Artikel
Sprache:	eng
Schlagworte:	Cyclization Lactones - chemical synthesis Protease Inhibitors - chemical synthesis Proteasome Inhibitors Pyrroles - chemical synthesis
Online-Zugang:	Volltext
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Beschreibung
Zusammenfassung:	A concise and straightforward 14-step total synthesis of (+/-)-salinosporamide A, based on a diastereoselective acid-catalysed intramolecular cyclisation of to the pyrrolidinone , and a regioselective reduction of the malonate derivative 8b to the aldehyde 9, is described.
ISSN:	1477-0520 1477-0539
DOI:	10.1039/b607109k