At what level of unilateral renal impairment does contralateral functional compensation occur?
Functional compensation occurs in a kidney when the function of the contralateral kidney is decreased or absent. What is, however, not documented is the level of unilateral renal impairment at which functional compensation occurs. Split function, as obtained from a radionuclide renogram, can only sh...
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| Veröffentlicht in: | Pediatric nephrology (Berlin, West) West), 2005-11, Vol.20 (11), p.1593-1598 |
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| creator | Piepsz, Amy Prigent, Alain Hall, Michèle Ismaili, Khalid Collier, Frank Ham, Hamphrey |
| description | Functional compensation occurs in a kidney when the function of the contralateral kidney is decreased or absent. What is, however, not documented is the level of unilateral renal impairment at which functional compensation occurs. Split function, as obtained from a radionuclide renogram, can only show the asymmetry between both kidneys. The aim of the present work was to evaluate at what level of unilateral impairment a functional compensation can be observed in the contralateral normal kidney. From a large database, 180 children over 2 years of age with unilateral pathology were retrospectively selected. All of them underwent a radionuclide study, combining a technetium-99m mercaptoacetyltriglycine (Tc-99m MAG3) renogram associated with a chromium-51 ethylenediaminetetraacetic acid (Cr-51 EDTA) overall clearance, allowing a precise estimation of single-kidney glomerular filtration rate (SKGFR). Below 30-35 ml/min/1.73 m2, there was a significant inverse correlation between SKGFR on the normal and the abnormal side. Above this level, no such correlation was observed, the mean SKGFR on the normal side remaining around 58 ml/min/1.73 m2, whatever the value of SKGFR on the abnormal side. In pediatric patients, hyperfunction occurs when SKGFR of the diseased kidney is below 30-35 ml/min/1.73 m2. |
| doi_str_mv | 10.1007/s00467-005-1974-x |
| format | Article |
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What is, however, not documented is the level of unilateral renal impairment at which functional compensation occurs. Split function, as obtained from a radionuclide renogram, can only show the asymmetry between both kidneys. The aim of the present work was to evaluate at what level of unilateral impairment a functional compensation can be observed in the contralateral normal kidney. From a large database, 180 children over 2 years of age with unilateral pathology were retrospectively selected. All of them underwent a radionuclide study, combining a technetium-99m mercaptoacetyltriglycine (Tc-99m MAG3) renogram associated with a chromium-51 ethylenediaminetetraacetic acid (Cr-51 EDTA) overall clearance, allowing a precise estimation of single-kidney glomerular filtration rate (SKGFR). Below 30-35 ml/min/1.73 m2, there was a significant inverse correlation between SKGFR on the normal and the abnormal side. Above this level, no such correlation was observed, the mean SKGFR on the normal side remaining around 58 ml/min/1.73 m2, whatever the value of SKGFR on the abnormal side. In pediatric patients, hyperfunction occurs when SKGFR of the diseased kidney is below 30-35 ml/min/1.73 m2.</description><identifier>ISSN: 0931-041X</identifier><identifier>EISSN: 1432-198X</identifier><identifier>DOI: 10.1007/s00467-005-1974-x</identifier><identifier>PMID: 16079984</identifier><language>eng</language><publisher>Germany: Springer</publisher><subject>Adaptation, Physiological ; Adolescent ; Adult ; Child ; Child, Preschool ; Children ; Drug dosages ; Glomerular Filtration Rate ; Health aspects ; Humans ; Kidney - diagnostic imaging ; Kidney - physiopathology ; Kidney diseases ; Kidney Diseases - diagnostic imaging ; Kidney Diseases - physiopathology ; Kidneys ; Nuclear medicine ; Pathology ; Patients ; Pediatrics ; Radioisotope Renography</subject><ispartof>Pediatric nephrology (Berlin, West), 2005-11, Vol.20 (11), p.1593-1598</ispartof><rights>COPYRIGHT 2005 Springer</rights><rights>IPNA 2005</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c357t-52d434836490384cf914410b61c78cc0db4dd53616e2f9756773adad80d0a4353</citedby><cites>FETCH-LOGICAL-c357t-52d434836490384cf914410b61c78cc0db4dd53616e2f9756773adad80d0a4353</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/16079984$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Piepsz, Amy</creatorcontrib><creatorcontrib>Prigent, Alain</creatorcontrib><creatorcontrib>Hall, Michèle</creatorcontrib><creatorcontrib>Ismaili, Khalid</creatorcontrib><creatorcontrib>Collier, Frank</creatorcontrib><creatorcontrib>Ham, Hamphrey</creatorcontrib><title>At what level of unilateral renal impairment does contralateral functional compensation occur?</title><title>Pediatric nephrology (Berlin, West)</title><addtitle>Pediatr Nephrol</addtitle><description>Functional compensation occurs in a kidney when the function of the contralateral kidney is decreased or absent. What is, however, not documented is the level of unilateral renal impairment at which functional compensation occurs. Split function, as obtained from a radionuclide renogram, can only show the asymmetry between both kidneys. The aim of the present work was to evaluate at what level of unilateral impairment a functional compensation can be observed in the contralateral normal kidney. From a large database, 180 children over 2 years of age with unilateral pathology were retrospectively selected. All of them underwent a radionuclide study, combining a technetium-99m mercaptoacetyltriglycine (Tc-99m MAG3) renogram associated with a chromium-51 ethylenediaminetetraacetic acid (Cr-51 EDTA) overall clearance, allowing a precise estimation of single-kidney glomerular filtration rate (SKGFR). Below 30-35 ml/min/1.73 m2, there was a significant inverse correlation between SKGFR on the normal and the abnormal side. 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In pediatric patients, hyperfunction occurs when SKGFR of the diseased kidney is below 30-35 ml/min/1.73 m2.</description><subject>Adaptation, Physiological</subject><subject>Adolescent</subject><subject>Adult</subject><subject>Child</subject><subject>Child, Preschool</subject><subject>Children</subject><subject>Drug dosages</subject><subject>Glomerular Filtration Rate</subject><subject>Health aspects</subject><subject>Humans</subject><subject>Kidney - diagnostic imaging</subject><subject>Kidney - physiopathology</subject><subject>Kidney diseases</subject><subject>Kidney Diseases - diagnostic imaging</subject><subject>Kidney Diseases - physiopathology</subject><subject>Kidneys</subject><subject>Nuclear medicine</subject><subject>Pathology</subject><subject>Patients</subject><subject>Pediatrics</subject><subject>Radioisotope Renography</subject><issn>0931-041X</issn><issn>1432-198X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2005</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNpdkc9rFTEQx4Mo9ln9A7zI4qG31Zn83pM8irWFghcLPRnykqxvS3bzTLLa_vfu8h4UvMww5DNfJnwIeY_wCQHU5wLApWoBRIud4u3jC7JBzugy6fuXZAMdwxY43p-RN6U8AIAWWr4mZyhBdZ3mG_JzW5u_e1ubGP6E2KS-mach2hqyjU0O01KH8WCHPIapNj6F0rg01eX1xPTz5OqQVtCl8RCmYtexSc7N-ctb8qq3sYR3p35O7q6-_ri8bm-_f7u53N62jglVW0E9Z1wzyTtgmru-Q84RdhKd0s6B33HvBZMoA-07JaRSzHrrNXiwnAl2Ti6OuYecfs-hVDMOxYUY7RTSXIzUUmgm6AJ-_A98SHNeri-GUso0IsrntF82BrMPNtZ9SXFeP1bMFgXVinZ0TcMj6HIqJYfeHPIw2vxkEMyqyBwVmUWRWRWZx2Xnw-mCeTcG_7xxcsL-AeqGjAI</recordid><startdate>200511</startdate><enddate>200511</enddate><creator>Piepsz, Amy</creator><creator>Prigent, Alain</creator><creator>Hall, Michèle</creator><creator>Ismaili, Khalid</creator><creator>Collier, Frank</creator><creator>Ham, Hamphrey</creator><general>Springer</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QP</scope><scope>7RV</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9-</scope><scope>K9.</scope><scope>KB0</scope><scope>M0R</scope><scope>M0S</scope><scope>M1P</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope></search><sort><creationdate>200511</creationdate><title>At what level of unilateral renal impairment does contralateral functional compensation occur?</title><author>Piepsz, Amy ; 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What is, however, not documented is the level of unilateral renal impairment at which functional compensation occurs. Split function, as obtained from a radionuclide renogram, can only show the asymmetry between both kidneys. The aim of the present work was to evaluate at what level of unilateral impairment a functional compensation can be observed in the contralateral normal kidney. From a large database, 180 children over 2 years of age with unilateral pathology were retrospectively selected. All of them underwent a radionuclide study, combining a technetium-99m mercaptoacetyltriglycine (Tc-99m MAG3) renogram associated with a chromium-51 ethylenediaminetetraacetic acid (Cr-51 EDTA) overall clearance, allowing a precise estimation of single-kidney glomerular filtration rate (SKGFR). Below 30-35 ml/min/1.73 m2, there was a significant inverse correlation between SKGFR on the normal and the abnormal side. 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| subjects | Adaptation, Physiological Adolescent Adult Child Child, Preschool Children Drug dosages Glomerular Filtration Rate Health aspects Humans Kidney - diagnostic imaging Kidney - physiopathology Kidney diseases Kidney Diseases - diagnostic imaging Kidney Diseases - physiopathology Kidneys Nuclear medicine Pathology Patients Pediatrics Radioisotope Renography |
| title | At what level of unilateral renal impairment does contralateral functional compensation occur? |
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