Atrophic dermatofibrosarcoma protuberans with diffuse eosinophilic infiltrate
ABSTRACT Atrophic dermatofibrosarcoma protuberans (atrophic DFSP) is a variant of dermatofibrosarcoma protuberans (DFSP), and is clinically characterized by depressed lesions. We report a patient with a typical atrophic DFSP lesion with marked eosinophilic infiltration. The patient was a 55‐year‐old...
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| Veröffentlicht in: | Journal of dermatology 2006-07, Vol.33 (7), p.486-488 |
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| container_title | Journal of dermatology |
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| creator | HIRASHIMA, Noriyuki MISAGO, Noriyuki SHINOGI, Taro INOUE, Takuya MIURA, Yoshihiro NARISAWA, Yutaka |
| description | ABSTRACT
Atrophic dermatofibrosarcoma protuberans (atrophic DFSP) is a variant of dermatofibrosarcoma protuberans (DFSP), and is clinically characterized by depressed lesions. We report a patient with a typical atrophic DFSP lesion with marked eosinophilic infiltration. The patient was a 55‐year‐old woman with a dark‐red, depressed lesion in the epigastric region. Histopathological examination of the lesion showed proliferation of fibroblast‐like cells in a storiform pattern in the dermis and subcutaneous tissue. Immunohistochemical staining of tumor cells was positive for CD34. The lesion was histopathologically typical of DFSP, but no elevated lesion was clinically observed. Thus, a diagnosis of atrophic DFSP was made. Moreover, this tumor tissue exhibited marked eosinophilic infiltration. To our knowledge, they are no reports of eosinophilic infiltration in DFSP tissue. Therefore, this seems to be an extremely rare case of DFSP. |
| doi_str_mv | 10.1111/j.1346-8138.2006.00114.x |
| format | Article |
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Atrophic dermatofibrosarcoma protuberans (atrophic DFSP) is a variant of dermatofibrosarcoma protuberans (DFSP), and is clinically characterized by depressed lesions. We report a patient with a typical atrophic DFSP lesion with marked eosinophilic infiltration. The patient was a 55‐year‐old woman with a dark‐red, depressed lesion in the epigastric region. Histopathological examination of the lesion showed proliferation of fibroblast‐like cells in a storiform pattern in the dermis and subcutaneous tissue. Immunohistochemical staining of tumor cells was positive for CD34. The lesion was histopathologically typical of DFSP, but no elevated lesion was clinically observed. Thus, a diagnosis of atrophic DFSP was made. Moreover, this tumor tissue exhibited marked eosinophilic infiltration. To our knowledge, they are no reports of eosinophilic infiltration in DFSP tissue. Therefore, this seems to be an extremely rare case of DFSP.</description><identifier>ISSN: 0385-2407</identifier><identifier>EISSN: 1346-8138</identifier><identifier>DOI: 10.1111/j.1346-8138.2006.00114.x</identifier><identifier>PMID: 16848822</identifier><language>eng</language><publisher>Melbourne, Australia: Blackwell Publishing Asia</publisher><subject>atrophic dermatofibrosarcoma protuberans ; Dermatofibrosarcoma - pathology ; Eosinophilia - pathology ; eosinophilic infiltration ; Female ; Humans ; Middle Aged ; Skin Neoplasms - pathology</subject><ispartof>Journal of dermatology, 2006-07, Vol.33 (7), p.486-488</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4634-b60e8b3f36349ebde6d3010289a23d506817abe1f615a05235ffc94c841c6bf43</citedby><cites>FETCH-LOGICAL-c4634-b60e8b3f36349ebde6d3010289a23d506817abe1f615a05235ffc94c841c6bf43</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fj.1346-8138.2006.00114.x$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fj.1346-8138.2006.00114.x$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1417,27924,27925,45574,45575</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/16848822$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>HIRASHIMA, Noriyuki</creatorcontrib><creatorcontrib>MISAGO, Noriyuki</creatorcontrib><creatorcontrib>SHINOGI, Taro</creatorcontrib><creatorcontrib>INOUE, Takuya</creatorcontrib><creatorcontrib>MIURA, Yoshihiro</creatorcontrib><creatorcontrib>NARISAWA, Yutaka</creatorcontrib><title>Atrophic dermatofibrosarcoma protuberans with diffuse eosinophilic infiltrate</title><title>Journal of dermatology</title><addtitle>J Dermatol</addtitle><description>ABSTRACT
Atrophic dermatofibrosarcoma protuberans (atrophic DFSP) is a variant of dermatofibrosarcoma protuberans (DFSP), and is clinically characterized by depressed lesions. We report a patient with a typical atrophic DFSP lesion with marked eosinophilic infiltration. The patient was a 55‐year‐old woman with a dark‐red, depressed lesion in the epigastric region. Histopathological examination of the lesion showed proliferation of fibroblast‐like cells in a storiform pattern in the dermis and subcutaneous tissue. Immunohistochemical staining of tumor cells was positive for CD34. The lesion was histopathologically typical of DFSP, but no elevated lesion was clinically observed. Thus, a diagnosis of atrophic DFSP was made. Moreover, this tumor tissue exhibited marked eosinophilic infiltration. To our knowledge, they are no reports of eosinophilic infiltration in DFSP tissue. Therefore, this seems to be an extremely rare case of DFSP.</description><subject>atrophic dermatofibrosarcoma protuberans</subject><subject>Dermatofibrosarcoma - pathology</subject><subject>Eosinophilia - pathology</subject><subject>eosinophilic infiltration</subject><subject>Female</subject><subject>Humans</subject><subject>Middle Aged</subject><subject>Skin Neoplasms - pathology</subject><issn>0385-2407</issn><issn>1346-8138</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2006</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkE1PwzAMhiMEYmPwF1BP3Fqcj2apxGUa40tDXOAcJW2iZWrXkbRi-_ekbIIrvtiW39dOHoQSDBmOcbvOMGU8FZiKjADwDABjlu1O0Ph3cIrGQEWeEgbTEboIYQ1AihzDORphLpgQhIzR66zz7XblyqQyvlFda532bVC-bBuVbH3b9dp4tQnJl-tWSeWs7YNJTBvcZvDV0ek21tWdV525RGdW1cFcHfMEfTws3udP6fLt8Xk-W6Yl45SlmoMRmloam8LoyvCKAgYiCkVolQMXeKq0wZbjXEFOaG5tWbBSMFxybRmdoJvD3vjAz96ETjYulKau1ca0fZBc8FwQVkShOAjL-KngjZVb7xrl9xKDHFDKtRyIyYGYHFDKH5RyF63Xxxu9bkz1Zzyyi4K7g-DL1Wb_78Xy5X4RC_oN4jCDIg</recordid><startdate>200607</startdate><enddate>200607</enddate><creator>HIRASHIMA, Noriyuki</creator><creator>MISAGO, Noriyuki</creator><creator>SHINOGI, Taro</creator><creator>INOUE, Takuya</creator><creator>MIURA, Yoshihiro</creator><creator>NARISAWA, Yutaka</creator><general>Blackwell Publishing Asia</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>200607</creationdate><title>Atrophic dermatofibrosarcoma protuberans with diffuse eosinophilic infiltrate</title><author>HIRASHIMA, Noriyuki ; MISAGO, Noriyuki ; SHINOGI, Taro ; INOUE, Takuya ; MIURA, Yoshihiro ; NARISAWA, Yutaka</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4634-b60e8b3f36349ebde6d3010289a23d506817abe1f615a05235ffc94c841c6bf43</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2006</creationdate><topic>atrophic dermatofibrosarcoma protuberans</topic><topic>Dermatofibrosarcoma - pathology</topic><topic>Eosinophilia - pathology</topic><topic>eosinophilic infiltration</topic><topic>Female</topic><topic>Humans</topic><topic>Middle Aged</topic><topic>Skin Neoplasms - pathology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>HIRASHIMA, Noriyuki</creatorcontrib><creatorcontrib>MISAGO, Noriyuki</creatorcontrib><creatorcontrib>SHINOGI, Taro</creatorcontrib><creatorcontrib>INOUE, Takuya</creatorcontrib><creatorcontrib>MIURA, Yoshihiro</creatorcontrib><creatorcontrib>NARISAWA, Yutaka</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of dermatology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>HIRASHIMA, Noriyuki</au><au>MISAGO, Noriyuki</au><au>SHINOGI, Taro</au><au>INOUE, Takuya</au><au>MIURA, Yoshihiro</au><au>NARISAWA, Yutaka</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Atrophic dermatofibrosarcoma protuberans with diffuse eosinophilic infiltrate</atitle><jtitle>Journal of dermatology</jtitle><addtitle>J Dermatol</addtitle><date>2006-07</date><risdate>2006</risdate><volume>33</volume><issue>7</issue><spage>486</spage><epage>488</epage><pages>486-488</pages><issn>0385-2407</issn><eissn>1346-8138</eissn><abstract>ABSTRACT
Atrophic dermatofibrosarcoma protuberans (atrophic DFSP) is a variant of dermatofibrosarcoma protuberans (DFSP), and is clinically characterized by depressed lesions. We report a patient with a typical atrophic DFSP lesion with marked eosinophilic infiltration. The patient was a 55‐year‐old woman with a dark‐red, depressed lesion in the epigastric region. Histopathological examination of the lesion showed proliferation of fibroblast‐like cells in a storiform pattern in the dermis and subcutaneous tissue. Immunohistochemical staining of tumor cells was positive for CD34. The lesion was histopathologically typical of DFSP, but no elevated lesion was clinically observed. Thus, a diagnosis of atrophic DFSP was made. Moreover, this tumor tissue exhibited marked eosinophilic infiltration. To our knowledge, they are no reports of eosinophilic infiltration in DFSP tissue. Therefore, this seems to be an extremely rare case of DFSP.</abstract><cop>Melbourne, Australia</cop><pub>Blackwell Publishing Asia</pub><pmid>16848822</pmid><doi>10.1111/j.1346-8138.2006.00114.x</doi><tpages>3</tpages></addata></record> |
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| subjects | atrophic dermatofibrosarcoma protuberans Dermatofibrosarcoma - pathology Eosinophilia - pathology eosinophilic infiltration Female Humans Middle Aged Skin Neoplasms - pathology |
| title | Atrophic dermatofibrosarcoma protuberans with diffuse eosinophilic infiltrate |
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