Programming of GnRH feedback controls timing puberty and adult reproductive activity

The timing of puberty generally differs between sexes, and this may be due to sex differences in the organization of steroid feedback systems. We propose that the reproductive neuroendocrine default sex is female. If the individual is male, the feedback control of GnRH secretion is programmed early...

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Veröffentlicht in:	Molecular and cellular endocrinology 2006-07, Vol.254, p.109-119
Hauptverfasser:	Foster, Douglas L., Jackson, Leslie M., Padmanabhan, Vasantha
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological Clocks - physiology Developmental programming Feedback, Physiological - physiology Female GnRH Gonadal Steroid Hormones - physiology Gonadotropin-Releasing Hormone - physiology Gonadotropin-Releasing Hormone - secretion Humans Male Models, Biological Nervous System Malformations - complications Neurons - secretion Puberty Puberty - physiology Pulsatile Flow - physiology Reproduction - physiology Sex Characteristics Sexual Development Sexual differentiation Sheep Time
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