Differential Immunogenicity of HIV‐1 Clade C Proteins in Eliciting CD8+ and CD4+ Cell Responses

Background. The relative immunogenicity of human immunodeficiency virus type 1 (HIV‐1) proteins for CD8+ and CD4+ cell responses has not been defined. Methods. HIV‐1–specific T cell responses were evaluated in 65 chronically HIV‐1–infected untreated subjects by interferon‐γ flow cytometry with pepti...

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Veröffentlicht in:	The Journal of infectious diseases 2005-11, Vol.192 (9), p.1588-1596
Hauptverfasser:	Ramduth, Danni , Chetty, Polan , Mngquandaniso, Nolwandle Cyloria , Nene, Nonhlanhla , Harlow, Jason Davis , Honeyborne, Isobella , Ntumba, Nelisiwe , Gappoo, Sharika , Henry, Chiara , Jeena, Prakash , Addo, Marylyn Martina , Altfeld, Marcus , Brander, Christian , Day, Cheryl , Coovadia, Hoosen , Kiepiela, Photini , Goulder, Philip , Walker, Bruce
Format:	Artikel
Sprache:	eng
Schlagworte:	CD4-Positive T-Lymphocytes - immunology CD8-Positive T-Lymphocytes - immunology Chronic Disease Female Gene Products, gag - immunology HIV Infections - immunology HIV Infections - virology HIV-1 - classification HIV-1 - immunology Humans Lymphocyte Count Male Proteome - immunology Viral Load Viral Proteins - immunology
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