The Influence of the Sennosides on Absorption of Glycyrrhetic Acid in Rats

In the course of our clinical studies of Kampo medicine (traditional Japanese medicines), we observed the pharmacokinetic interactions between two herbs. When Onpito (TJ-8117, Kampo medicine) containing licorice and rhubarb was administered orally to human subjects, we observed that the AUC(0—lim) a...

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Veröffentlicht in:	Biological & Pharmaceutical Bulletin 2005, Vol.28(10), pp.1897-1902
Hauptverfasser:	Mizuhara, Yasuharu, Takizawa, Yukiho, Ishihara, Kazuhisa, Asano, Takayuki, Kushida, Hirotaka, Morota, Takashi, Kase, Yoshio, Takeda, Shuichi, Aburada, Masaki, Nomura, Masaaki, Yokogawa, Koichi
Format:	Artikel
Sprache:	eng
Schlagworte:	absorption Animals Anthraquinones - pharmacology Area Under Curve Chromatography, High Pressure Liquid glycyrrhetic acid Glycyrrhetinic Acid - analysis Glycyrrhetinic Acid - blood Glycyrrhetinic Acid - pharmacokinetics Immunoenzyme Techniques interaction Intestinal Absorption Intestines - microbiology licorice Male Rats Rats, Sprague-Dawley rhein rhubarb Senna Extract
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