In vivo measurement of brain monoamine oxidase B occupancy by rasagiline, using (11)C-l-deprenyl and PET

In recent years, monoamine oxidase B (MAO-B) inhibitors have become widely used in the treatment of early-stage Parkinson's disease. (11)C-l-deprenyl PET has been used by others to characterize MAO-B ligands in terms of their in vivo potency toward MAO-B and duration of action. In this study, w...

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Veröffentlicht in:	The Journal of nuclear medicine (1978) 2005-10, Vol.46 (10), p.1618-1624
Hauptverfasser:	Freedman, Nanette M T, Mishani, Eyal, Krausz, Yodphat, Weininger, Jolie, Lester, Hava, Blaugrund, Eran, Ehrlich, Daphna, Chisin, Roland
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Brain - diagnostic imaging Brain - drug effects Brain - metabolism Humans Indans - pharmacology Male Metabolic Clearance Rate - drug effects Monoamine Oxidase - metabolism Monoamine Oxidase Inhibitors - pharmacology Positron-Emission Tomography - methods Radiopharmaceuticals - pharmacokinetics Selegiline - pharmacokinetics Tissue Distribution
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