Targeted elimination of prostate cancer by genetically directed human T lymphocytes

The genetic transfer of antigen receptors is a powerful approach to rapidly generate tumor-specific T lymphocytes. Unlike the physiologic T-cell receptor, chimeric antigen receptors (CARs) encompass immunoglobulin variable regions or receptor ligands as their antigen recognition moiety, thus permitt...

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Veröffentlicht in:	Cancer research (Chicago, Ill.) Ill.), 2005-10, Vol.65 (19), p.9080-9088
Hauptverfasser:	GADE, Terence P. F, HASSEN, Waleed, LYDDANE, Clay, OSBORNE, Joseph R, BUCHANAN, Ian M, HALL, Simon J, HESTON, Warren D, RIVIERE, Isabelle, LARSON, Steven M, KOUTCHER, Jason A, SADELAIN, Michel, SANTOS, Elmer, GUNSET, Gertrude, SAUDEMONT, Aurore, GONG, Michael C, BRENTJENS, Renier, ZHONG, Xiao-Song, STEPHAN, Matthias, STEFANSKI, Jolanta
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antigens, Surface - genetics Antigens, Surface - immunology Antineoplastic agents Biological and medical sciences Cell Line, Tumor Epitopes, T-Lymphocyte - genetics Epitopes, T-Lymphocyte - immunology General aspects Glutamate Carboxypeptidase II - genetics Glutamate Carboxypeptidase II - immunology Gynecology. Andrology. Obstetrics Humans Immunologic Memory - immunology Immunotherapy, Adoptive - methods Lung Neoplasms - immunology Lung Neoplasms - secondary Lung Neoplasms - therapy Lymphocyte Activation Male Male genital diseases Medical sciences Membrane Proteins - genetics Membrane Proteins - immunology Mice Mice, SCID Nephrology. Urinary tract diseases NIH 3T3 Cells Other treatments Pharmacology. Drug treatments Prostatic Neoplasms - genetics Prostatic Neoplasms - immunology Prostatic Neoplasms - pathology Prostatic Neoplasms - therapy Receptors, Antigen, T-Cell - genetics Receptors, Antigen, T-Cell - immunology T-Lymphocytes - immunology Transduction, Genetic Treatment. General aspects Tumors Tumors of the urinary system Urinary tract. Prostate gland
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